Critical determinants of metastasis.


:The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second, the process of metastasis selects for a small subpopulation of cells that preexist within a parental neoplasm. Third, and perhaps the greatest obstacle for therapy, is that the outcome of metastasis depends on multiple interactions ('cross-talk') of metastatic cells with homeostatic mechanisms which the tumor cells usurp. Most recent data demonstrate that the organ microenvironment can influence the growth, invasion, and response of metastases to chemotherapy. Therapy of metastasis should therefore be targeted against both the metastatic tumor cells and the homeostatic factors that promote metastasis.


Semin Cancer Biol


Fidler IJ





Has Abstract


2002-04-01 00:00:00














  • LIM domain proteins in leukaemia and development.

    abstract::T cell acute leukaemias involve a number of different classes of oncogenes. A group of such genes is the RBTN family located on chromosomes 11 and 12. Two members of this family, RBTN1/Ttg-1 and RBTN2/Ttg-2, are located near recurring T cell acute lymphocytic leukaemia-associated translocations. Chromosomal translocat...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Sánchez-García I,Rabbitts TH

    更新日期:1993-12-01 00:00:00

  • The genetic analysis of prostate carcinoma.

    abstract::The molecular events underlying prostatic tumorigenesis remain incompletely understood. The application of cytogenetic, molecular genetic and molecular cytogenetic techniques have led to the identification of consistent genetic changes. This paper will discuss these techniques, review the genetic aberrations discovere...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Roylance R,Spurr N,Sheer D

    更新日期:1997-02-01 00:00:00

  • Emergence and prevention of resistance against small molecule inhibitors.

    abstract::Small molecule inhibitors target specific metabolic pathways in tumor cells and are a promising class of drugs for the treatment of cancers. The best known example is the treatment of chronic myeloid leukemia (CML) with Gleevec. This is a small molecule inhibitor of the Bcr-Abl kinase which has been shown to drive the...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Wodarz D,Komarova NL

    更新日期:2005-12-01 00:00:00

  • Tumor metabolism as modulator of immune response and tumor progression.

    abstract::About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of cancer cell. In the meantime it has become clear, that the altered glucose metabolism is only one piece of the tumor metabolome puzzle....

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Gottfried E,Kreutz M,Mackensen A

    更新日期:2012-08-01 00:00:00

  • Evolving paradigms in multifocal breast cancer.

    abstract::The 7th edition of the TNM defines multifocal breast cancer as multiple simultaneous ipsilateral and synchronous breast cancer lesions, provided they are macroscopically distinct and measurable using current traditional pathological and clinical tools. According to the College of American Pathologists (CAP), the chara...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Salgado R,Aftimos P,Sotiriou C,Desmedt C

    更新日期:2015-04-01 00:00:00

  • The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.

    abstract::Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation a...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Huynh J,Etemadi N,Hollande F,Ernst M,Buchert M

    更新日期:2017-08-01 00:00:00

  • Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy.

    abstract::Angiogenesis, the growth of blood capillaries, is regulated by soluble growth factors and insoluble extracellular matrix (ECM) molecules. Soluble angiogenic mitogens act over large distances to initiate capillary growth whereas changes in ECM govern whether individual cells will grow, differentiate, or involute in res...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Ingber DE

    更新日期:1992-04-01 00:00:00

  • Cell-intrinsic survival signals. The role of autophagy in metastatic dissemination and tumor cell dormancy.

    abstract::Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Vera-Ramirez L

    更新日期:2020-02-01 00:00:00

  • NF-κB deregulation in splenic marginal zone lymphoma.

    abstract::Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Spina V,Rossi D

    更新日期:2016-08-01 00:00:00

  • The role of exosomes in cancer metastasis.

    abstract::Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes in...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Steinbichler TB,Dudás J,Riechelmann H,Skvortsova II

    更新日期:2017-06-01 00:00:00

  • Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer.

    abstract::Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion. It has recently been confirmed as a significant promoter of malignant progression. Its role in signal transduction was first implied through the interaction with inte...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Kos J,Vižin T,Fonović UP,Pišlar A

    更新日期:2015-04-01 00:00:00

  • From autophagic to necrotic cell death in Dictyostelium.

    abstract::Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Tresse E,Kosta A,Luciani MF,Golstein P

    更新日期:2007-04-01 00:00:00

  • Tumour escape from immune surveillance through dendritic cell inactivation.

    abstract::Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Vicari AP,Caux C,Trinchieri G

    更新日期:2002-02-01 00:00:00

  • Bioblockades join the assault on small G protein signalling.

    abstract::Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Mott HR,Owen D

    更新日期:2019-02-01 00:00:00

  • The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition.

    abstract::The marginal level of clinical responses to the Chloroethylnitrosoureas (CENU, i.e. BCNU, CCNU, MeCCNU) suggests that there may exist an innate mechanism of resistance in tumors to these chemotherapeutic agents. A decade of research from many laboratories around the world has led to the identification of the mechanism...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Erickson LC

    更新日期:1991-08-01 00:00:00

  • Laminin isoforms in tumor invasion, angiogenesis and metastasis.

    abstract::Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Patarroyo M,Tryggvason K,Virtanen I

    更新日期:2002-06-01 00:00:00

  • B-cell receptor signaling as a driver of lymphoma development and evolution.

    abstract::The B-cell receptor (BCR) is essential for normal B-cell development and maturation. In an increasing number of B-cell malignancies, BCR signaling is implicated as a pivotal pathway in tumorigenesis. Mechanisms of BCR activation are quite diverse and range from chronic antigenic drive by microbial or viral antigens to...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Niemann CU,Wiestner A

    更新日期:2013-12-01 00:00:00

  • Spatial genome organization in the formation of chromosomal translocations.

    abstract::Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Meaburn KJ,Misteli T,Soutoglou E

    更新日期:2007-02-01 00:00:00

  • Multistep skin cancer in mice as a model to study the evolution of cancer cells.

    abstract::Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Kemp CJ

    更新日期:2005-12-01 00:00:00

  • Bacterial infection increases risk of carcinogenesis by targeting mitochondria.

    abstract::As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compar...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Strickertsson JAB,Desler C,Rasmussen LJ

    更新日期:2017-12-01 00:00:00

  • Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment.

    abstract::The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Yang H,Chen X,Li K,Cheaito H,Yang Q,Wu G,Liu J,Dou QP

    更新日期:2019-12-26 00:00:00

  • Enzymes involved in tumor-driven angiogenesis: A valuable target for anticancer therapy.

    abstract::Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro M

    更新日期:2019-06-01 00:00:00

  • Genetic drivers of NF-κB deregulation in diffuse large B-cell lymphoma.

    abstract::Diffuse large B cell lymphoma (DLBCL) is the most common form of B cell non-Hodgkin lymphoma worldwide and comprises a heterogeneous group of malignancies that originate from the malignant transformation of germinal center (GC) B cells. Over the past decade, significant improvement has been achieved in our understandi...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Pasqualucci L,Zhang B

    更新日期:2016-08-01 00:00:00

  • Microenvironment and HIV-related lymphomagenesis.

    abstract::Patients with HIV infection are at increased risk of developing non-Hodgkin lymphoma and Hodgkin lymphoma. While the pathogenesis of these lymphomas is incompletely understood, evidence indicates that immune deregulation, genetic alterations and cytokine production play an important role in HIV lymphomagenesis. The ly...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Pantanowitz L,Carbone A,Dolcetti R

    更新日期:2015-10-01 00:00:00

  • Novel therapeutic interventions in cancer treatment using protein and peptide-based targeted smart systems.

    abstract::Cancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient- and tumor-specific marker...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Zafar S,Beg S,Panda SK,Rahman M,Alharbi KS,Jain GK,Ahmad FJ

    更新日期:2019-08-20 00:00:00

  • Nutrigenomics in cancer: Revisiting the effects of natural compounds.

    abstract::Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

    更新日期:2017-10-01 00:00:00

  • Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies.

    abstract::Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (ove...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Mantso T,Goussetis G,Franco R,Botaitis S,Pappa A,Panayiotidis M

    更新日期:2016-06-01 00:00:00

  • Familial nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Zeng YX,Jia WH

    更新日期:2002-12-01 00:00:00

  • Growing evidence that several human cancers may originate in utero.

    abstract::Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Ekbom A

    更新日期:1998-08-01 00:00:00

  • T antigen transgenic mouse models.

    abstract::The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审


    authors: Sáenz Robles MT,Pipas JM

    更新日期:2009-08-01 00:00:00