Repurposing drugs in oncology: From candidate selection to clinical adoption.

abstract：:The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second...

journal_title：Seminars in cancer biology

authors： Fidler IJ

更新日期：2002-04-01 00:00:00

abstract：:Sarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made o...

journal_title：Seminars in cancer biology

authors： Burns J,Wilding CP,L Jones R,H Huang P

更新日期：2020-04-01 00:00:00

abstract：:The discovery of microRNAs (miRNAs) is one of the major scientific breakthroughs in recent years and has revolutionized the way we look at gene regulation. Although we are still at a very early stage in understanding their impact on immunity, miRNAs are changing the way we think about the development of the immune sys...

journal_title：Seminars in cancer biology

authors： Sonkoly E,Ståhle M,Pivarcsi A

更新日期：2008-04-01 00:00:00

abstract：:Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...

journal_title：Seminars in cancer biology

authors： Aiello P,Consalvi S,Poce G,Raguzzini A,Toti E,Palmery M,Biava M,Bernardi M,Kamal MA,Perry G,Peluso I

更新日期：2019-08-24 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity. Similarly, in some types of can...

journal_title：Seminars in cancer biology

authors： Engelberg D

更新日期：2004-08-01 00:00:00

abstract：:High-throughput molecular profiling of tumors is a fundamental aspect of precision oncology, enabling the identification of genomic alterations that can be targeted therapeutically. In this context, a patient is matched to a specific drug or therapy based on the tumor's underlying genetic driver events rather than the...

journal_title：Seminars in cancer biology

authors： Jäger N

更新日期：2021-01-18 00:00:00

abstract：:Growing evidence supports the notion that pharmaceutical targeting of the 5-hydroxytryptamine (5-HT) and dopamine (DA) systems offers the potential to treat human immune system disorders. This review describes this emerging area of research, which has the benefit of being supported by a relatively detailed understandi...

journal_title：Seminars in cancer biology

authors： Barnes NM,Gordon J

更新日期：2008-06-01 00:00:00

abstract：:Intellectual property documents (patents and their published applications) are not only collections of legal exclusivity claims but also repositories of scientific and technical information, even though they are not peer reviewed. We have identified and analyzed international disclosures concerning drug repurposing fo...

journal_title：Seminars in cancer biology

authors： Mucke HAM

更新日期：2019-09-20 00:00:00

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...

journal_title：Seminars in cancer biology

authors： Patarroyo M,Tryggvason K,Virtanen I

更新日期：2002-06-01 00:00:00

abstract：:Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors. Cellular "morphinergic" signaling is predominantly targeted to autocrine/paracrine regulatory processes and is reciprocally linked to stimulate...

journal_title：Seminars in cancer biology

authors： Stefano GB,Kream R

更新日期：2008-06-01 00:00:00

abstract：:The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

journal_title：Seminars in cancer biology

authors： Wang H,Maitra A,Wang H

更新日期：2016-02-01 00:00:00

abstract：:Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular pr...

journal_title：Seminars in cancer biology

authors： Gordeeva O

更新日期：2018-12-01 00:00:00

abstract：:SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertio...

journal_title：Seminars in cancer biology

authors： Hancks DC,Kazazian HH Jr

更新日期：2010-08-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...

journal_title：Seminars in cancer biology

authors： Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar T

更新日期：2005-10-01 00:00:00

abstract：:The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

journal_title：Seminars in cancer biology

authors： Ponzio NM,Thorbecke GJ

更新日期：2000-10-01 00:00:00

abstract：:Natural killer (NK) cells have important functions in the innate immunity to tumors. Recognition of tumor cells by NK cells is mediated by the interaction of activating and inhibitory NK cell receptors with ligands expressed on the tumor target. In addition, NK cell-target cell interactions require the engagement of a...

journal_title：Seminars in cancer biology

authors： Fuchs A,Colonna M

更新日期：2006-10-01 00:00:00

abstract：:The p53 tumor suppressor is the most commonly mutated gene in human cancer. p53 protein is stabilized in response to different checkpoints activated by DNA damage, hypoxia, viral infection, or oncogene activation resulting in diverse biological effects, such as cell cycle arrest, apoptosis, senescence, differentiation...

journal_title：Seminars in cancer biology

authors： el-Deiry WS

更新日期：1998-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common histological form of primary liver cancer; the tumor cells having retained features of hepatocytic differentiation. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs complicate the evolution of an activ...

journal_title：Seminars in cancer biology

authors： Bréchot C,Gozuacik D,Murakami Y,Paterlini-Bréchot P

更新日期：2000-06-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...

journal_title：Seminars in cancer biology

authors： Li QK,Pavlovich CP,Zhang H,Kinsinger CR,Chan DW

更新日期：2019-04-01 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins...

journal_title：Seminars in cancer biology

authors： Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui H

更新日期：2019-08-01 00:00:00

abstract：:Systemic treatment of renal cell carcinoma has changed dramatically since 2007, with the development and approval of six new agents, which target complex molecular pathways regulating tumour angiogenesis and cell proliferation and survival. These treatments have significantly improved survival times in metastatic rena...

journal_title：Seminars in cancer biology

authors： Fisher R,Gore M,Larkin J

更新日期：2013-02-01 00:00:00

abstract：:Data obtained from cutting-edge research have shown that deregulated epigenetic marks are critical hallmarks of cancer. Rapidly emerging scientific evidence has helped in developing a proper understanding of the mechanisms leading to control of cellular functions, from changes in chromatin accessibility, transcription...

journal_title：Seminars in cancer biology

authors： Farooqi AA,Fayyaz S,Poltronieri P,Calin G,Mallardo M

更新日期：2020-07-30 00:00:00

abstract：:Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes in...

journal_title：Seminars in cancer biology

authors： Steinbichler TB,Dudás J,Riechelmann H,Skvortsova II

更新日期：2017-06-01 00:00:00

abstract：:Over the last decade, the development and progress of next-generation sequencers incorporated with classical biochemical analyses have drastically produced novel insights into transcription factors, including Sry-like high-mobility group box (SOX) factors. In addition to their primary functions in binding to and activ...

journal_title：Seminars in cancer biology

authors： Higashijima Y,Kanki Y

更新日期：2020-12-01 00:00:00

abstract：:The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studie...

journal_title：Seminars in cancer biology

authors： de Vries A,van Steeg H

更新日期：1996-10-01 00:00:00

abstract：:DNA copy number amplifications activate oncogenes and are found in the majority of advanced solid tumors. Cell-lineage specificity and oncogene affinity of DNA amplifications in cancer suggest that properties of precursor stem cells and selection pressure in the tissue micro-environment determine the genomic location ...

journal_title：Seminars in cancer biology

authors： Myllykangas S,Böhling T,Knuutila S

更新日期：2007-02-01 00:00:00