Abstract:
:Angiogenesis plays a pivotal role in cancer progression and is required for tissue invasion and metastasis. Starting with Folkman's initial observations in 1971, basic research continued to shed new molecular insight into this multifaceted process, leading to the development of several anti-angiogenic drugs. To date, anti-vascular endothelial growth factor monoclonal antibodies, such as bevacizumab and ramucirumab, and receptor tyrosine kinase inhibitors (e.g., sorafenib, sunitinib, regorafenib and axitinib) have had a profound impact on the way we treat patients with advanced cancer, providing in some cases unprecedented clinical benefit. The molecular mechanisms underlying tumor-driven angiogenesis have been explored extensively and have unveiled a number of potential clinically relevant targets, including several novel enzymes. In this review, we summarized the current strategies to target tumor-driven angiogenesis through the inhibition of relevant and selected classes of enzymes involved in this process.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Ricciuti B,Foglietta J,Bianconi V,Sahebkar A,Pirro Mdoi
10.1016/j.semcancer.2017.11.005subject
Has Abstractpub_date
2019-06-01 00:00:00pages
87-99eissn
1044-579Xissn
1096-3650pii
S1044-579X(17)30043-3journal_volume
56pub_type
杂志文章,评审abstract::Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to onc...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2011.12.007
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 社论
doi:10.1016/j.semcancer.2006.11.001
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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doi:10.1016/j.semcancer.2020.04.007
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