Familial nasopharyngeal carcinoma.

Abstract:

:Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried out in the previous decades and vast information was accumulated for familiar NPC, in terms of risk factors, inheritance mode, and involvement of gene polymorphisms. The major findings in this field were summarized. Furthermore, future directions leading to understanding the genetic mechanism of the familial form of NPC was also discussed.

journal_name

Semin Cancer Biol

authors

Zeng YX,Jia WH

doi

10.1016/s1044579x02000871

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

443-50

issue

6

eissn

1044-579X

issn

1096-3650

pii

S1044579X02000871

journal_volume

12

pub_type

杂志文章,评审
  • Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies.

    abstract::Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (ove...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2016.03.004

    authors: Mantso T,Goussetis G,Franco R,Botaitis S,Pappa A,Panayiotidis M

    更新日期:2016-06-01 00:00:00

  • Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment.

    abstract::While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2017.03.004

    authors: Dumas JF,Brisson L,Chevalier S,Mahéo K,Fromont G,Moussata D,Besson P,Roger S

    更新日期:2017-04-01 00:00:00

  • MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation.

    abstract::The discovery of microRNAs (miRNAs) is one of the major scientific breakthroughs in recent years and has revolutionized the way we look at gene regulation. Although we are still at a very early stage in understanding their impact on immunity, miRNAs are changing the way we think about the development of the immune sys...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2008.01.005

    authors: Sonkoly E,Ståhle M,Pivarcsi A

    更新日期:2008-04-01 00:00:00

  • Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.

    abstract::A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, c...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2007.08.004

    authors: O'Neill GM,Stehn J,Gunning PW

    更新日期:2008-02-01 00:00:00

  • Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers.

    abstract::More than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-s...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.08.026

    authors: Zhao Y,Li J,Li D,Wang Z,Zhao J,Wu X,Sun Q,Lin PP,Plum P,Damanakis A,Gebauer F,Zhou M,Zhang Z,Schlösser H,Jauch KW,Nelson PJ,Bruns CJ

    更新日期:2020-02-01 00:00:00

  • Tumour escape from immune surveillance through dendritic cell inactivation.

    abstract::Dendritic cells (DC) are central to the initiation of immunity. To induce immune reactivity, DC are recruited at the site of antigen expression, uptake antigens and migrate to secondary lymphoid organs while receiving activation signals delivered by pathogens, dying cells, and/or T cells. Tumours can escape the immune...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2001.0400

    authors: Vicari AP,Caux C,Trinchieri G

    更新日期:2002-02-01 00:00:00

  • Growing evidence that several human cancers may originate in utero.

    abstract::Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1998.0073

    authors: Ekbom A

    更新日期:1998-08-01 00:00:00

  • The crucial role of epigenetic regulation in breast cancer anti-estrogen resistance: Current findings and future perspectives.

    abstract::Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regul...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.12.004

    authors: Sukocheva OA,Lukina E,Friedemann M,Menschikowski M,Hagelgans A,Aliev G

    更新日期:2020-12-07 00:00:00

  • NanoString in the screening of genetic abnormalities associated with thyroid cancer.

    abstract::In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clini...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2020.10.004

    authors: Macerola E,Poma AM,Basolo F

    更新日期:2020-10-19 00:00:00

  • Xenophagy in cancer.

    abstract::Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.02.015

    authors: Ammanathan V,Vats S,Abraham IM,Manjithaya R

    更新日期:2020-11-01 00:00:00

  • The kinship of neutrophils and granulocytic myeloid-derived suppressor cells in cancer: cousins, siblings or twins?

    abstract::Neutrophils in the tumor host may promote tumor progression by enhancing angiogenesis, invasion and metastasis. Granulocytic myeloid-derived suppressor cells (MDSC) share many features with neutrophils. Classically, MDSC are viewed as and defined as immunosuppressive cells. In this article we summarize and critically ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2013.02.007

    authors: Brandau S,Moses K,Lang S

    更新日期:2013-06-01 00:00:00

  • Gut microbiome: A possible common therapeutic target for treatment of atherosclerosis and cancer.

    abstract::Human gut microbiota is a dynamic and variable system that can change over time and in response to different diets and treatments. There is currently no doubt that gut microbiota can provide interesting therapeutic opportunities, since it can metabolize biologically active molecules, drugs, and their precursors, and c...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.06.017

    authors: Wu WK,Ivanova EA,Orekhov AN

    更新日期:2020-06-28 00:00:00

  • Role of cell surface proteoglycans in cancer immunotherapy.

    abstract::Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against ch...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.07.012

    authors: Espinoza-Sánchez NA,Götte M

    更新日期:2020-05-01 00:00:00

  • Predicting liver metastases growth patterns: Current status and future possibilities.

    abstract::Colorectal cancer is highly incident worldwide and presents a health burden with elevated mortality rate despite prevention, detection, and treatment, mainly due to metastatic liver disease. Histological growth patterns of colorectal cancer liver metastases have emerged as a reproducible prognostic factor, with biolog...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.07.007

    authors: Oliveira RC,Alexandrino H,Cipriano MA,Alves FC,Tralhão JG

    更新日期:2020-07-14 00:00:00

  • An update on vitamin D signaling and cancer.

    abstract::A low vitamin D status is associated with an increased risk of various cancers, such as of colon, breast, prostate and hematological cells. The biologically most active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a high affinity ligand of the transcription factor vitamin D receptor (VDR). 1,25(OH)2...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2020.05.018

    authors: Carlberg C,Muñoz A

    更新日期:2020-05-30 00:00:00

  • RNA interference: gene silencing in the fast lane.

    abstract::Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1044-579x(03)00039-7

    authors: Kittler R,Buchholz F

    更新日期:2003-08-01 00:00:00

  • Cathepsin B and cystatins: evidence for a role in cancer progression.

    abstract::The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and rodent tumors. These increases in cathepsin B activity correspond in part...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Sloane BF

    更新日期:1990-04-01 00:00:00

  • SVA retrotransposons: Evolution and genetic instability.

    abstract::SINE-VNTR-Alus (SVA) are non-autonomous hominid specific retrotransposons that are associated with disease in humans. SVAs are evolutionarily young and presumably mobilized by the LINE-1 reverse transcriptase in trans. SVAs are currently active and may impact the host through a variety of mechanisms including insertio...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2010.04.001

    authors: Hancks DC,Kazazian HH Jr

    更新日期:2010-08-01 00:00:00

  • MicroRNA regulation of TRAIL mediated signaling in different cancers: Control of micro steering wheels during the journey from bench-top to the bedside.

    abstract::Large-scale sequencing methodologies have helped us identify numerous genomic alterations and we have started to scratch the surface of many new targets for treatment of cancer and the associated predictive biomarkers. TRAIL (TNF-related apoptosis-inducing ligand) is a highly appreciated anti-cancer molecule because o...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.01.007

    authors: Fayyaz S,Javed Z,Attar R,Farooqi AA,Yaylim I,Ahmad A

    更新日期:2019-10-01 00:00:00

  • Carbohydrate antigens on cancer-associated mucin-like molecules.

    abstract::Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-asso...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:

    authors: Ho SB,Kim YS

    更新日期:1991-12-01 00:00:00

  • The microenvironments of multistage carcinogenesis.

    abstract::Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2008.03.019

    authors: Laconi E,Doratiotto S,Vineis P

    更新日期:2008-10-01 00:00:00

  • Requirement for reverse immune surveillance for the growth of germinal center-derived murine lymphomas.

    abstract::The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.2000.0330

    authors: Ponzio NM,Thorbecke GJ

    更新日期:2000-10-01 00:00:00

  • Targeting T cells for GVHD therapy.

    abstract::Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0009

    authors: Vallera DA

    更新日期:1996-04-01 00:00:00

  • Role of natural products in breast cancer related symptomology: Targeting chronic inflammation.

    abstract::Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the qualit...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2020.08.011

    authors: Andrijauskaite K,Wargovich MJ

    更新日期:2020-09-03 00:00:00

  • Nanomedicine in treatment of breast cancer - A challenge to conventional therapy.

    abstract::Amongst the various types of cancer, breast cancer is a highly heterogeneous disease and known as the leading cause of death among women globally. The extensive interdisciplinary investigation in nanotechnology and cancer biomedical research has been evolved over the years for its effective treatment. However, the adv...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2019.12.016

    authors: Afzal M,Ameeduzzafar,Alharbi KS,Alruwaili NK,Al-Abassi FA,Al-Malki AAL,Kazmi I,Kumar V,Kamal MA,Nadeem MS,Aslam M,Anwar F

    更新日期:2019-12-20 00:00:00

  • T antigen transgenic mouse models.

    abstract::The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2009.02.002

    authors: Sáenz Robles MT,Pipas JM

    更新日期:2009-08-01 00:00:00

  • Effect of non-enzymatic glycosylation in the epigenetics of cancer.

    abstract::The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or glycation of cellular proteins result in the generation and accumulation of advanced glycation end products (AGEs) that are associated with the epigenetics of cancer. Epigenetic modifications are inheritable changes without alterations ...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.11.019

    authors: Rehman S,Aatif M,Rafi Z,Khan MY,Shahab U,Ahmad S,Farhan M

    更新日期:2020-12-02 00:00:00

  • Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma.

    abstract::Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1006/scbi.1996.0023

    authors: Niedobitek G,Agathanggelou A,Nicholls JM

    更新日期:1996-08-01 00:00:00

  • Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs.

    abstract::Data obtained from cutting-edge research have shown that deregulated epigenetic marks are critical hallmarks of cancer. Rapidly emerging scientific evidence has helped in developing a proper understanding of the mechanisms leading to control of cellular functions, from changes in chromatin accessibility, transcription...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章

    doi:10.1016/j.semcancer.2020.07.013

    authors: Farooqi AA,Fayyaz S,Poltronieri P,Calin G,Mallardo M

    更新日期:2020-07-30 00:00:00

  • Mitochondrial ribosomes in cancer.

    abstract::Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestig...

    journal_title:Seminars in cancer biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semcancer.2017.04.004

    authors: Kim HJ,Maiti P,Barrientos A

    更新日期:2017-12-01 00:00:00