Abstract:
:Raf-1 belongs to a family of serine/threonine protein kinases which are highly conserved through evolution in multicellular organisms. Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane to changes in the expression of genes involved in the control of cell growth, differentiation and survival. Regulation of Raf-1 activity is complex and involves Ras, as well as several serine/threonine and tyrosine kinases. Through a series of phosphorylation events, extracellular signals are connected through the Raf-1/MAP kinase pathway to activity-regulation of several oncogene-class transcription factors via phosphorylation of specific serine residues. Under ordinary circumstances, the cascade involving Raf-1 eventually leads to changes in gene expression and protein synthesis. Upon constitutive activation of Raf-1 kinase, as a result of genetic changes, a variety of cell types acquire a transformed phenotype.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Magnuson NS,Beck T,Vahidi H,Hahn H,Smola U,Rapp URsubject
Has Abstractpub_date
1994-08-01 00:00:00pages
247-53issue
4eissn
1044-579Xissn
1096-3650journal_volume
5pub_type
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