解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbohydrate diets with the risk of pancreatic cancer in a US population. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgab006
更新日期:2021-01-22 00:00:00
abstract::An important issue in current oncological research is prevention as well as early detection of cancer. This includes also the difficulty to predict the progression of early or pre-cancerous lesions to invasive cancer. In this context, the characterization and categorization of pre-neoplastic lesions of squamous cell c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa046
更新日期:2020-12-31 00:00:00
abstract::Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa131
更新日期:2020-12-07 00:00:00
abstract::IARC Monographs are globally-recognized assessments of carcinogenicity published by International Agency for Research on Cancer and directed to national authorities as a contribution to public health. Currently, though not constraining the scope of studies examined, Monographs are declared to involve only hazard ident...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa129
更新日期:2020-12-01 00:00:00
abstract::Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa121
更新日期:2020-11-13 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa059
更新日期:2020-11-13 00:00:00
abstract::Multicellular tumor spheroids (MCTSs) constitute a three-dimensional culture system that recapitulates the in vivo tumor microenvironment. Tumor cells cultured as MCTSs present antineoplastic resistance due to the effect of microenvironmental signals acting upon them. In this work, we evaluated the biological function...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa078
更新日期:2020-11-13 00:00:00
abstract::The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa079
更新日期:2020-11-13 00:00:00
abstract::Human Papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) is increasing in prevalence in the United States, as are cases of patients with multiple HPV+OPSCCs (mHPV+OPSCC). mHPV+OPSCCs present a unique opportunity to examine HPV+OPSCC mutation acquisition and evolution. We performed sequenci...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa111
更新日期:2020-10-19 00:00:00
abstract::This commentary celebrates the 40th year of Carcinogenesis, spanning 1980-2020 with a focus on lung cancer. For lung cancer, these 40 years come toward the end of a century of scientific inquiry that began with descriptions of this highly fatal malignancy and that closes with emphasis on molecular processes and genomi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa094
更新日期:2020-10-15 00:00:00
abstract::Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa050
更新日期:2020-10-15 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are regarded as important functional regulators of various biological processes and are also known to be involved in the occurrence and development of human cancers, including breast cancer (BC). In our present study, the RNA expression profiling data for a large cohort of human BC sampl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz197
更新日期:2020-09-24 00:00:00
abstract::Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeep...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz185
更新日期:2020-08-12 00:00:00
abstract::Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa044
更新日期:2020-08-12 00:00:00
abstract::Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz171
更新日期:2020-07-14 00:00:00
abstract::Previous studies demonstrate that the heavy metal cadmium and the metalloid arsenite activate estrogen receptor-alpha in breast cancer cells by forming a high-affinity complex with the ligand-binding domain of the receptor and that environmentally relevant doses of cadmium have estrogen-like activity in vivo. The pres...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz176
更新日期:2020-07-14 00:00:00
abstract::Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa057
更新日期:2020-07-14 00:00:00
abstract::Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through tra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa020
更新日期:2020-07-14 00:00:00
abstract::Gestational trophoblastic diseases (GTD) are group of pregnancy-related tumors characterized by abnormal levels of 'β-hCG' with higher incidence in South-East Asia, especially India. Our laboratory has reported that wild-type BRCA1 transcriptionally regulates β-hCG in triple negative breast cancers (TNBCs). These fact...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz117
更新日期:2020-07-10 00:00:00
abstract::Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz140
更新日期:2020-07-10 00:00:00
abstract::Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa062
更新日期:2020-07-04 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz123
更新日期:2020-06-17 00:00:00
abstract::Oncogenic pathogens can disturb tissue homeostasis and initiate immune responses for oncogenicity clearance and homeostasis restoration, while failed clearance and chronic inflammation may result in tumorigenesis. The primary tumor development will undergo a cancer immunoediting process, including three phases, termed...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa058
更新日期:2020-06-12 00:00:00
abstract::In hepatocellular carcinoma (HCC), a subset of cells defined by high CD44 and CD133 expression has been reported to possess cancer stem-like cell (CSC) characteristics and to be associated with a poor prognosis. Since the approval of the multi-kinase inhibitor, lenvatinib, for patients with unresectable HCC, two such ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa049
更新日期:2020-05-25 00:00:00
abstract::The hepatitis B virus X protein (HBx) has pleiotropic biological effects, which underlies its potential role in cell transformation. However, its involvement in hepatic fibrosis remains unclear. In this study, we wanted to clarify, in vivo, the role of HBx protein in the development of liver fibrosis. Mice transgenic ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz109
更新日期:2020-05-14 00:00:00
abstract::The phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway is important in the regulation of cell proliferation through its production of phosphatidylinositol 3,4,5-triphosphate (PIP3). Activation of this pathway is frequently observed in human cancers, including non-small cell lung carcinoma. The PI3-K/Akt pathway i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz113
更新日期:2020-05-14 00:00:00
abstract::Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that molecularly and phenotypically resembles human TNBC to study the effects of exo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz172
更新日期:2020-05-14 00:00:00
abstract::Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. I...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz132
更新日期:2020-04-22 00:00:00
abstract::Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs) derived from BM mesenchymal stem cells (MSCs) of MM patients promote the malignant traits via modulation of translation initiation (TI), whereas MVs from normal donors ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz169
更新日期:2020-03-13 00:00:00
abstract::An accurate biomarker or method for diagnosis of thyroid nodule with indeterminate fine-needle aspiration result is essential for clinical treatment. Micro RNAs (miRNAs) of exosomes are advantageous in the diagnosis of tumors because they are highly stable, and be protected by a bilayer membrane structure. Exosomes we...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz160
更新日期:2020-03-13 00:00:00
abstract::Intratumor heterogeneity (ITH) plays an important role in tumor development, metastases, recurrence and has impact on clinical diagnosis, therapeutic responses. In this study, we used mutant-allele tumor heterogeneity (MATH) through whole-exome sequencing data to evaluate ITH in early stage diffuse large B-cell lympho...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz068
更新日期:2019-11-25 00:00:00
abstract::Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz023
更新日期:2019-10-16 00:00:00
abstract::In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz045
更新日期:2019-08-22 00:00:00
abstract::Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and e...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgz072
更新日期:2019-07-06 00:00:00
abstract::The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhibited the oncogenic effects of transforming growth factor-β (TGF-β) i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy178
更新日期:2019-07-06 00:00:00
abstract::Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy132
更新日期:2019-07-04 00:00:00
abstract::Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz026
更新日期:2019-06-10 00:00:00
abstract::Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of TIPE1 is observed in cervical cancer cell lines and tissues, indicating it might exert a distinctive role in cervical cancer. Cell and xenograft tumorigenicity assays showed that TIPE...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy163
更新日期:2019-06-10 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy146
更新日期:2019-05-14 00:00:00
abstract::Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz003
更新日期:2019-05-14 00:00:00