Abstract:
:Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-specific expression and are differentially recognized by integrins. Expression of laminin isoforms in tumors usually reflects expression in their normal counterparts. However, during tumor invasion, loss of the BM barrier occurs and a discontinuous pattern of laminin staining is observed. In carcinomas, tumor cells at the invading front strongly express intracellularly the gamma2 chain, a component of laminin-5. Remodeling of the vascular BM is observed during angiogenesis, and penetration of several BMs occurs during tumor dissemination and metastasis. Thus, disregulated cell-laminin interactions are major traits of malignant disorders.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Patarroyo M,Tryggvason K,Virtanen Idoi
10.1016/S1044-579X(02)00023-8keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
197-207issue
3eissn
1044-579Xissn
1096-3650pii
S1044-579X(02)00023-8journal_volume
12pub_type
杂志文章,评审abstract::Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...
journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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更新日期:2020-11-01 00:00:00
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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