Abstract:
:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusion protein with N-terminal gag and other viral sequences. The cellular homologue of v-ski, c-ski, is a large gene comprising at least 70 kb and containing at least seven coding exons. V-ski consists of most of the first five coding exons of c-ski. The proteins encoded by both genes are nuclear proteins that bind DNA and contain recognised motifs common to known nuclear regulatory proteins. A c-ski-related gene called sno has also been recently identified and, like c-ski, it is expressed in several human tumour cell lines.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Colmenares C,Stavnezer Esubject
Has Abstractpub_date
1990-12-01 00:00:00pages
383-7issue
6eissn
1044-579Xissn
1096-3650journal_volume
1pub_type
杂志文章,评审abstract::The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechan...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2020.08.009
更新日期:2020-08-25 00:00:00
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2013.12.009
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2012.03.005
更新日期:2012-06-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.06.011
更新日期:2017-10-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.11.003
更新日期:2020-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2009.02.002
更新日期:2009-08-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1993-06-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.09.001
更新日期:2020-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.02.006
更新日期:2017-06-01 00:00:00
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journal_title:Seminars in cancer biology
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doi:10.1016/j.semcancer.2020.03.001
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1997.0051
更新日期:1997-02-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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更新日期:1994-06-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.08.001
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abstract::Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.01.001
更新日期:2019-02-01 00:00:00
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journal_title:Seminars in cancer biology
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更新日期:2019-06-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/S1044-579X(02)00023-8
更新日期:2002-06-01 00:00:00
abstract::The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1994-02-01 00:00:00