Abstract:
:Mitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes are frequently encountered in cancer, during both its onset and later progression, as evidence emerge connecting alterations in mitochondrial dynamics with cancer development. In recent years, novel therapeutic approaches to fight against different human tumors aim at exploiting the immune system's ability to specifically recognize tumor antigens, thus killing malignant cells in a process named immune-surveillance. Interestingly, data are accumulating on the role that mitochondrial dynamics play also for the correct function of both the innate and the adaptive immune system. By this review, we overview how mitochondrial dynamics can affect various processes during cancer development, acting directly on tumor cells or indirectly on cells responsible for tumor aggression and defence.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Simula L,Nazio F,Campello Sdoi
10.1016/j.semcancer.2017.06.007subject
Has Abstractpub_date
2017-12-01 00:00:00pages
29-42eissn
1044-579Xissn
1096-3650pii
S1044-579X(17)30163-3journal_volume
47pub_type
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2016.08.001
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.07.002
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.12.001
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2020.12.020
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1998.0116
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1996.0009
更新日期:1996-04-01 00:00:00
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.2001.0416
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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journal_title:Seminars in cancer biology
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
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journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.06.004
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