The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

abstract：:The molecular events underlying prostatic tumorigenesis remain incompletely understood. The application of cytogenetic, molecular genetic and molecular cytogenetic techniques have led to the identification of consistent genetic changes. This paper will discuss these techniques, review the genetic aberrations discovere...

journal_title：Seminars in cancer biology

authors： Roylance R,Spurr N,Sheer D

更新日期：1997-02-01 00:00:00

abstract：:Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation a...

journal_title：Seminars in cancer biology

authors： Huynh J,Etemadi N,Hollande F,Ernst M,Buchert M

更新日期：2017-08-01 00:00:00

abstract：:Raf-1 belongs to a family of serine/threonine protein kinases which are highly conserved through evolution in multicellular organisms. Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane t...

journal_title：Seminars in cancer biology

authors： Magnuson NS,Beck T,Vahidi H,Hahn H,Smola U,Rapp UR

更新日期：1994-08-01 00:00:00

abstract：:Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...

journal_title：Seminars in cancer biology

authors： Ho SB,Kim YS

更新日期：1991-12-01 00:00:00

abstract：:Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

journal_title：Seminars in cancer biology

authors： Kittler R,Buchholz F

更新日期：2003-08-01 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has m...

journal_title：Seminars in cancer biology

authors： Alaseem A,Alhazzani K,Dondapati P,Alobid S,Bishayee A,Rathinavelu A

更新日期：2019-06-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and...

journal_title：Seminars in cancer biology

authors： Gabriely G,Quintana FJ

更新日期：2020-08-01 00:00:00

abstract：:We have recently shown that natural killer (NK) cells select and differentiate cancer stem cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) and TNF-alpha (TNF-α), preventing tumor growth and inducing remodeling of the tumor microenvironment. Since many conventional therapeutic str...

journal_title：Seminars in cancer biology

authors： Jewett A,Kos J,Fong Y,Ko MW,Safaei T,Perišić Nanut M,Kaur K

更新日期：2018-12-01 00:00:00

abstract：:Growing evidence supports the notion that pharmaceutical targeting of the 5-hydroxytryptamine (5-HT) and dopamine (DA) systems offers the potential to treat human immune system disorders. This review describes this emerging area of research, which has the benefit of being supported by a relatively detailed understandi...

journal_title：Seminars in cancer biology

authors： Barnes NM,Gordon J

更新日期：2008-06-01 00:00:00

abstract：:Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. A positive family history of breast cancer is one of the strongest risk factors for the disease. In addition, many afflicted breast cancer families are characterized by early onset and bilateral tumors, and also, in som...

journal_title：Seminars in cancer biology

authors： Arver B,Du Q,Chen J,Luo L,Lindblom A

更新日期：2000-08-01 00:00:00

abstract：:Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics be...

journal_title：Seminars in cancer biology

authors： Dworkin AM,Huang TH,Toland AE

更新日期：2009-06-01 00:00:00

abstract：:The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechan...

journal_title：Seminars in cancer biology

authors： Sher G,Salman NA,Khan AQ,Prabhu KS,Raza A,Kulinski M,Dermime S,Haris M,Junejo K,Uddin S

更新日期：2020-08-25 00:00:00

abstract：:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ...

journal_title：Seminars in cancer biology

authors： Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus A

更新日期：2000-02-01 00:00:00

abstract：:Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes in...

journal_title：Seminars in cancer biology

authors： Steinbichler TB,Dudás J,Riechelmann H,Skvortsova II

更新日期：2017-06-01 00:00:00

abstract：:Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes a...

journal_title：Seminars in cancer biology

authors： Simula L,Nazio F,Campello S

更新日期：2017-12-01 00:00:00

abstract：:Chronic lymphocytic leukaemia (CLL) is the most common form of lymphoid malignancy in Western countries, accounting for around a quarter of all leukaemias. Evidence from epidemiological and family studies have provided evidence for familial clustering of CLL compatible with inherited genetic predisposition to CLL. Dir...

journal_title：Seminars in cancer biology

authors： Crowther-Swanepoel D,Houlston RS

更新日期：2010-12-01 00:00:00

abstract：:Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

journal_title：Seminars in cancer biology

authors： Vallera DA

更新日期：1996-04-01 00:00:00

abstract：:The development of vaccines for melanoma has been accelerated by the identification of melanoma-associated antigens, a better understanding of basic immunologic principles, and the ability to construct complex vectors for immunization. The location and context in which T-cell priming occurs significantly influences th...

journal_title：Seminars in cancer biology

authors： Hörig H,Kaufman HL

更新日期：2003-12-01 00:00:00

abstract：:Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regul...

journal_title：Seminars in cancer biology

authors： Sukocheva OA,Lukina E,Friedemann M,Menschikowski M,Hagelgans A,Aliev G

更新日期：2020-12-07 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:Different types of RNAs identified thus far represent a diverse group of macromolecules that are involved in the regulation of different biological processes. RNA is generally thought to be localized primarily in the nucleus and cytoplasm; however, some types of RNA have been detected in the extracellular milieu. Thes...

journal_title：Seminars in cancer biology

authors： Redzic JS,Balaj L,van der Vos KE,Breakefield XO

更新日期：2014-10-01 00:00:00

abstract：:Investigations across a range of disciplines over the past decade have brought the study of cell motility and its role in invasion to an exciting threshold. The biophysical forces proximally involved in generating cell locomotion, as well as the underlying signaling and genomic regulatory processes, are gradually beco...

journal_title：Seminars in cancer biology

authors： Kassis J,Lauffenburger DA,Turner T,Wells A

更新日期：2001-04-01 00:00:00

abstract：:The two major breast cancer susceptibility genes, BRCA1 and BRCA2, account for the majority of familial breast-ovarian cancer, but only a modest proportion of breast cancer families without ovarian or male breast cancer. Search for additional breast cancer genes with traditional linkage analysis has so far been unsucc...

journal_title：Seminars in cancer biology

authors： Borg A

更新日期：2001-10-01 00:00:00

abstract：:P-element-induced wimpy testis (PIWI) interacting RNAs (piRNAs) are a class of small regulatory RNAs mechanistically similar to but much less studied than microRNAs and small interfering RNAs. Today the best understood function of piRNAs is transposon control in animal germ cells, which has earned them the name 'guard...

journal_title：Seminars in cancer biology

authors： Lin Y,Zheng J,Lin D

更新日期：2020-09-01 00:00:00

abstract：:The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...

journal_title：Seminars in cancer biology

authors： Münz C,Nickolaus P,Lammert E,Pascolo S,Stevanović S,Rammensee HG

更新日期：1999-02-01 00:00:00

abstract：:The dysregulation of apoptosis is a key step in developing cancers, and mediates resistance to cancer therapy. Commitment to apoptosis is caused by permeabilization of the outer mitochondrial membrane, a process regulated by the interactions between different proteins of Bcl-2 family. Furthermore, Bcl-2 family protein...

journal_title：Seminars in cancer biology

authors： Yu L,Liu S

更新日期：2013-12-01 00:00:00

abstract：:Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...

journal_title：Seminars in cancer biology

authors： Brandt B,Heyder C,Gloria-Maercker E,Hatzmann W,Rötger A,Kemming D,Zänker KS,Entschladen F,Dittmar T

更新日期：2005-10-01 00:00:00

abstract：:Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the liver. Despite the identification of the early driver mutations during the development of the pathology, the process of UM metastasis is still not fully comprehended. A better understanding of the genetic, molecular, and environ...

journal_title：Seminars in cancer biology

authors： Bustamante P,Piquet L,Landreville S,Burnier JV

更新日期：2020-05-22 00:00:00