Abstract：
:Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biological basis of splenic marginal zone lymphoma by providing a comprehensive and unbiased view of the genes/pathways that are deregulated in this disease. NF-κB is a family of transcription factors that plays critical roles in development, survival, and activation of B lymphocytes. Consistent with the physiological involvement of NF-κB signalling in proliferation and commitment of mature B-cells to the marginal zone of the spleen, many oncogenic mutations involved in constitutive activation of the NF-κB pathway were recently identified in splenic marginal zone lymphoma. This review describes the progress in understanding the mechanism of NF-κB activation in splenic marginal zone lymphoma, including molecular, epigenetic and post-transcriptional modifications of NF-κB genes and of upstream pathways, and discusses how information gained from these efforts has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance for splenic marginal zone lymphoma.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Spina V,Rossi Ddoi
10.1016/j.semcancer.2016.08.002subject
Has Abstractpub_date
2016-08-01 00:00:00pages
61-7eissn
1044-579Xissn
1096-3650pii
S1044-579X(16)30033-5journal_volume
39pub_type
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journal_title：Seminars in cancer biology
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journal_title：Seminars in cancer biology
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doi：
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journal_title：Seminars in cancer biology
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更新日期：2018-12-01 00:00:00
