Abstract：
:Proliferating cells and tumor cells in particular express the pyruvate kinase isoenzyme type M2 (M2-PK). Within the tumor metabolome M2-PK regulates the proportions of glucose carbons that are channelled to synthetic processes (inactive dimeric form) or used for glycolytic energy production (highly active tetrameric form, a component of the glycolytic enzyme complex). In tumor cells, the dimeric form of M2-PK (Tumor M2-PK) is always predominant. The dimerization is caused by direct interaction of M2-PK with certain oncoproteins. The switch between the tetrameric and dimeric form of M2-PK allows tumor cells to survive in environments with varying oxygen und nutrient supply.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Mazurek S,Boschek CB,Hugo F,Eigenbrodt Edoi
10.1016/j.semcancer.2005.04.009keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
300-8issue
4eissn
1044-579Xissn
1096-3650pii
S1044-579X(05)00026-Xjournal_volume
15pub_type
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journal_title：Seminars in cancer biology
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