Genetic control of the metastatic phenotype.

Abstract:

:Transfection experiments indicate that a number of genes can induce or suppress the metastatic phenotype. These genes include ten oncogenes, plasminogen activator, and three suppressor genes. The biochemical mechanism(s) whereby each of these genes alters the metastatic phenotype is poorly understood. Hypotheses concerning the coordinate regulation of metastasis-effector genes, and the relationship of gene expression in metastasis to that in embryonic development are discussed.

journal_name

Semin Cancer Biol

authors

Steeg PS

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

105-10

issue

2

eissn

1044-579X

issn

1096-3650

journal_volume

2

pub_type

杂志文章,评审
  • Novel functions of interferon-induced proteins.

    abstract::Interferons are important cytokines which regulate antiviral, cell growth, immune modulatory and anti-tumor functions. These pleiotropic effects of interferons are brought about by a large number of cellular proteins, the interferon-inducible proteins. Investigation of the biochemical and cellular activities of some o...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2000.0312

    authors: Sen GC

    更新日期:2000-04-01 00:00:00

  • Clinical significance of the Thomsen-Friedenreich antigen.

    abstract::What is the clinical significance of the expression by common human carcinomas of the Thomsen-Friedenreich (TF) antigen? Described as a terminal disaccharide which is a precursor of MN blood group antigens, it was discovered as a laboratory curiosity 60 years ago, yet its cancer-association has only been appreciated i...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: MacLean GD,Longenecker BM

    更新日期:1991-12-01 00:00:00

  • An update on vitamin D signaling and cancer.

    abstract::A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2020.05.018

    authors: Carlberg C,Muñoz A

    更新日期:2020-05-30 00:00:00

  • Mammary tumorigenesis and metastasis in transgenic mice.

    abstract::The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Webster MA,Muller WJ

    更新日期:1994-02-01 00:00:00

  • Intracellular signaling by cathepsin X: molecular mechanisms and diagnostic and therapeutic opportunities in cancer.

    abstract::Cathepsin X is a cysteine carboxypeptidase, localized predominantly in immune cells, regulating their proliferation, maturation, migration and adhesion. It has recently been confirmed as a significant promoter of malignant progression. Its role in signal transduction was first implied through the interaction with inte...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2014.05.001

    authors: Kos J,Vižin T,Fonović UP,Pišlar A

    更新日期:2015-04-01 00:00:00

  • Translational genomics and recent advances in oral squamous cell carcinoma.

    abstract::Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor r...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.09.011

    authors: Chai AWY,Lim KP,Cheong SC

    更新日期:2020-04-01 00:00:00

  • Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.

    abstract::A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, c...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2007.08.004

    authors: O'Neill GM,Stehn J,Gunning PW

    更新日期:2008-02-01 00:00:00

  • PIWI-interacting RNAs in human cancer.

    abstract::P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.08.012

    authors: Lin Y,Zheng J,Lin D

    更新日期:2020-09-01 00:00:00

  • T antigen transgenic mouse models.

    abstract::The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2009.02.002

    authors: Sáenz Robles MT,Pipas JM

    更新日期:2009-08-01 00:00:00

  • The role of peptide presentation in the physiological function of HLA-G.

    abstract::The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1998.0105

    authors: Münz C,Nickolaus P,Lammert E,Pascolo S,Stevanović S,Rammensee HG

    更新日期:1999-02-01 00:00:00

  • RNA interference: gene silencing in the fast lane.

    abstract::Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1044-579x(03)00039-7

    authors: Kittler R,Buchholz F

    更新日期:2003-08-01 00:00:00

  • The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

    abstract::Recently, work on the mechanism of action of the von Hippel-Lindau tumour suppressor protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights into both cellular oxygen sensing and cancer pathogenesis. pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the d...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1044-579x(02)00103-7

    authors: Pugh CW,Ratcliffe PJ

    更新日期:2003-02-01 00:00:00

  • Cytotoxic T lymphocyte therapy of cancer and tumor escape mechanisms.

    abstract::In animal models complete and permanent eradication of tumors can be achieved by adoptive transfer of tumor specific T cells, combined with interleukin 2. The most active cells are CD8+ cytotoxic T lymphocytes (CTL), which recognize peptides of 8-10 amino acids in length, bound to the antigen presenting groove of MHC ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Melief CJ,Kast WM

    更新日期:1991-10-01 00:00:00

  • Nanotechnology, in silico and endocrine-based strategy for delivering paclitaxel and miRNA: Prospects for the therapeutic management of breast cancer.

    abstract::Breast cancer is one of the most prevalent and reoccurring cancers and the second most common reason of death in women. Despite advancements in therapeutic strategies for breast cancer, early tumor recurrence and metastasis in patients indicate resistance to chemotherapeutic medicines, such as paclitaxel due to the ab...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.12.022

    authors: Ansari MA,Thiruvengadam M,Farooqui Z,Rajakumar G,Sajid Jamal QM,Alzohairy MA,Almatroudi A,Alomary MN,Chung IM,Al-Suhaimi EA

    更新日期:2019-12-28 00:00:00

  • Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions.

    abstract::Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1044-579x(03)00015-4

    authors: Lossos IS,Levy R

    更新日期:2003-06-01 00:00:00

  • Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer.

    abstract::Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in cancer related mortality in men in most Western industrialized countries. Androgen and androgen receptor (AR) are the dominant modulators of PCa growth. Over the last two decades multiple advancements in screening, treatment, sur...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2016.06.003

    authors: Kallifatidis G,Hoy JJ,Lokeshwar BL

    更新日期:2016-10-01 00:00:00

  • Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

    abstract::DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2014.06.002

    authors: Skvortsov S,Debbage P,Lukas P,Skvortsova I

    更新日期:2015-04-01 00:00:00

  • The emerging roles of F-box proteins in pancreatic tumorigenesis.

    abstract::The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2015.09.004

    authors: Wang H,Maitra A,Wang H

    更新日期:2016-02-01 00:00:00

  • Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease.

    abstract::Small cell lung cancer (SCLC) is a particular subtype of lung cancer with high mortality. Recent advances in understanding SCLC genomics and breakthroughs of immunotherapy have substantially expanded existing knowledge and treatment modalities. However, challenges associated with SCLC remain enigmatic and elusive. Mos...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.11.006

    authors: Khan P,Siddiqui JA,Maurya SK,Lakshmanan I,Jain M,Ganti AK,Salgia R,Batra SK,Nasser MW

    更新日期:2020-11-18 00:00:00

  • Immunotherapy of cancer using cytokine gene-modified tumor vaccines.

    abstract::Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Gilboa E,Lyerly HK,Vieweg J,Saito S

    更新日期:1994-12-01 00:00:00

  • Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

    abstract::Dietary flavonoids and other polyphenols show great potential as cancer chemopreventive agents in cell culture studies. This does not translate well into in vivo activity, because of extensive conjugative metabolism of these compounds in the intestine and liver. This paper presents a review of a flavonoid subclass in ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2007.05.002

    authors: Walle T

    更新日期:2007-10-01 00:00:00

  • From autophagic to necrotic cell death in Dictyostelium.

    abstract::Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vac...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2006.10.010

    authors: Tresse E,Kosta A,Luciani MF,Golstein P

    更新日期:2007-04-01 00:00:00

  • Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma.

    abstract::Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0023

    authors: Niedobitek G,Agathanggelou A,Nicholls JM

    更新日期:1996-08-01 00:00:00

  • The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.

    abstract::Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation a...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2017.06.001

    authors: Huynh J,Etemadi N,Hollande F,Ernst M,Buchert M

    更新日期:2017-08-01 00:00:00

  • Growing evidence that several human cancers may originate in utero.

    abstract::Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1998.0073

    authors: Ekbom A

    更新日期:1998-08-01 00:00:00

  • The bcl-2 gene family.

    abstract::Viability is a fundamental determinant of all cellular functions, and regulation of cell viability is important in shaping tissue differentiation and organism development. The genes in the bcl-2 family can profoundly influence cell viability. In addition to bcl-2, cellular genes in this family include bcl-x, bax, mcl-...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1995.0005

    authors: Craig RW

    更新日期:1995-02-01 00:00:00

  • Genomics of gynaecological carcinosarcomas and future treatment options.

    abstract::Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.10.006

    authors: Barker HE,Scott CL

    更新日期:2020-04-01 00:00:00

  • Tumor invasion as dysregulated cell motility.

    abstract::Investigations across a range of disciplines over the past decade have brought the study of cell motility and its role in invasion to an exciting threshold. The biophysical forces proximally involved in generating cell locomotion, as well as the underlying signaling and genomic regulatory processes, are gradually beco...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2000.0362

    authors: Kassis J,Lauffenburger DA,Turner T,Wells A

    更新日期:2001-04-01 00:00:00

  • Relationship of p53 to the control of apoptotic cell death.

    abstract::While the centrality of aberrant cell proliferation in cancer was widely acknowledged long ago, it is only recently that the control of cell death has been recognized as an important target in carcinogenesis. Various lines of evidence now suggest that p53 is a positive regulator of cell death, and particularly of apop...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Oren M

    更新日期:1994-06-01 00:00:00

  • Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment.

    abstract::Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2004.08.001

    authors: Sloane BF,Yan S,Podgorski I,Linebaugh BE,Cher ML,Mai J,Cavallo-Medved D,Sameni M,Dosescu J,Moin K

    更新日期:2005-04-01 00:00:00