lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells.

abstract：:Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as...

journal_title：Carcinogenesis

authors： Kim DJ,Lee MH,Liu K,Lim DY,Roh E,Chen H,Kim SH,Shim JH,Kim MO,Li W,Ma F,Fredimoses M,Bode AM,Dong Z

更新日期：2017-10-26 00:00:00

abstract：:Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...

journal_title：Carcinogenesis

authors： Steck SE,Gaudet MM,Britton JA,Teitelbaum SL,Terry MB,Neugut AI,Santella RM,Gammon MD

更新日期：2007-09-01 00:00:00

abstract：:Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats are resistant to hepatocar...

journal_title：Carcinogenesis

authors： Wood GA,Korkola JE,Lee VM,Sarma DS,Archer MC

更新日期：1997-09-01 00:00:00

abstract：:A 32P-postlabeling assay was employed for detection and quantitation of DNA adducts formed with carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) activated by a peroxidase system. Enrichment of adducts by digestion with nuclease P1 or by extraction into n-butanol prior to 32P-labeling was used...

journal_title：Carcinogenesis

authors： Stiborová M,Frei E,Schmeiser HH,Wiessler M

更新日期：1992-07-01 00:00:00

abstract：:The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...

journal_title：Carcinogenesis

authors： Diamond L,Kruszewski F,Aden DP,Knowles BB,Baird WM

更新日期：1980-01-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:Reduced DNA repair capacity of carcinogen-induced DNA damage is now thought to significantly influence inherent susceptibility to lung cancer. DNA-dependent protein kinase (DNA-PK) is a serine-threonine kinase activated by the presence of double-strand breaks in DNA that appears to play a major role in non-homologous ...

journal_title：Carcinogenesis

authors： Auckley DH,Crowell RE,Heaphy ER,Stidley CA,Lechner JF,Gilliland FD,Belinsky SA

更新日期：2001-05-01 00:00:00

abstract：:The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...

journal_title：Carcinogenesis

authors： Thompson HJ,McGinley J,Rothhammer K,Singh M

更新日期：1998-03-01 00:00:00

abstract：:Elevated Bcl-xL expression in cancer cells contributes to doxorubicin (DOX) resistance, leading to failure in chemotherapy. In addition, the clinical use of high-dose doxorubicin (DOX) in cancer therapy has been limited by issues with cardiotoxicity and hepatotoxicity. Here, we show that co-treatment with pyrrolidine ...

journal_title：Carcinogenesis

authors： Park SS,Lee DM,Lim JH,Lee D,Park SJ,Kim HM,Sohn S,Yoon G,Eom YW,Jeong SY,Choi EK,Choi KS

更新日期：2018-03-08 00:00:00

abstract：:Lack of functional telomeres can cause chromosomal aberrations. This type of genetic instability may promote tumorigenesis. We have investigated the association between mean telomere length in buccal cells (assessed with quantitative real-time PCR) and bladder cancer risk in a case-control study. Patients with bladder...

journal_title：Carcinogenesis

authors： Broberg K,Björk J,Paulsson K,Höglund M,Albin M

更新日期：2005-07-01 00:00:00

abstract：:We examined allelic loss in colon tumors induced by 1,2-dimethylhydrazine (DMH) in F1 hybrid mice, using sequence-tagged microsatellite site (STMS) primers derived from the chromosomal region closely linked to the p53 locus. Polymerase chain reaction--single-strand conformation polymorphism (PCR-SSCP) analysis of 155 ...

journal_title：Carcinogenesis

authors： Okamoto M,Ohtsu H,Miyaki M,Yonekawa H

更新日期：1993-07-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...

journal_title：Carcinogenesis

authors： Izzotti A,Larghero P,Cartiglia C,Longobardi M,Pfeffer U,Steele VE,De Flora S

更新日期：2010-05-01 00:00:00

abstract：:Previous studies have indicated that the Nb rat has a higher predisposition to the spontaneous development of nephroblastoma than most other strains of laboratory rat. In order to determine whether this inherent susceptibility could be exploited as a model for Wilms' tumor, Nb rats were treated with various chemicals ...

journal_title：Carcinogenesis

authors： Hard GC

更新日期：1985-11-01 00:00:00

abstract：:Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...

journal_title：Carcinogenesis

authors： Chen H,Kluz T,Zhang R,Costa M

更新日期：2010-12-01 00:00:00

abstract：:Tuberin (protein encodes by tuberous sclerosis complex 2, Tsc2) deficiency is associated with the decrease in the DNA repair enzyme 8-oxoG-DNA glycosylase (OGG1) in tumour kidney of tuberous sclerosis complex (TSC) patients. The purpose of this study was to elucidate the mechanisms by which tuberin regulates OGG1. The...

journal_title：Carcinogenesis

authors： Habib SL,Bhandari BK,Sadek N,Abboud-Werner SL,Abboud HE

更新日期：2010-11-01 00:00:00

abstract：:CXCL5 is a member of the CXC-type chemokine family that may play a role in carcinogenesis and cancer progression. This study investigates the biological function and clinical significance of CXCL5 in intrahepatic cholangiocarcinoma (ICC). We demonstrated that CXCL5 was overexpressed in ICC cell lines and tumor samples...

journal_title：Carcinogenesis

authors： Zhou SL,Dai Z,Zhou ZJ,Chen Q,Wang Z,Xiao YS,Hu ZQ,Huang XY,Yang GH,Shi YH,Qiu SJ,Fan J,Zhou J

更新日期：2014-03-01 00:00:00

abstract：:A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...

journal_title：Carcinogenesis

authors： Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

更新日期：1995-08-01 00:00:00

abstract：:Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...

journal_title：Carcinogenesis

authors： Yang H,Fang J,Jia X,Han C,Chen X,Yang CS,Li N

更新日期：2011-03-01 00:00:00

abstract：:The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...

journal_title：Carcinogenesis

authors： Eltom SE,Larsen MC,Jefcoate CR

更新日期：1998-08-01 00:00:00

abstract：:Several studies have indicated a correlation between the presence of inflammation and the development of cancer. The aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-diol), to an ultimate carcin...

journal_title：Carcinogenesis

authors： Petruska JM,Mosebrook DR,Jakab GJ,Trush MA

更新日期：1992-07-01 00:00:00

abstract：:The dorsal skins of 6-8 week old female SENCAR mice were initiated with a single application of 10 nmol of 7,12-dimethylbenz[a]anthracene (DMBA) and subsequently promoted twice/week with topical applications of vitamin E (dl-alpha-tocopherol, 80 mumol/treatment). Vitamin E from two separate commercial suppliers was te...

journal_title：Carcinogenesis

authors： Mitchel RE,McCann R

更新日期：1993-04-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (MT)-proficient Chinese hamster ovary cells were grown in the presence of low, gradually increasing levels of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with the aim of selecting MNNG-resistant cell lines. Six resistant clones with two levels of resistance were isolated. A 3-fol...

journal_title：Carcinogenesis

authors： Aquilina G,Frosina G,Zijno A,Di Muccio A,Dogliotti E,Abbondandolo A,Bignami M

更新日期：1988-07-01 00:00:00

abstract：:Effects of estrogens on the cytoplasmic microtubule network were examined by the indirect immunofluorescence method using anti-beta-tubulin antibody. Estradiol, a naturally occurring estrogen, decreased the amount of cytoplasmic microtubule fibers during interphase in the human breast cancer cell lines MCF-7 and MDA-M...

journal_title：Carcinogenesis

authors： Aizu-Yokota E,Ichinoseki K,Sato Y

更新日期：1994-09-01 00:00:00

abstract：:Chemopreventive agents are compounds that inhibit carcinogenesis when administered prior or subsequent to a course of carcinogen administration. The effects of dietary administration of crocin dyes on the hepatic damage induced by aflatoxin B1 (AFB1) and dimethylnitrosamine (DMN) in rats were investigated. Female Spra...

journal_title：Carcinogenesis

authors： Lin JK,Wang CJ

更新日期：1986-04-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00

abstract：:In hepatocellular carcinoma (HCC), a subset of cells defined by high CD44 and CD133 expression has been reported to possess cancer stem-like cell (CSC) characteristics and to be associated with a poor prognosis. Since the approval of the multi-kinase inhibitor, lenvatinib, for patients with unresectable HCC, two such ...

journal_title：Carcinogenesis

authors： Shigesawa T,Maehara O,Suda G,Natsuizaka M,Kimura M,Shimazaki T,Yamamoto K,Yamada R,Kitagataya T,Nakamura A,Suzuki K,Ohara M,Kawagishi N,Umemura M,Nakai M,Sho T,Morikawa K,Ogawa K,Ohnishi S,Sugiyama M,Mizokami M,

更新日期：2020-05-25 00:00:00

abstract：:A number of model systems have been developed to study the initiating and promoting phases of neoplastic development in rats liver. Four of these protocols use diethylnitrosamine (DEN) initiation, but employ different methods of promotion. The present studies were designed to evaluate these systems under standardized ...

journal_title：Carcinogenesis

authors： Leonard TB,Dent JG,Graichen ME,Lyght O,Popp JA

更新日期：1982-01-01 00:00:00

abstract：:In a previous study a high first-pass metabolism of N-nitrosodi-[1-14C]amylamine (NDAA, 0.59-350 microM) has been shown in isolated perfused rat small intestinal segments. In the present work the identification of metabolites in samples of perfusate and absorbed fluid (absorbate) is reported. After HPLC enrichment and...

journal_title：Carcinogenesis

authors： Richter E,Lorck C,Wiessler M

更新日期：1988-03-01 00:00:00