Novel functions of interferon-induced proteins.

abstract：:Genital human papillomavirus (HPV) infections are the viral sexually transmitted diseases most frequently diagnosed that include anogenital condylomas and squamous intra-$bepithelial lesions, among which the precursors of invasive carcinomas of the uterine cervix. In animal PV models, vaccination against L1 and/or L2 ...

journal_title：Seminars in cancer biology

authors： Breitburd F,Coursaget P

更新日期：1999-12-01 00:00:00

abstract：:Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

journal_title：Seminars in cancer biology

authors： Lehembre F,Regenass U

更新日期：2012-06-01 00:00:00

abstract：:What is the clinical significance of the expression by common human carcinomas of the Thomsen-Friedenreich (TF) antigen? Described as a terminal disaccharide which is a precursor of MN blood group antigens, it was discovered as a laboratory curiosity 60 years ago, yet its cancer-association has only been appreciated i...

journal_title：Seminars in cancer biology

authors： MacLean GD,Longenecker BM

更新日期：1991-12-01 00:00:00

abstract：:Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the qualit...

journal_title：Seminars in cancer biology

authors： Andrijauskaite K,Wargovich MJ

更新日期：2020-09-03 00:00:00

abstract：:Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...

journal_title：Seminars in cancer biology

authors： Meaburn KJ,Misteli T,Soutoglou E

更新日期：2007-02-01 00:00:00

abstract：:The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studie...

journal_title：Seminars in cancer biology

authors： de Vries A,van Steeg H

更新日期：1996-10-01 00:00:00

abstract：:The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

journal_title：Seminars in cancer biology

authors： Ponzio NM,Thorbecke GJ

更新日期：2000-10-01 00:00:00

abstract：:Clinical Oncologists have largely ignored the debate over genetic instability in human cancers. It is clear that genetic lesions themselves provide valuable information in the treatment of patients with cancer and those genetic lesions can be exploited successfully as therapeutic targets. Whether the mechanisms result...

journal_title：Seminars in cancer biology

authors： Diaz LA Jr

更新日期：2005-02-01 00:00:00

abstract：:The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

journal_title：Seminars in cancer biology

authors： Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

更新日期：2020-12-02 00:00:00

abstract：:While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematological malignancies...

journal_title：Seminars in cancer biology

authors： Perez DR,Sklar LA,Chigaev A,Matlawska-Wasowska K

更新日期：2020-02-07 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environ...

journal_title：Seminars in cancer biology

authors： Bustamante P,Piquet L,Landreville S,Burnier JV

更新日期：2020-05-22 00:00:00

abstract：:Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made o...

journal_title：Seminars in cancer biology

authors： Burns J,Wilding CP,L Jones R,H Huang P

更新日期：2020-04-01 00:00:00

abstract：:Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...

journal_title：Seminars in cancer biology

authors： Stetler-Stevenson WG,Hewitt R,Corcoran M

更新日期：1996-06-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...

journal_title：Seminars in cancer biology

authors： Münz C,Nickolaus P,Lammert E,Pascolo S,Stevanović S,Rammensee HG

更新日期：1999-02-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The former is a branch of the glucose metabolic pathway that provides donor molecules for glycosylation processes, whereas the second requires co-translational N-glycosylation...

journal_title：Seminars in cancer biology

authors： Vasseur S,Manié SN

更新日期：2015-08-01 00:00:00

abstract：:Amino-bisphosphonates (N-BPs) have been commercially available for over four decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of malignancy, and bone metastases derived from various cancer types. Zoledronate and alendronate, two of the most potent N-BPs, have demonstrated direct t...

journal_title：Seminars in cancer biology

authors： La-Beck NM,Liu X,Shmeeda H,Shudde C,Gabizon AA

更新日期：2019-12-23 00:00:00

abstract：:Growing evidence supports the notion that pharmaceutical targeting of the 5-hydroxytryptamine (5-HT) and dopamine (DA) systems offers the potential to treat human immune system disorders. This review describes this emerging area of research, which has the benefit of being supported by a relatively detailed understandi...

journal_title：Seminars in cancer biology

authors： Barnes NM,Gordon J

更新日期：2008-06-01 00:00:00

abstract：:Primary liver cancer is the second most common malignancy, and currently results in 360,000 incident cases, and 350,000 deaths a year in China. For the past four decades, three national surveys on cancer mortality during the periods of 1973-1975, 1990-1992, and 2004-2005 have made it possible to estimate China's past ...

journal_title：Seminars in cancer biology

authors： Chen JG,Zhang SW

更新日期：2011-02-01 00:00:00

abstract：:Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, ...

journal_title：Seminars in cancer biology

authors： Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro M

更新日期：2019-06-01 00:00:00

abstract：:Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context o...

journal_title：Seminars in cancer biology

authors： Maley CC,Reid BJ

更新日期：2005-12-01 00:00:00

abstract：:The molecular events underlying prostatic tumorigenesis remain incompletely understood. The application of cytogenetic, molecular genetic and molecular cytogenetic techniques have led to the identification of consistent genetic changes. This paper will discuss these techniques, review the genetic aberrations discovere...

journal_title：Seminars in cancer biology

authors： Roylance R,Spurr N,Sheer D

更新日期：1997-02-01 00:00:00

abstract：:Alterations in the rate and pattern of cell movement are prominent features of many human diseases, including inflammation, cardiovascular disease and cancer. The ability to regulate the interactions of cells with each other and with adhesion factors in extracellular matrices therefore offers a novel approach to the t...

journal_title：Seminars in cancer biology

authors： Humphries MJ

更新日期：1993-10-01 00:00:00

abstract：:Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

journal_title：Seminars in cancer biology

authors： Laconi E,Doratiotto S,Vineis P

更新日期：2008-10-01 00:00:00

abstract：:Investigations across a range of disciplines over the past decade have brought the study of cell motility and its role in invasion to an exciting threshold. The biophysical forces proximally involved in generating cell locomotion, as well as the underlying signaling and genomic regulatory processes, are gradually beco...

journal_title：Seminars in cancer biology

authors： Kassis J,Lauffenburger DA,Turner T,Wells A

更新日期：2001-04-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Mos...

journal_title：Seminars in cancer biology

authors： Khan P,Siddiqui JA,Maurya SK,Lakshmanan I,Jain M,Ganti AK,Salgia R,Batra SK,Nasser MW

更新日期：2020-11-18 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...

journal_title：Seminars in cancer biology

authors： Wang W,Kandimalla R,Huang H,Zhu L,Li Y,Gao F,Goel A,Wang X

更新日期：2019-04-01 00:00:00

abstract：:Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the r...

journal_title：Seminars in cancer biology

authors： Mantovani A,Allavena P,Sozzani S,Vecchi A,Locati M,Sica A

更新日期：2004-06-01 00:00:00