Growing evidence that several human cancers may originate in utero.

abstract：:Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observ...

journal_title：Seminars in cancer biology

authors： Sloane BF,Yan S,Podgorski I,Linebaugh BE,Cher ML,Mai J,Cavallo-Medved D,Sameni M,Dosescu J,Moin K

更新日期：2005-04-01 00:00:00

abstract：:Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins. ER stress triggers a conserved...

journal_title：Seminars in cancer biology

authors： González-Quiroz M,Urra H,Limia CM,Hetz C

更新日期：2018-06-01 00:00:00

abstract：:The biology and the pathology of the stress-activated protein kinases (SAPKs; p38s and c-Jun-NH(2)-terminal kinases (JNKs)) are somewhat confusing. In some systems, these enzymes augment cell proliferation whereas in other cells they support growth arrest and tumor suppressing activity. Similarly, in some types of can...

journal_title：Seminars in cancer biology

authors： Engelberg D

更新日期：2004-08-01 00:00:00

abstract：:Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

journal_title：Seminars in cancer biology

authors： Lehembre F,Regenass U

更新日期：2012-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried...

journal_title：Seminars in cancer biology

authors： Zeng YX,Jia WH

更新日期：2002-12-01 00:00:00

abstract：:Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation a...

journal_title：Seminars in cancer biology

authors： Huynh J,Etemadi N,Hollande F,Ernst M,Buchert M

更新日期：2017-08-01 00:00:00

abstract：:The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and the host immune system in SjL/J mice. According to reverse immune surveillance, recognition of tumor cell antigens and a response by the host ...

journal_title：Seminars in cancer biology

authors： Ponzio NM,Thorbecke GJ

更新日期：2000-10-01 00:00:00

abstract：:Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the r...

journal_title：Seminars in cancer biology

authors： Mantovani A,Allavena P,Sozzani S,Vecchi A,Locati M,Sica A

更新日期：2004-06-01 00:00:00

abstract：:DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy...

journal_title：Seminars in cancer biology

authors： Skvortsov S,Debbage P,Lukas P,Skvortsova I

更新日期：2015-04-01 00:00:00

abstract：:Proliferating cells and tumor cells in particular express the pyruvate kinase isoenzyme type M2 (M2-PK). Within the tumor metabolome M2-PK regulates the proportions of glucose carbons that are channelled to synthetic processes (inactive dimeric form) or used for glycolytic energy production (highly active tetrameric f...

journal_title：Seminars in cancer biology

authors： Mazurek S,Boschek CB,Hugo F,Eigenbrodt E

更新日期：2005-08-01 00:00:00

abstract：:Over the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against ch...

journal_title：Seminars in cancer biology

authors： Espinoza-Sánchez NA,Götte M

更新日期：2020-05-01 00:00:00

abstract：:Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in cancer related mortality in men in most Western industrialized countries. Androgen and androgen receptor (AR) are the dominant modulators of PCa growth. Over the last two decades multiple advancements in screening, treatment, sur...

journal_title：Seminars in cancer biology

authors： Kallifatidis G,Hoy JJ,Lokeshwar BL

更新日期：2016-10-01 00:00:00

abstract：:In animal models complete and permanent eradication of tumors can be achieved by adoptive transfer of tumor specific T cells, combined with interleukin 2. The most active cells are CD8+ cytotoxic T lymphocytes (CTL), which recognize peptides of 8-10 amino acids in length, bound to the antigen presenting groove of MHC ...

journal_title：Seminars in cancer biology

authors： Melief CJ,Kast WM

更新日期：1991-10-01 00:00:00

abstract：:Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...

journal_title：Seminars in cancer biology

authors： Barker HE,Scott CL

更新日期：2020-04-01 00:00:00

abstract：:The marginal level of clinical responses to the Chloroethylnitrosoureas (CENU, i.e. BCNU, CCNU, MeCCNU) suggests that there may exist an innate mechanism of resistance in tumors to these chemotherapeutic agents. A decade of research from many laboratories around the world has led to the identification of the mechanism...

journal_title：Seminars in cancer biology

authors： Erickson LC

更新日期：1991-08-01 00:00:00

abstract：:T cell acute leukaemias involve a number of different classes of oncogenes. A group of such genes is the RBTN family located on chromosomes 11 and 12. Two members of this family, RBTN1/Ttg-1 and RBTN2/Ttg-2, are located near recurring T cell acute lymphocytic leukaemia-associated translocations. Chromosomal translocat...

journal_title：Seminars in cancer biology

authors： Sánchez-García I,Rabbitts TH

更新日期：1993-12-01 00:00:00

abstract：:Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and...

journal_title：Seminars in cancer biology

authors： Gabriely G,Quintana FJ

更新日期：2020-08-01 00:00:00

abstract：:The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...

journal_title：Seminars in cancer biology

authors： Packham G,Stevenson F

更新日期：2010-12-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are members of zinc-dependent endopeptidases implicated in a variety of physiological and pathological processes. Over the decades, MMPs have been studied for their role in cancer progression, migration, and metastasis. As a result, accumulated evidence of MMPs incriminating role has m...

journal_title：Seminars in cancer biology

authors： Alaseem A,Alhazzani K,Dondapati P,Alobid S,Bishayee A,Rathinavelu A

更新日期：2019-06-01 00:00:00

abstract：:Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of...

journal_title：Seminars in cancer biology

authors： Øra I,Eggert A

更新日期：2011-10-01 00:00:00

abstract：:Cancer cells show various types of mutations and aberrant expression in genes involved in DNA repair responses. These alterations induce genome instability and promote carcinogenesis steps and cancer progression processes. These defects in DNA repair have also been considered as suitable targets for cancer therapies. ...

journal_title：Seminars in cancer biology

authors： Motegi A,Masutani M,Yoshioka KI,Bessho T

更新日期：2019-10-01 00:00:00

abstract：:The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The st...

journal_title：Seminars in cancer biology

authors： Todaro GJ,Rose TM,Spooner CE,Shoyab M,Plowman GD

更新日期：1990-08-01 00:00:00

abstract：:Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current...

journal_title：Seminars in cancer biology

authors： Wu L,Griffin JD

更新日期：2004-10-01 00:00:00

abstract：:Application of nanotechnologies to cancer therapy might increase solubility and/or bioavailability of bioactive compounds of natural or synthetic origin and offers other potential benefits in cancer therapy, including selective targeting. In the present review we aim to evaluate in vivo studies on the anticancer activ...

journal_title：Seminars in cancer biology

authors： Aiello P,Consalvi S,Poce G,Raguzzini A,Toti E,Palmery M,Biava M,Bernardi M,Kamal MA,Perry G,Peluso I

更新日期：2019-08-24 00:00:00

abstract：:Investigations across a range of disciplines over the past decade have brought the study of cell motility and its role in invasion to an exciting threshold. The biophysical forces proximally involved in generating cell locomotion, as well as the underlying signaling and genomic regulatory processes, are gradually beco...

journal_title：Seminars in cancer biology

authors： Kassis J,Lauffenburger DA,Turner T,Wells A

更新日期：2001-04-01 00:00:00

abstract：:The anaphase promoting complex/ cyclosome (APC/C), is an evolutionarily conserved protein complex essential for cellular division due to its role in regulating the mitotic transition from metaphase to anaphase. In this review, we highlight recent work that has shed light on our understanding of the role of APC/C coact...

journal_title：Seminars in cancer biology

authors： Schrock MS,Stromberg BR,Scarberry L,Summers MK

更新日期：2020-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...

journal_title：Seminars in cancer biology

authors： Wang W,Kandimalla R,Huang H,Zhu L,Li Y,Gao F,Goel A,Wang X

更新日期：2019-04-01 00:00:00

abstract：:Macroautophagy (herein autophagy) is an intracellular pathway in which cytoplasmic components are captured by double-membrane vesicles (autophagosomes) that eventually fuse with lysosomes to degrade the cargo. Basal levels of autophagy in all eukaryotic cells maintain cellular homeostasis and under conditions of stres...

journal_title：Seminars in cancer biology

authors： Ammanathan V,Vats S,Abraham IM,Manjithaya R

更新日期：2020-11-01 00:00:00

abstract：:What is the clinical significance of the expression by common human carcinomas of the Thomsen-Friedenreich (TF) antigen? Described as a terminal disaccharide which is a precursor of MN blood group antigens, it was discovered as a laboratory curiosity 60 years ago, yet its cancer-association has only been appreciated i...

journal_title：Seminars in cancer biology

authors： MacLean GD,Longenecker BM

更新日期：1991-12-01 00:00:00

abstract：:Nucleotide sequence analysis at five distinct loci across the 140, 000 bp genomes of more than 60 KSHV samples from KS and PEL tumors from North America, Africa, the Middle East, Asia and the Pacific revealed that they cluster into four major subtypes (A, B, C and D) that have close associations with the geographic an...

journal_title：Seminars in cancer biology

authors： Hayward GS

更新日期：1999-06-01 00:00:00