Abstract:
:Epigenetic modifications are heritable yet reversible, essential for normal physiological functions and biological development. Aberrant epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation play a crucial role in cancer progression. In cellular reprogramming, irregular epigenomic modulations alter cell signaling pathways and the expression of tumor suppressor genes and oncogenes, resulting in cancer growth and metastasis. Therefore, alteration of epigenetic-status in cancer cells can be used as a potential target for cancer therapy. Several synthetic epigenetic inhibitors (epi-drugs) and natural epigenetic modulatory bioactives (epi-diets) have been shown to have the potential to alter the aberrant epigenetic status and inhibit cancer progression. Further, the use of combinatorial approaches with epigenetic drugs and diets has brought promising outcomes in cancer prevention and therapy. In this article, we have summarized the epigenetic modulatory activities of epi-drugs, epi-diets, and their combination against various cancers. We have also compiled the preclinical and clinical status of these epigenetic modulators in different cancers.
journal_name
Semin Cancer Bioljournal_title
Seminars in cancer biologyauthors
Mondal P,Natesh J,Penta D,Meeran SMdoi
10.1016/j.semcancer.2020.12.006subject
Has Abstractpub_date
2020-12-09 00:00:00eissn
1044-579Xissn
1096-3650pii
S1044-579X(20)30266-2pub_type
杂志文章abstract::Although much of cancer research relies on Nowell's clonal evolution hypothesis as a conceptual framework, large gaps remain in understanding how tumors develop. The multistage skin cancer model in mice provides continuing insight on fundamental aspects of tumor evolution. In this model, mutation of the oncogene Hras ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.06.003
更新日期:2005-12-01 00:00:00
abstract::More than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-s...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.08.026
更新日期:2020-02-01 00:00:00
abstract::The HLA-G gene gives rise to six differently spliced mRNAs. The membrane bound HLA-G1 molecule containing all three extracellular domains presents peptides that follow motif requirements similar to those of classical HLA class I molecules. This isoform is also capable of inhibiting Natural Killer (NK) cells, but is on...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1998.0105
更新日期:1999-02-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is among the most frequently occurring cancers and the leading causes of cancer mortality worldwide. Identification of the signaling pathways regulating liver carcinogenesis is critical in developing novel chemoprevention and targeted therapies. Mitogen-activated protein kinases (MAPKs),...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2010.10.011
更新日期:2011-02-01 00:00:00
abstract::Raf-1 belongs to a family of serine/threonine protein kinases which are highly conserved through evolution in multicellular organisms. Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane t...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1994-08-01 00:00:00
abstract::As stated by Otto Warburg nearly a century ago, cancer is a metabolic disease, a fermentation caused by malfunctioning mitochondria, resulting in increased anabolism and decreased catabolism. Treatment should, therefore, aim at restoring the energy yield. To decrease anabolism, glucose uptake should be reduced (ketoge...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.01.005
更新日期:2017-04-01 00:00:00
abstract::The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2015.09.004
更新日期:2016-02-01 00:00:00
abstract::People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathop...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2004.06.010
更新日期:2004-12-01 00:00:00
abstract::As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compar...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.07.003
更新日期:2017-12-01 00:00:00
abstract::Notch signaling is mediated by cell-cell interactions and is critical for cell fate determination in many species. Recently, a family of mastermind-like (MAML) transcriptional co-activator genes was identified that encode proteins that cooperate with Notch and CSL to activate transcription. Here, we review our current...
journal_title:Seminars in cancer biology
pub_type: 杂志文章
doi:10.1016/j.semcancer.2004.04.014
更新日期:2004-10-01 00:00:00
abstract::The key molecule for normal B cells is the surface Ig (sIg) of the B-cell receptor, which influences cell behaviour, even after neoplastic transformation. During B-cell maturation, sIg accumulates somatic mutations in the Ig variable region (V) genes and tumours retain these patterns, thereby revealing the point of di...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2010.08.004
更新日期:2010-12-01 00:00:00
abstract::Metastasis is the main cause of cancer-related deaths. Disseminated tumor cells (DTCs), which seed metastasis, can remain undetected in a dormant state for decades after treatment of the primary tumor and their persistence is the main cause of late relapse and death in a substantial proportion of cancer patients. Unde...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.07.027
更新日期:2020-02-01 00:00:00
abstract::Laminins are a growing family of alphabetagamma heterotrimeric proteins, commonly found in basement membranes (BMs). These large molecules promote cell adhesion and migration via integrins and other cell-surface receptors. Over 12 laminin isoforms are presently known. The various isoforms have a cell- and tissue-speci...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/S1044-579X(02)00023-8
更新日期:2002-06-01 00:00:00
abstract::Clinical Oncologists have largely ignored the debate over genetic instability in human cancers. It is clear that genetic lesions themselves provide valuable information in the treatment of patients with cancer and those genetic lesions can be exploited successfully as therapeutic targets. Whether the mechanisms result...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2004.09.009
更新日期:2005-02-01 00:00:00
abstract::Cancer-testis antigens (CTAs) are considered as unique and promising cancer biomarkers and targets for cancer therapy. CTAs are multifunctional protein group with specific expression patterns in normal embryonic and adult cells and various types of cancer cells. CTAs are involved in regulating of the basic cellular pr...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2018.08.006
更新日期:2018-12-01 00:00:00
abstract::The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2019.10.002
更新日期:2020-02-01 00:00:00
abstract::Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/s1044-579x(03)00015-4
更新日期:2003-06-01 00:00:00
abstract::Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is larg...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2006.10.008
更新日期:2007-02-01 00:00:00
abstract::Overt neoplasia is often the result of a chronic disease process encompassing an extended segment of the lifespan of any species. A common pathway in the natural history of the disease is the appearance of focal proliferative lesions that are known to act as precursors for cancer development. It is becoming increasing...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2008.03.019
更新日期:2008-10-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is the human tumour showing the most consistent association with Epstein-Barr virus (EBV). The recent detection of EBV in in-situ NPC lesions has shed light on the sequence of events leading to the development of invasive NPC, and will be discussed in the context of what is known about E...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1996.0023
更新日期:1996-08-01 00:00:00
abstract::Extravasation has been described as a rate-limiting step in the process of hematogeneous metastasis formation. Thereby, transendothelial migration of tumor cells consists of a complex series of events involving multiple cell-cell and cell-matrix interactions. 3D-extravasation assays are valuable tools for the identifi...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.06.006
更新日期:2005-10-01 00:00:00
abstract::Diffuse large B cell lymphoma (DLBCL) is the most common form of B cell non-Hodgkin lymphoma worldwide and comprises a heterogeneous group of malignancies that originate from the malignant transformation of germinal center (GC) B cells. Over the past decade, significant improvement has been achieved in our understandi...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2016.08.001
更新日期:2016-08-01 00:00:00
abstract::Rel/NF-kappa B is a ubiquitous transcription factor that consists of multiple polypeptide subunits, and is subject to complex regulatory mechanisms that involve protein-protein interactions, phosphorylation, ubiquitination, proteolytic degradation, and nucleocytoplasmic translocation. The sophisticated control of Rel/...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1006/scbi.1997.0063
更新日期:1997-04-01 00:00:00
abstract::Distant metastasis is the major cause for therapeutic failures in clinical oncology. Active immunotherapy of patients with low tumor burden would not only contribute to further reduction of the remaining tumor burden to subclinical levels, but it would also establish a constant state of immunity, i.e. immunological me...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1994-12-01 00:00:00
abstract::The study of polyomavirus has benefited immensely from two scientific methodologies, cell culture and in vitro studies on one side and the use of transgenic mice as experimental models on the other. Both approaches allowed us to identify cellular products targeted by the viruses, the consequences of these interactions...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2009.02.002
更新日期:2009-08-01 00:00:00
abstract::What is the clinical significance of the expression by common human carcinomas of the Thomsen-Friedenreich (TF) antigen? Described as a terminal disaccharide which is a precursor of MN blood group antigens, it was discovered as a laboratory curiosity 60 years ago, yet its cancer-association has only been appreciated i...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00
abstract::The processes of intraepithelial migration, intraluminal seeding, and field cancerization as models for initiation, spread, and recurrences of urothelial cell carcinoma (UCC) are reviewed in light of recent molecular investigations. The accumulated molecular data on synchronous and metachronous tumors indicate that th...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2006.02.002
更新日期:2007-06-01 00:00:00
abstract::While tumours arise from acquired mutations in oncogenes or tumour-suppressor genes, it is clearly established that cancers are metabolic diseases characterized by metabolic alterations in tumour cells, and also non-tumour cells of the host organism resulting in tumour cachexia and patient weakness. In this review, we...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2017.03.004
更新日期:2017-04-01 00:00:00
abstract::There is sufficient evidence to suggest that tumor growth elicits specific immune responses, including CD8(+) and CD4(+) T cell responses that may delay tumor growth and could potentially be harnessed to eradicate cancer. Nevertheless the frequent outcome of cancer is lethality associated with uncontrolled growth and ...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2005.11.006
更新日期:2006-04-01 00:00:00
abstract::Both the hexosamine biosynthetic pathway (HBP) and the endoplasmic reticulum (ER) are considered sensors for the nutritional state of the cell. The former is a branch of the glucose metabolic pathway that provides donor molecules for glycosylation processes, whereas the second requires co-translational N-glycosylation...
journal_title:Seminars in cancer biology
pub_type: 杂志文章,评审
doi:10.1016/j.semcancer.2015.04.001
更新日期:2015-08-01 00:00:00