The current clinical value of genomic instability.

Abstract:

:Clinical Oncologists have largely ignored the debate over genetic instability in human cancers. It is clear that genetic lesions themselves provide valuable information in the treatment of patients with cancer and those genetic lesions can be exploited successfully as therapeutic targets. Whether the mechanisms resulting in the accumulation of genetic lesions can be translated and used clinically remains to be seen.

journal_name

Semin Cancer Biol

authors

Diaz LA Jr

doi

10.1016/j.semcancer.2004.09.009

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

67-71

issue

1

eissn

1044-579X

issn

1096-3650

pii

S1044-579X(04)00086-0

journal_volume

15

pub_type

杂志文章,评审
  • Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.

    abstract::In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understandi...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1995.0018

    authors: van Leeuwen F,Nusse R

    更新日期:1995-06-01 00:00:00

  • From autophagic to necrotic cell death in Dictyostelium.

    abstract::Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2006.10.010

    authors: Tresse E,Kosta A,Luciani MF,Golstein P

    更新日期:2007-04-01 00:00:00

  • The molecular basis of targeting protein kinases in cancer therapeutics.

    abstract::In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2013.04.001

    authors: Tsai CJ,Nussinov R

    更新日期:2013-08-01 00:00:00

  • Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7.

    abstract::Understanding the molecular and genetic determinants of cancer will provide unique opportunities for developing rational and effective therapies. Malignant cells are frequently resistant to chemotherapy and radiation induced programmed cell death (apoptosis). This resistance can occur by mutations in the tumor suppres...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1044-579x(02)00134-7

    authors: Lebedeva IV,Su ZZ,Sarkar D,Fisher PB

    更新日期:2003-04-01 00:00:00

  • Progress in treatment and risk stratification of neuroblastoma: impact on future clinical and basic research.

    abstract::Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2011.07.002

    authors: Øra I,Eggert A

    更新日期:2011-10-01 00:00:00

  • An update on vitamin D signaling and cancer.

    abstract::A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2020.05.018

    authors: Carlberg C,Muñoz A

    更新日期:2020-05-30 00:00:00

  • Targeting T cells for GVHD therapy.

    abstract::Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0009

    authors: Vallera DA

    更新日期:1996-04-01 00:00:00

  • Metastatic disease: a drug discovery perspective.

    abstract::Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2012.03.005

    authors: Lehembre F,Regenass U

    更新日期:2012-06-01 00:00:00

  • Mammary tumorigenesis and metastasis in transgenic mice.

    abstract::The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Webster MA,Muller WJ

    更新日期:1994-02-01 00:00:00

  • Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic.

    abstract::Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0020

    authors: Stetler-Stevenson WG,Hewitt R,Corcoran M

    更新日期:1996-06-01 00:00:00

  • Xpa knockout mice.

    abstract::The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studie...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0031

    authors: de Vries A,van Steeg H

    更新日期:1996-10-01 00:00:00

  • The retinoblastoma protein and its relatives.

    abstract::The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1995.0011

    authors: Whyte P

    更新日期:1995-04-01 00:00:00

  • Circular RNAs as biomarkers and therapeutic targets in cancer.

    abstract::Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.12.026

    authors: Beilerli A,Gareev I,Beylerli O,Yang G,Pavlov V,Aliev G,Ahmad A

    更新日期:2021-01-09 00:00:00

  • Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.

    abstract::Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the r...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2003.10.001

    authors: Mantovani A,Allavena P,Sozzani S,Vecchi A,Locati M,Sica A

    更新日期:2004-06-01 00:00:00

  • PIWI-interacting RNAs in human cancer.

    abstract::P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.08.012

    authors: Lin Y,Zheng J,Lin D

    更新日期:2020-09-01 00:00:00

  • Tumour escape from immune surveillance through dendritic cell inactivation.

    abstract::Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2001.0400

    authors: Vicari AP,Caux C,Trinchieri G

    更新日期:2002-02-01 00:00:00

  • Relationship of p53 to the control of apoptotic cell death.

    abstract::While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Oren M

    更新日期:1994-06-01 00:00:00

  • The genomic risk of somatic gene therapy.

    abstract::Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2010.06.003

    authors: Kustikova O,Brugman M,Baum C

    更新日期:2010-08-01 00:00:00

  • NF-κB deregulation in splenic marginal zone lymphoma.

    abstract::Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2016.08.002

    authors: Spina V,Rossi D

    更新日期:2016-08-01 00:00:00

  • The SRE: a growth factor responsive transcriptional regulator.

    abstract::Cellular immediate-early genes are rapidly and transiently activated when cells are stimulated with many different growth factors. This review examines the function of a short immediate-early gene regulatory sequence, the Serum Response Element (SRE), that is sufficient for this transient transcriptional activation. T...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Treisman R

    更新日期:1990-02-01 00:00:00

  • What patents tell us about drug repurposing for cancer: A landscape analysis.

    abstract::Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.09.010

    authors: Mucke HAM

    更新日期:2019-09-20 00:00:00

  • Immunotherapy of cancer using cytokine gene-modified tumor vaccines.

    abstract::Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Gilboa E,Lyerly HK,Vieweg J,Saito S

    更新日期:1994-12-01 00:00:00

  • Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

    abstract::DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2014.06.002

    authors: Skvortsov S,Debbage P,Lukas P,Skvortsova I

    更新日期:2015-04-01 00:00:00

  • Requirement for reverse immune surveillance for the growth of germinal center-derived murine lymphomas.

    abstract::The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2000.0330

    authors: Ponzio NM,Thorbecke GJ

    更新日期:2000-10-01 00:00:00

  • Spatial genome organization in the formation of chromosomal translocations.

    abstract::Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2006.10.008

    authors: Meaburn KJ,Misteli T,Soutoglou E

    更新日期:2007-02-01 00:00:00

  • Proteomic research in sarcomas - current status and future opportunities.

    abstract::Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made o...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.11.003

    authors: Burns J,Wilding CP,L Jones R,H Huang P

    更新日期:2020-04-01 00:00:00

  • Definition of tumor antigens suitable for vaccine construction.

    abstract::The treatment of cancer with tumor vaccines has been a goal of physicians and scientists ever since effective immunization against infectious disease with vaccines was developed. In the past, major tumor antigens had not been molecularly characterized. Recent advances are, however, beginning to define potential molecu...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/1044-579x(95)90001-2

    authors: Lewis JJ,Houghton AN

    更新日期:1995-12-01 00:00:00

  • Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment.

    abstract::Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics be...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2009.02.007

    authors: Dworkin AM,Huang TH,Toland AE

    更新日期:2009-06-01 00:00:00

  • ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

    abstract::Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The former is a branch of the glucose metabolic pathway that provides donor molecules for glycosylation processes, whereas the second requires co-translational N-glycosylation...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2015.04.001

    authors: Vasseur S,Manié SN

    更新日期:2015-08-01 00:00:00

  • Bacterial infection increases risk of carcinogenesis by targeting mitochondria.

    abstract::As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compar...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2017.07.003

    authors: Strickertsson JAB,Desler C,Rasmussen LJ

    更新日期:2017-12-01 00:00:00