Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways.

abstract：:Breast cancer is the most common cancer in women worldwide. There have been many advancements in the treatment of breast cancer leading to an increased population of patients living with this disease. Accumulating evidence suggests that cancer diagnosis and aftermath experienced stress could not only affect the qualit...

journal_title：Seminars in cancer biology

authors： Andrijauskaite K,Wargovich MJ

更新日期：2020-09-03 00:00:00

abstract：:The major cause of death from cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second...

journal_title：Seminars in cancer biology

authors： Fidler IJ

更新日期：2002-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs),...

journal_title：Seminars in cancer biology

authors： Min L,He B,Hui L

更新日期：2011-02-01 00:00:00

abstract：:Amino-bisphosphonates (N-BPs) have been commercially available for over four decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of malignancy, and bone metastases derived from various cancer types. Zoledronate and alendronate, two of the most potent N-BPs, have demonstrated direct t...

journal_title：Seminars in cancer biology

authors： La-Beck NM,Liu X,Shmeeda H,Shudde C,Gabizon AA

更新日期：2019-12-23 00:00:00

abstract：:Alterations in the rate and pattern of cell movement are prominent features of many human diseases, including inflammation, cardiovascular disease and cancer. The ability to regulate the interactions of cells with each other and with adhesion factors in extracellular matrices therefore offers a novel approach to the t...

journal_title：Seminars in cancer biology

authors： Humphries MJ

更新日期：1993-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common histological form of primary liver cancer; the tumor cells having retained features of hepatocytic differentiation. It is important to emphasize the heterogeneity of the histological background on which the tumor develops. Most HCCs complicate the evolution of an activ...

journal_title：Seminars in cancer biology

authors： Bréchot C,Gozuacik D,Murakami Y,Paterlini-Bréchot P

更新日期：2000-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise under...

journal_title：Seminars in cancer biology

authors： Wang W,Kandimalla R,Huang H,Zhu L,Li Y,Gao F,Goel A,Wang X

更新日期：2019-04-01 00:00:00

abstract：:Disseminated tumor cells are present in many patients at diagnosis. At a time when the disseminated disease becomes prominent, patients have already been treated with many cycles of therapy to which their metastases were also exposed. These metastases have genetically evolved from primary tumors. Furthermore, their in...

journal_title：Seminars in cancer biology

authors： Lehembre F,Regenass U

更新日期：2012-06-01 00:00:00

abstract：:The cysteine proteinase cathepsin B has been implicated in the progression of tumors from a premalignant to a malignant state. Activity of cathepsin B has been shown to be elevated in parallel with malignancy or metastatic potential of human and rodent tumors. These increases in cathepsin B activity correspond in part...

journal_title：Seminars in cancer biology

authors： Sloane BF

更新日期：1990-04-01 00:00:00

abstract：:Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried ...

journal_title：Seminars in cancer biology

authors： Barker HE,Scott CL

更新日期：2020-04-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...

journal_title：Seminars in cancer biology

authors： Niedobitek G,Agathanggelou A,Nicholls JM

更新日期：1996-08-01 00:00:00

abstract：:Bone marrow transplantation is currently used to treat a variety of life-threatening diseases. Its applications could be expanded if the risks of graft-versus-host disease (GVHD), a complex pathologic disease, could be reduced. Immunotoxins may provide a means to control drug refractory GVHD. This article will discuss...

journal_title：Seminars in cancer biology

authors： Vallera DA

更新日期：1996-04-01 00:00:00

abstract：:Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...

journal_title：Seminars in cancer biology

authors： Gilboa E,Lyerly HK,Vieweg J,Saito S

更新日期：1994-12-01 00:00:00

abstract：:Different types of RNAs identified thus far represent a diverse group of macromolecules that are involved in the regulation of different biological processes. RNA is generally thought to be localized primarily in the nucleus and cytoplasm; however, some types of RNA have been detected in the extracellular milieu. Thes...

journal_title：Seminars in cancer biology

authors： Redzic JS,Balaj L,van der Vos KE,Breakefield XO

更新日期：2014-10-01 00:00:00

abstract：:A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, c...

journal_title：Seminars in cancer biology

authors： O'Neill GM,Stehn J,Gunning PW

更新日期：2008-02-01 00:00:00

abstract：:Hormone-related cancers may originate in utero. Accumulating evidence is given by animal studies, descriptive epidemiologic data and analytic etiologic studies. Indicators of high levels of endogenous pregnancy hormones, like high birth weight and jaundice in the offspring, are associated with increased risk for breas...

journal_title：Seminars in cancer biology

authors： Ekbom A

更新日期：1998-08-01 00:00:00

abstract：:Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting ...

journal_title：Seminars in cancer biology

authors： Braicu C,Mehterov N,Vladimirov B,Sarafian V,Nabavi SM,Atanasov AG,Berindan-Neagoe I

更新日期：2017-10-01 00:00:00

abstract：:The retinoblastoma tumor suppressor gene is inactivated in retinoblastomas and a variety of other tumor types. In addition, it is one of several cellular proteins targeted by the transforming proteins of the small DNA tumor viruses. At least two other cellular proteins that are targeted by the viral transforming prote...

journal_title：Seminars in cancer biology

authors： Whyte P

更新日期：1995-04-01 00:00:00

abstract：:Cancer, being the most prevalent and resistant disease afflicting any gender, age or social status, is the ultimate challenge for the scientific community. The new generation therapeutics for cancer management has shifted the approach to personalized/precision medicine, making use of patient- and tumor-specific marker...

journal_title：Seminars in cancer biology

authors： Zafar S,Beg S,Panda SK,Rahman M,Alharbi KS,Jain GK,Ahmad FJ

更新日期：2019-08-20 00:00:00

abstract：:The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...

journal_title：Seminars in cancer biology

authors： Packham G,Stevenson F

更新日期：2010-12-01 00:00:00

abstract：:Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...

journal_title：Seminars in cancer biology

authors： Vera-Ramirez L

更新日期：2020-02-01 00:00:00

abstract：:Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observ...

journal_title：Seminars in cancer biology

authors： Sloane BF,Yan S,Podgorski I,Linebaugh BE,Cher ML,Mai J,Cavallo-Medved D,Sameni M,Dosescu J,Moin K

更新日期：2005-04-01 00:00:00

abstract：:Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in contrast to the known hurdles of developing new molecular entities, the approach of repurposing has several advantages. Mostly, it is said that it is faster, safer, easier, and cheaper. In the real world, however, there are onl...

journal_title：Seminars in cancer biology

authors： Gonzalez-Fierro A,Dueñas-González A

更新日期：2019-12-23 00:00:00

abstract：:The growth regulatory functions of a family of structurally related polypeptides are mediated through the membrane-bound epidermal growth factor receptor molecule. This ligand family includes epidermal growth factor, transforming growth factor-alpha, amphiregulin, and polypeptides encoded by several poxviruses. The st...

journal_title：Seminars in cancer biology

authors： Todaro GJ,Rose TM,Spooner CE,Shoyab M,Plowman GD

更新日期：1990-08-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, comprising approximately 75% of all kidney tumors. Recent the Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) studies have significantly advanced the molecular characterization of RCC and facilitated the deve...

journal_title：Seminars in cancer biology

authors： Li QK,Pavlovich CP,Zhang H,Kinsinger CR,Chan DW

更新日期：2019-04-01 00:00:00

abstract：:Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors. Cellular "morphinergic" signaling is predominantly targeted to autocrine/paracrine regulatory processes and is reciprocally linked to stimulate...

journal_title：Seminars in cancer biology

authors： Stefano GB,Kream R

更新日期：2008-06-01 00:00:00

abstract：:The molecular cloning of protein phosphatase 2A subunits from Drosophila has provided insights into the role this enzyme plays in developmental processes and in cell cycle regulation. The trimeric holoenzyme containing the catalytic, 65-kDa and 55-kDa regulatory subunits appears to be preferentially expressed in proli...

journal_title：Seminars in cancer biology

authors： Mayer-Jaekel RE,Hemmings BA

更新日期：1995-08-01 00:00:00

abstract：:Cells adhere to one another and/or to matrices that surround them. Regulation of cell-cell (intercellular) and cell-matrix adhesion is tightly controlled in normal cells, however, defects in cell adhesion are common in the majority of human cancers. Multilateral communication among tumor cells with the extracellular m...

journal_title：Seminars in cancer biology

authors： Bourboulia D,Stetler-Stevenson WG

更新日期：2010-06-01 00:00:00

abstract：:Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis...

journal_title：Seminars in cancer biology

authors： Kittler R,Buchholz F

更新日期：2003-08-01 00:00:00

abstract：:Epidemiological studies implicate steroid hormones as important factors in the development of neoplasia, and hormonal manipulation constitutes an important treatment arm in cancer therapy. Recent studies demonstrate a key role for nuclear receptor proteins in the expression of genes encoding the cytochrome P450 enzyme...

journal_title：Seminars in cancer biology

authors： Parker KL,Schimmer BP

更新日期：1994-10-01 00:00:00