Abstract：
:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ovalbumin-immunized mice. Our results demonstrate that HDC is inducible in Jurkat cells by anti-CD3. The H1 receptor antagonist triprolidine dose dependently inhibits proliferation of both Jurkat cells and ovalbumin-stimulated murine lymphocytes, while the H2 antagonist ranitidine was ineffective. Alpha-fluoro-methyl-histidine blocking HDC activity did not inhibit the T cell proliferation, suggesting an existing pool of histamine in T cells.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus Adoi
10.1006/scbi.2000.0306keywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
41-5issue
1eissn
1044-579Xissn
1096-3650pii
S1044579X00903067journal_volume
10pub_type
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journal_title：Seminars in cancer biology
pub_type： 杂志文章,评审
doi：
更新日期：1991-04-01 00:00:00
