Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors.

abstract：:The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity. Similarly, in some types of can...

journal_title：Seminars in cancer biology

authors： Engelberg D

更新日期：2004-08-01 00:00:00

abstract：:Interferons are important cytokines which regulate antiviral, cell growth, immune modulatory and anti-tumor functions. These pleiotropic effects of interferons are brought about by a large number of cellular proteins, the interferon-inducible proteins. Investigation of the biochemical and cellular activities of some o...

journal_title：Seminars in cancer biology

authors： Sen GC

更新日期：2000-04-01 00:00:00

abstract：:Cancer metastasis is the leading cause of mortality in patients with solid tumors. The majority of these deaths are associated with metastatic disease that occurs after a period of clinical remission, anywhere from months to decades following removal of the primary mass. This dormancy is prominent in cancers of the br...

journal_title：Seminars in cancer biology

authors： Ma B,Wells A,Clark AM

更新日期：2020-02-01 00:00:00

abstract：:Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

journal_title：Seminars in cancer biology

authors： Ammanathan V,Vats S,Abraham IM,Manjithaya R

更新日期：2020-11-01 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:The molecular events underlying prostatic tumorigenesis remain incompletely understood. The application of cytogenetic, molecular genetic and molecular cytogenetic techniques have led to the identification of consistent genetic changes. This paper will discuss these techniques, review the genetic aberrations discovere...

journal_title：Seminars in cancer biology

authors： Roylance R,Spurr N,Sheer D

更新日期：1997-02-01 00:00:00

abstract：:A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

journal_title：Seminars in cancer biology

authors： Carlberg C,Muñoz A

更新日期：2020-05-30 00:00:00

abstract：:The 7th edition of the TNM defines multifocal breast cancer as multiple simultaneous ipsilateral and synchronous breast cancer lesions, provided they are macroscopically distinct and measurable using current traditional pathological and clinical tools. According to the College of American Pathologists (CAP), the chara...

journal_title：Seminars in cancer biology

authors： Salgado R,Aftimos P,Sotiriou C,Desmedt C

更新日期：2015-04-01 00:00:00

abstract：:Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biologica...

journal_title：Seminars in cancer biology

authors： Spina V,Rossi D

更新日期：2016-08-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:Data accumulating during the last two decades suggest that tumorigenesis is held in check by two major intrinsic failsafe mechanisms; apoptosis and cellular senescence. While apoptosis is a programmed cell death process, cellular senescence, which is the focus of this article, is defined as irreversible cell cycle arr...

journal_title：Seminars in cancer biology

authors： Larsson LG

更新日期：2011-12-01 00:00:00

abstract：:Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against ch...

journal_title：Seminars in cancer biology

authors： Espinoza-Sánchez NA,Götte M

更新日期：2020-05-01 00:00:00

abstract：:Human bladder carcinogenesis stands as a paradigm for research on the molecular genetic mechanisms of chemical carcinogenesis. The pathogenesis of bladder cancer is multistage with a typical onset later in life. Epidemiological studies associate occupational exposure to aromatic amines with increased bladder cancer ri...

journal_title：Seminars in cancer biology

authors： Reznikoff CA,Kao C,Messing EM,Newton M,Swaminathan S

更新日期：1993-06-01 00:00:00

abstract：:In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clini...

journal_title：Seminars in cancer biology

authors： Macerola E,Poma AM,Basolo F

更新日期：2020-10-19 00:00:00

abstract：:The development of vaccines for melanoma has been accelerated by the identification of melanoma-associated antigens, a better understanding of basic immunologic principles, and the ability to construct complex vectors for immunization. The location and context in which T-cell priming occurs significantly influences th...

journal_title：Seminars in cancer biology

authors： Hörig H,Kaufman HL

更新日期：2003-12-01 00:00:00

abstract：:Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically ...

journal_title：Seminars in cancer biology

authors： Brandau S,Moses K,Lang S

更新日期：2013-06-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and...

journal_title：Seminars in cancer biology

authors： Gabriely G,Quintana FJ

更新日期：2020-08-01 00:00:00

abstract：:Liver cancer is the fifth most common cancer and the third most common cause of cancer related death in the world. The recent development of new techniques for the investigations of global change in the gene expression, signaling pathways and wide genome binding has provided novel information for the mechanisms underl...

journal_title：Seminars in cancer biology

authors： Iakova P,Timchenko L,Timchenko NA

更新日期：2011-02-01 00:00:00

abstract：:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ...

journal_title：Seminars in cancer biology

authors： Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus A

更新日期：2000-02-01 00:00:00

abstract：:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins...

journal_title：Seminars in cancer biology

authors： Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui H

更新日期：2019-08-01 00:00:00

abstract：:Colorectal cancer is highly incident worldwide and presents a health burden with elevated mortality rate despite prevention, detection, and treatment, mainly due to metastatic liver disease. Histological growth patterns of colorectal cancer liver metastases have emerged as a reproducible prognostic factor, with biolog...

journal_title：Seminars in cancer biology

authors： Oliveira RC,Alexandrino H,Cipriano MA,Alves FC,Tralhão JG

更新日期：2020-07-14 00:00:00

abstract：:Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

journal_title：Seminars in cancer biology

authors： Chai AWY,Lim KP,Cheong SC

更新日期：2020-04-01 00:00:00

abstract：:The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence o...

journal_title：Seminars in cancer biology

authors： Game JC

更新日期：1993-04-01 00:00:00

abstract：:Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...

journal_title：Seminars in cancer biology

authors： Craig RW

更新日期：1995-02-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...

journal_title：Seminars in cancer biology

authors： Niedobitek G,Agathanggelou A,Nicholls JM

更新日期：1996-08-01 00:00:00

abstract：:Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...

journal_title：Seminars in cancer biology

authors： Kemp CJ

更新日期：2005-12-01 00:00:00

abstract：:Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

journal_title：Seminars in cancer biology

authors： Tresse E,Kosta A,Luciani MF,Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Raf-1 belongs to a family of serine/threonine protein kinases which are highly conserved through evolution in multicellular organisms. Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane t...

journal_title：Seminars in cancer biology

authors： Magnuson NS,Beck T,Vahidi H,Hahn H,Smola U,Rapp UR

更新日期：1994-08-01 00:00:00

abstract：:The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...

journal_title：Seminars in cancer biology

authors： Packham G,Stevenson F

更新日期：2010-12-01 00:00:00

abstract：:Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors. Cellular "morphinergic" signaling is predominantly targeted to autocrine/paracrine regulatory processes and is reciprocally linked to stimulate...

journal_title：Seminars in cancer biology

authors： Stefano GB,Kream R

更新日期：2008-06-01 00:00:00