Harnessing serotonergic and dopaminergic pathways for lymphoma therapy: evidence and aspirations.

abstract：:High-throughput molecular profiling of tumors is a fundamental aspect of precision oncology, enabling the identification of genomic alterations that can be targeted therapeutically. In this context, a patient is matched to a specific drug or therapy based on the tumor's underlying genetic driver events rather than the...

journal_title：Seminars in cancer biology

authors： Jäger N

更新日期：2021-01-18 00:00:00

abstract：:Inhibition of Ras signalling has been a goal almost since its central role in cell signalling and its deregulation in disease were discovered. Early attempts at inhibiting its post-translational modification using peptidomimetics were successful in cell culture but failed spectacularly in clinical trials, making indus...

journal_title：Seminars in cancer biology

authors： Mott HR,Owen D

更新日期：2019-02-01 00:00:00

abstract：:Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an...

journal_title：Seminars in cancer biology

authors： Hayward GS

更新日期：1999-06-01 00:00:00

abstract：:The development of vaccines for melanoma has been accelerated by the identification of melanoma-associated antigens, a better understanding of basic immunologic principles, and the ability to construct complex vectors for immunization. The location and context in which T-cell priming occurs significantly influences th...

journal_title：Seminars in cancer biology

authors： Hörig H,Kaufman HL

更新日期：2003-12-01 00:00:00

abstract：:In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understandi...

journal_title：Seminars in cancer biology

authors： van Leeuwen F,Nusse R

更新日期：1995-06-01 00:00:00

abstract：:Angiogenesis, the growth of blood capillaries, is regulated by soluble growth factors and insoluble extracellular matrix (ECM) molecules. Soluble angiogenic mitogens act over large distances to initiate capillary growth whereas changes in ECM govern whether individual cells will grow, differentiate, or involute in res...

journal_title：Seminars in cancer biology

authors： Ingber DE

更新日期：1992-04-01 00:00:00

abstract：:Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics be...

journal_title：Seminars in cancer biology

authors： Dworkin AM,Huang TH,Toland AE

更新日期：2009-06-01 00:00:00

abstract：:The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in diverse biological effects, such as cell cycle arrest, apoptosis, senescence, differentiation...

journal_title：Seminars in cancer biology

authors： el-Deiry WS

更新日期：1998-01-01 00:00:00

abstract：:Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...

journal_title：Seminars in cancer biology

authors： Stetler-Stevenson WG,Hewitt R,Corcoran M

更新日期：1996-06-01 00:00:00

abstract：:Clinical Oncologists have largely ignored the debate over genetic instability in human cancers. It is clear that genetic lesions themselves provide valuable information in the treatment of patients with cancer and those genetic lesions can be exploited successfully as therapeutic targets. Whether the mechanisms result...

journal_title：Seminars in cancer biology

authors： Diaz LA Jr

更新日期：2005-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of development of CRC is complex and multifactorial, and includes disruption of homeostasis of the intestinal epithelial layer mediated though dysregulations of tumor suppressing/promoting signaling pathways. Guanylate cyclase 2C (...

journal_title：Seminars in cancer biology

authors： Yarla NS,Gali H,Pathuri G,Smriti S,Farooqui M,Panneerselvam J,Kumar G,Madka V,Rao CV

更新日期：2019-06-01 00:00:00

abstract：:About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of cancer cell. In the meantime it has become clear, that the altered glucose metabolism is only one piece of the tumor metabolome puzzle....

journal_title：Seminars in cancer biology

authors： Gottfried E,Kreutz M,Mackensen A

更新日期：2012-08-01 00:00:00

abstract：:Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer ri...

journal_title：Seminars in cancer biology

authors： Reznikoff CA,Kao C,Messing EM,Newton M,Swaminathan S

更新日期：1993-06-01 00:00:00

abstract：:Malignant mesothelioma, a tumor of the pleura, pericardium, and peritoneum, is presently a worldwide problem. Current therapy is ineffective in slowing the course of the disease, and median survival from the time of diagnosis is rarely greater than 1 year. While the tumor was almost unknown prior to the second half of...

journal_title：Seminars in cancer biology

authors： Rizzo P,Bocchetta M,Powers A,Foddis R,Stekala E,Pass HI,Carbone M

更新日期：2001-02-01 00:00:00

abstract：:The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence o...

journal_title：Seminars in cancer biology

authors： Game JC

更新日期：1993-04-01 00:00:00

abstract：:The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of...

journal_title：Seminars in cancer biology

authors： Verhoeven Y,Tilborghs S,Jacobs J,De Waele J,Quatannens D,Deben C,Prenen H,Pauwels P,Trinh XB,Wouters A,Smits ELJ,Lardon F,van Dam PA

更新日期：2020-02-01 00:00:00

abstract：:The treatment of cancer with tumor vaccines has been a goal of physicians and scientists ever since effective immunization against infectious disease with vaccines was developed. In the past, major tumor antigens had not been molecularly characterized. Recent advances are, however, beginning to define potential molecu...

journal_title：Seminars in cancer biology

authors： Lewis JJ,Houghton AN

更新日期：1995-12-01 00:00:00

abstract：:Despite continuous improvements in cancer management, locoregional recurrence or metastatic spread still occurs in a high proportion of patients after radiotherapy or combined treatments. One underlying reason might be a low efficacy of current treatments on eradication of cancer stem cells (CSCs). It has been recogni...

journal_title：Seminars in cancer biology

authors： Koch U,Krause M,Baumann M

更新日期：2010-04-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:Cancer depends on cell death. It can emerge when cell death is deficient, and it could be treated through cancer-cell-specific induction of cell death. However, our understanding of cell death is still incomplete. While a few classical animal models have helped greatly in this respect, more may be learnt from non-clas...

journal_title：Seminars in cancer biology

authors： Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...

journal_title：Seminars in cancer biology

authors： Patarroyo M,Tryggvason K,Virtanen I

更新日期：2002-06-01 00:00:00

abstract：:The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

journal_title：Seminars in cancer biology

authors： Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

更新日期：2020-12-02 00:00:00

abstract：:While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...

journal_title：Seminars in cancer biology

authors： Dumas JF,Brisson L,Chevalier S,Mahéo K,Fromont G,Moussata D,Besson P,Roger S

更新日期：2017-04-01 00:00:00

abstract：:Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...

journal_title：Seminars in cancer biology

authors： Craig RW

更新日期：1995-02-01 00:00:00

abstract：:Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. A positive family history of breast cancer is one of the strongest risk factors for the disease. In addition, many afflicted breast cancer families are characterized by early onset and bilateral tumors, and also, in som...

journal_title：Seminars in cancer biology

authors： Arver B,Du Q,Chen J,Luo L,Lindblom A

更新日期：2000-08-01 00:00:00

abstract：:In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clini...

journal_title：Seminars in cancer biology

authors： Macerola E,Poma AM,Basolo F

更新日期：2020-10-19 00:00:00

abstract：:The need for more effective cancer therapies is omnipresent as the ever-complex, and highly adaptive, mechanisms of tumor biology allow this disease to elude even the most stringent treatment options. The expanding field of proteoglycan signaling is enticing as a reservoir of potential drug targets and prospects for n...

journal_title：Seminars in cancer biology

authors： Gubbiotti MA,Buraschi S,Kapoor A,Iozzo RV

更新日期：2020-05-01 00:00:00

abstract：:Different types of RNAs identified thus far represent a diverse group of macromolecules that are involved in the regulation of different biological processes. RNA is generally thought to be localized primarily in the nucleus and cytoplasm; however, some types of RNA have been detected in the extracellular milieu. Thes...

journal_title：Seminars in cancer biology

authors： Redzic JS,Balaj L,van der Vos KE,Breakefield XO

更新日期：2014-10-01 00:00:00

abstract：:P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

journal_title：Seminars in cancer biology

authors： Lin Y,Zheng J,Lin D

更新日期：2020-09-01 00:00:00

abstract：:Interferons are important cytokines which regulate antiviral, cell growth, immune modulatory and anti-tumor functions. These pleiotropic effects of interferons are brought about by a large number of cellular proteins, the interferon-inducible proteins. Investigation of the biochemical and cellular activities of some o...

journal_title：Seminars in cancer biology

authors： Sen GC

更新日期：2000-04-01 00:00:00