The genetic analysis of prostate carcinoma.

abstract：:Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

journal_title：Seminars in cancer biology

authors： Kittler R,Buchholz F

更新日期：2003-08-01 00:00:00

abstract：:Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

journal_title：Seminars in cancer biology

authors： Mucke HAM

更新日期：2019-09-20 00:00:00

abstract：:The B-cell receptor (BCR) is essential for normal B-cell development and maturation. In an increasing number of B-cell malignancies, BCR signaling is implicated as a pivotal pathway in tumorigenesis. Mechanisms of BCR activation are quite diverse and range from chronic antigenic drive by microbial or viral antigens to...

journal_title：Seminars in cancer biology

authors： Niemann CU,Wiestner A

更新日期：2013-12-01 00:00:00

abstract：:The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

journal_title：Seminars in cancer biology

authors： Wang H,Maitra A,Wang H

更新日期：2016-02-01 00:00:00

abstract：:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ...

journal_title：Seminars in cancer biology

authors： Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus A

更新日期：2000-02-01 00:00:00

abstract：:In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understandi...

journal_title：Seminars in cancer biology

authors： van Leeuwen F,Nusse R

更新日期：1995-06-01 00:00:00

abstract：:Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (ove...

journal_title：Seminars in cancer biology

authors： Mantso T,Goussetis G,Franco R,Botaitis S,Pappa A,Panayiotidis M

更新日期：2016-06-01 00:00:00

abstract：:While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...

journal_title：Seminars in cancer biology

authors： Dumas JF,Brisson L,Chevalier S,Mahéo K,Fromont G,Moussata D,Besson P,Roger S

更新日期：2017-04-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads ...

journal_title：Seminars in cancer biology

authors： Lossos IS,Levy R

更新日期：2003-06-01 00:00:00

abstract：:T cell acute leukaemias involve a number of different classes of oncogenes. A group of such genes is the RBTN family located on chromosomes 11 and 12. Two members of this family, RBTN1/Ttg-1 and RBTN2/Ttg-2, are located near recurring T cell acute lymphocytic leukaemia-associated translocations. Chromosomal translocat...

journal_title：Seminars in cancer biology

authors： Sánchez-García I,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the adv...

journal_title：Seminars in cancer biology

authors： Afzal M,Ameeduzzafar,Alharbi KS,Alruwaili NK,Al-Abassi FA,Al-Malki AAL,Kazmi I,Kumar V,Kamal MA,Nadeem MS,Aslam M,Anwar F

更新日期：2019-12-20 00:00:00

abstract：:The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

journal_title：Seminars in cancer biology

authors： Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

更新日期：2020-12-02 00:00:00

abstract：:Managing cancer is now one of the biggest concerns of health organizations. Many strategies have been developed in drug discovery pipelines to help rectify this problem and two of the best ones are drug repurposing and computational methods. The combination of these approaches can have immense impact on the course of ...

journal_title：Seminars in cancer biology

authors： Sohraby F,Aryapour H

更新日期：2020-04-28 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...

journal_title：Seminars in cancer biology

authors： Patarroyo M,Tryggvason K,Virtanen I

更新日期：2002-06-01 00:00:00

abstract：:Angiogenesis, the growth of blood capillaries, is regulated by soluble growth factors and insoluble extracellular matrix (ECM) molecules. Soluble angiogenic mitogens act over large distances to initiate capillary growth whereas changes in ECM govern whether individual cells will grow, differentiate, or involute in res...

journal_title：Seminars in cancer biology

authors： Ingber DE

更新日期：1992-04-01 00:00:00

abstract：:In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

journal_title：Seminars in cancer biology

authors： Tsai CJ,Nussinov R

更新日期：2013-08-01 00:00:00

abstract：:The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studie...

journal_title：Seminars in cancer biology

authors： de Vries A,van Steeg H

更新日期：1996-10-01 00:00:00

abstract：:Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestig...

journal_title：Seminars in cancer biology

authors： Kim HJ,Maiti P,Barrientos A

更新日期：2017-12-01 00:00:00

abstract：:Patients with HIV infection are at increased risk of developing non-Hodgkin lymphoma and Hodgkin lymphoma. While the pathogenesis of these lymphomas is incompletely understood, evidence indicates that immune deregulation, genetic alterations and cytokine production play an important role in HIV lymphomagenesis. The ly...

journal_title：Seminars in cancer biology

authors： Pantanowitz L,Carbone A,Dolcetti R

更新日期：2015-10-01 00:00:00

abstract：:Malignant mesothelioma, a tumor of the pleura, pericardium, and peritoneum, is presently a worldwide problem. Current therapy is ineffective in slowing the course of the disease, and median survival from the time of diagnosis is rarely greater than 1 year. While the tumor was almost unknown prior to the second half of...

journal_title：Seminars in cancer biology

authors： Rizzo P,Bocchetta M,Powers A,Foddis R,Stekala E,Pass HI,Carbone M

更新日期：2001-02-01 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an...

journal_title：Seminars in cancer biology

authors： Hayward GS

更新日期：1999-06-01 00:00:00

abstract：:Over the last decade, the development and progress of next-generation sequencers incorporated with classical biochemical analyses have drastically produced novel insights into transcription factors, including Sry-like high-mobility group box (SOX) factors. In addition to their primary functions in binding to and activ...

journal_title：Seminars in cancer biology

authors： Higashijima Y,Kanki Y

更新日期：2020-12-01 00:00:00

abstract：:Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current...

journal_title：Seminars in cancer biology

authors： Wu L,Griffin JD

更新日期：2004-10-01 00:00:00

abstract：:Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regul...

journal_title：Seminars in cancer biology

authors： Sukocheva OA,Lukina E,Friedemann M,Menschikowski M,Hagelgans A,Aliev G

更新日期：2020-12-07 00:00:00

abstract：:The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in diverse biological effects, such as cell cycle arrest, apoptosis, senescence, differentiation...

journal_title：Seminars in cancer biology

authors： el-Deiry WS

更新日期：1998-01-01 00:00:00

abstract：:Ubiquitination plays a key role in regulating the tumour suppressor p53. It targets p53 for degradation by the 26S proteasome. The ubiquitin pathway also regulates the activity and localisation of p53. Ubiquitination requires ubiquitin-activating and -conjugating enzymes and ubiquitin ligases. In addition, ubiquitinat...

journal_title：Seminars in cancer biology

authors： Allende-Vega N,Saville MK

更新日期：2010-02-01 00:00:00

abstract：:Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...

journal_title：Seminars in cancer biology

authors： Johansson MH,Höglund P

更新日期：2006-10-01 00:00:00