From autophagic to necrotic cell death in Dictyostelium.

abstract：:Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is rather recent. High stability, abundance and evolutionary conservati...

journal_title：Seminars in cancer biology

authors： Beilerli A,Gareev I,Beylerli O,Yang G,Pavlov V,Aliev G,Ahmad A

更新日期：2021-01-09 00:00:00

abstract：:The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and rodent tumors. These increases in cathepsin B activity correspond in part...

journal_title：Seminars in cancer biology

authors： Sloane BF

更新日期：1990-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to onc...

journal_title：Seminars in cancer biology

authors： Takada K

更新日期：2012-04-01 00:00:00

abstract：:The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are reversible, have opened up new therapeutic pathways for treating various diseases, including cancer. This has led the research for a better understanding of the...

journal_title：Seminars in cancer biology

authors： Ansari I,Chaturvedi A,Chitkara D,Singh S

更新日期：2021-01-06 00:00:00

abstract：:The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...

journal_title：Seminars in cancer biology

authors： Webster MA,Muller WJ

更新日期：1994-02-01 00:00:00

abstract：:T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in a...

journal_title：Seminars in cancer biology

authors： Münz C

更新日期：2020-11-01 00:00:00

abstract：:Although chemokines and their receptors were initially identified as regulators of cell trafficking during inflammation and immune response, they have emerged as crucial players in all stages of tumor development, primary growth, migration, angiogenesis, and establishment as metastases in distant target organs. Neuroe...

journal_title：Seminars in cancer biology

authors： Gross N,Meier R

更新日期：2009-04-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

journal_title：Seminars in cancer biology

authors： Mucke HAM

更新日期：2019-09-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common histological form of primary liver cancer; the tumor cells having retained features of hepatocytic differentiation. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs complicate the evolution of an activ...

journal_title：Seminars in cancer biology

authors： Bréchot C,Gozuacik D,Murakami Y,Paterlini-Bréchot P

更新日期：2000-06-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:The processes of intraepithelial migration, intraluminal seeding, and field cancerization as models for initiation, spread, and recurrences of urothelial cell carcinoma (UCC) are reviewed in light of recent molecular investigations. The accumulated molecular data on synchronous and metachronous tumors indicate that th...

journal_title：Seminars in cancer biology

authors： Höglund M

更新日期：2007-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has m...

journal_title：Seminars in cancer biology

authors： Alaseem A,Alhazzani K,Dondapati P,Alobid S,Bishayee A,Rathinavelu A

更新日期：2019-06-01 00:00:00

abstract：:Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads ...

journal_title：Seminars in cancer biology

authors： Lossos IS,Levy R

更新日期：2003-06-01 00:00:00

abstract：:Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance of signals from activating and inhibitory receptors. While reactivity against tumor cells is beneficial, it is essential that NK cells do not attack normal tissue. The disti...

journal_title：Seminars in cancer biology

authors： Johansson MH,Höglund P

更新日期：2006-10-01 00:00:00

abstract：:In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

journal_title：Seminars in cancer biology

authors： Tsai CJ,Nussinov R

更新日期：2013-08-01 00:00:00

abstract：:Cancer depends on cell death. It can emerge when cell death is deficient, and it could be treated through cancer-cell-specific induction of cell death. However, our understanding of cell death is still incomplete. While a few classical animal models have helped greatly in this respect, more may be learnt from non-clas...

journal_title：Seminars in cancer biology

authors： Golstein P

更新日期：2007-04-01 00:00:00

abstract：:Prostate specific antigen (PSA) is serine protease produced at high concentrations by normal and malignant prostatic epithelium. It is mainly secreted into seminal fluid, where it digests the gel forming after ejaculation. Only minor amounts of PSA leak out into circulation from the normal prostate, but the release of...

journal_title：Seminars in cancer biology

authors： Stenman UH,Leinonen J,Zhang WM,Finne P

更新日期：1999-04-01 00:00:00

abstract：:Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the adv...

journal_title：Seminars in cancer biology

authors： Afzal M,Ameeduzzafar,Alharbi KS,Alruwaili NK,Al-Abassi FA,Al-Malki AAL,Kazmi I,Kumar V,Kamal MA,Nadeem MS,Aslam M,Anwar F

更新日期：2019-12-20 00:00:00

abstract：:Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions. It also exists in lower molecular weight forms t...

journal_title：Seminars in cancer biology

authors： Stern R

更新日期：2008-08-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) is the most common form of lymphoid malignancy in Western countries, accounting for around a quarter of all leukaemias. Evidence from epidemiological and family studies have provided evidence for familial clustering of CLL compatible with inherited genetic predisposition to CLL. Dir...

journal_title：Seminars in cancer biology

authors： Crowther-Swanepoel D,Houlston RS

更新日期：2010-12-01 00:00:00

abstract：:Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

journal_title：Seminars in cancer biology

authors： Vallera DA

更新日期：1996-04-01 00:00:00

abstract：:Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the devel...

journal_title：Seminars in cancer biology

authors： Duffy MJ,Synnott NC,O'Grady S,Crown J

更新日期：2020-07-31 00:00:00

abstract：:Systemic treatment of renal cell carcinoma has changed dramatically since 2007, with the development and approval of six new agents, which target complex molecular pathways regulating tumour angiogenesis and cell proliferation and survival. These treatments have significantly improved survival times in metastatic rena...

journal_title：Seminars in cancer biology

authors： Fisher R,Gore M,Larkin J

更新日期：2013-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...

journal_title：Seminars in cancer biology

authors： Wang W,Kandimalla R,Huang H,Zhu L,Li Y,Gao F,Goel A,Wang X

更新日期：2019-04-01 00:00:00

abstract：:Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the r...

journal_title：Seminars in cancer biology

authors： Mantovani A,Allavena P,Sozzani S,Vecchi A,Locati M,Sica A

更新日期：2004-06-01 00:00:00

abstract：:Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...

journal_title：Seminars in cancer biology

authors： Ho SB,Kim YS

更新日期：1991-12-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...

journal_title：Seminars in cancer biology

authors： Li QK,Pavlovich CP,Zhang H,Kinsinger CR,Chan DW

更新日期：2019-04-01 00:00:00

abstract：:The frequent loss of the INK4a/ARF locus, encoding for both p16(INK4a)and p19(ARF)in human melanoma, raises the question as to which INK4a/ARF gene product functions to suppress melanoma-genesis in vivo. Studies in the mouse have shown that activated RAS mutation can cooperate with INK4a(Delta 2/3)deficiency (null for...

journal_title：Seminars in cancer biology

authors： Yang FC,Merlino G,Chin L

更新日期：2001-06-01 00:00:00