Abstract:
:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins (SIRT1-SIRT7) have multiple catalytic functions such as deacetylase, desuccinylase, demalonylase, demyristoylase, depalmitoylase, and/or mono-ADP-ribosyltransferase. They play important roles in regulating cell metabolism, especially in glucose and lipid metabolism, thereby exerting complex functions in either increasing or decreasing malignant characteristics in tumors. This review highlights the major function and its mechanisms of sirtuins in cellular metabolic reprogramming, such as glucose metabolism including aerobic glycolysis (the Warburg effect), oxidative phosphorylation (OXPHOS)/tricarboxylic acid (TCA) cycle and glutamine metabolism; lipometabolism including fatty acid metabolism, cholesterol metabolism, ketone body metabolism and acetate metabolism; as well as leucine metabolism and the urea cycle in tumorigenesis and cancer development.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui Hdoi
10.1016/j.semcancer.2018.11.003subject
Has Abstractpub_date
2019-08-01 00:00:00pages
59-71eissn
1044-579Xissn
1096-3650pii
S1044-579X(18)30107-Xjournal_volume
57pub_type
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journal_title:Seminars in cancer biology
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