Bioinformatics workflows for clinical applications in precision oncology.

abstract：:There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...

journal_title：Seminars in cancer biology

authors： Khazaie K,von Boehmer H

更新日期：2006-04-01 00:00:00

abstract：:Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads ...

journal_title：Seminars in cancer biology

authors： Lossos IS,Levy R

更新日期：2003-06-01 00:00:00

abstract：:The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...

journal_title：Seminars in cancer biology

authors： Münz C,Nickolaus P,Lammert E,Pascolo S,Stevanović S,Rammensee HG

更新日期：1999-02-01 00:00:00

abstract：:Neoplasms progress to cancer through a process of natural selection. The rate of evolution, and thus progression is determined by three parameters: mutation rate, population size of the evolving neoplastic cells, and intensity of selection or rate of clonal expansion. All three parameters are reviewed in the context o...

journal_title：Seminars in cancer biology

authors： Maley CC,Reid BJ

更新日期：2005-12-01 00:00:00

abstract：:The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

journal_title：Seminars in cancer biology

authors： Whyte P

更新日期：1995-04-01 00:00:00

abstract：:System approaches in biology have a long history. We focus here on the thinking of Paul A. Weiss and Ludwig von Bertalanffy, who contributed a great deal towards making the system concept operable in biology in the early 20th century. To them, considering whole living systems, which includes their organisation or orde...

journal_title：Seminars in cancer biology

authors： Drack M,Wolkenhauer O

更新日期：2011-06-01 00:00:00

abstract：:Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ...

journal_title：Seminars in cancer biology

authors： Radvány Z,Darvas Z,Kerekes K,Prechl J,Szalai C,Pállinger E,Valéria L,Varga VL,Sandor M,Erdei A,Falus A

更新日期：2000-02-01 00:00:00

abstract：:The B-cell receptor (BCR) is essential for normal B-cell development and maturation. In an increasing number of B-cell malignancies, BCR signaling is implicated as a pivotal pathway in tumorigenesis. Mechanisms of BCR activation are quite diverse and range from chronic antigenic drive by microbial or viral antigens to...

journal_title：Seminars in cancer biology

authors： Niemann CU,Wiestner A

更新日期：2013-12-01 00:00:00

abstract：:Altering energy metabolism to meet the uncontrolled proliferation and metastasis has emerged as one of the most significant hallmarks in tumors. However, the detailed molecular mechanisms and regulatory actions underlying have not been fully elucidated. As a family of NAD+ dependent protein modifying enzymes, sirtuins...

journal_title：Seminars in cancer biology

authors： Zhu S,Dong Z,Ke X,Hou J,Zhao E,Zhang K,Wang F,Yang L,Xiang Z,Cui H

更新日期：2019-08-01 00:00:00

abstract：:As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...

journal_title：Seminars in cancer biology

authors： Schwartz L,Seyfried T,Alfarouk KO,Da Veiga Moreira J,Fais S

更新日期：2017-04-01 00:00:00

abstract：:Tumor cell invasion is now viewed as dysregulated physiologic invasion. Investigators have started to define the molecular events that are involved in this process. We find that there are many functional similarities with molecular events involved in physiologic process such as angiogenesis and wound healing. Matrix m...

journal_title：Seminars in cancer biology

authors： Stetler-Stevenson WG,Hewitt R,Corcoran M

更新日期：1996-06-01 00:00:00

abstract：:Gene vectors with an untargeted insertion profile have been explored in preclinical models and clinical trials for the transfer of potentially therapeutic genetic information into somatic cells that have a high replicative potential. The gene-modified cell population can be viewed as a genetic mosaic whose complexity ...

journal_title：Seminars in cancer biology

authors： Kustikova O,Brugman M,Baum C

更新日期：2010-08-01 00:00:00

abstract：:The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

journal_title：Seminars in cancer biology

authors： Ponzio NM,Thorbecke GJ

更新日期：2000-10-01 00:00:00

abstract：:Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...

journal_title：Seminars in cancer biology

authors： Barker HE,Scott CL

更新日期：2020-04-01 00:00:00

abstract：:The dysregulation of apoptosis is a key step in developing cancers, and mediates resistance to cancer therapy. Commitment to apoptosis is caused by permeabilization of the outer mitochondrial membrane, a process regulated by the interactions between different proteins of Bcl-2 family. Furthermore, Bcl-2 family protein...

journal_title：Seminars in cancer biology

authors： Yu L,Liu S

更新日期：2013-12-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular proteins. Targeting protein degradation has been validated as an effective strategy for cancer therapy since 2003. Several components of the UPS have been validated as potential anticancer targets, including 20S proteasomes, 19S ...

journal_title：Seminars in cancer biology

authors： Yang H,Chen X,Li K,Cheaito H,Yang Q,Wu G,Liu J,Dou QP

更新日期：2019-12-26 00:00:00

abstract：:Amino-bisphosphonates (N-BPs) have been commercially available for over four decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of malignancy, and bone metastases derived from various cancer types. Zoledronate and alendronate, two of the most potent N-BPs, have demonstrated direct t...

journal_title：Seminars in cancer biology

authors： La-Beck NM,Liu X,Shmeeda H,Shudde C,Gabizon AA

更新日期：2019-12-23 00:00:00

abstract：:The escalating epidemic of overweight and obesity is currently recognized as one of the most significant health and economic concern worldwide. At the present time, over 1.9 billion adults and more than 600 million people can be, respectively, classified as overweight or obese, and numbers will continue to increase in...

journal_title：Seminars in cancer biology

authors： Barone I,Giordano C,Bonofiglio D,Andò S,Catalano S

更新日期：2020-02-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:Recently, work on the mechanism of action of the von Hippel-Lindau tumour suppressor protein (pVHL) and studies on hypoxic gene regulation have converged, providing insights into both cellular oxygen sensing and cancer pathogenesis. pVHL is the recognition component of the E3-ubiquitin ligase complex involved in the d...

journal_title：Seminars in cancer biology

authors： Pugh CW,Ratcliffe PJ

更新日期：2003-02-01 00:00:00

abstract：:Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular pr...

journal_title：Seminars in cancer biology

authors： Gordeeva O

更新日期：2018-12-01 00:00:00

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

journal_title：Seminars in cancer biology

authors： Carlberg C,Muñoz A

更新日期：2020-05-30 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

journal_title：Seminars in cancer biology

authors： Laconi E,Doratiotto S,Vineis P

更新日期：2008-10-01 00:00:00

abstract：:Hyaluronan is a megadalton glycosaminoglycan polymer critical for maintaining the integrity of the extracellular matrix. It can exist in a protein-bound state with aggregating proteoglycans, where it expands the extracellular matrix and modulates cell-cell interactions. It also exists in lower molecular weight forms t...

journal_title：Seminars in cancer biology

authors： Stern R

更新日期：2008-08-01 00:00:00

abstract：:The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusio...

journal_title：Seminars in cancer biology

authors： Colmenares C,Stavnezer E

更新日期：1990-12-01 00:00:00

abstract：:Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...

journal_title：Seminars in cancer biology

authors： Kemp CJ

更新日期：2005-12-01 00:00:00

abstract：:In this paper, we provide an overview of targeted anticancer therapies with small molecule kinase inhibitors. First, we discuss why a single constitutively active kinase emanating from a variety of aberrant genetic alterations is capable of transforming a normal cell, leading it to acquire the hallmarks of a cancer ce...

journal_title：Seminars in cancer biology

authors： Tsai CJ,Nussinov R

更新日期：2013-08-01 00:00:00

abstract：:T cells of the adaptive immune system monitor protein degradation products via their presentation on major histocompatibility complex (MHC) molecules to recognize infected cells. Both macroautophagy and endocytosis target intra- and extracellular constituents, respectively, for lysosomal degradation. This results in a...

journal_title：Seminars in cancer biology

authors： Münz C

更新日期：2020-11-01 00:00:00