Differential renal tumor response to N-ethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma.

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00

abstract：:Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...

journal_title：Carcinogenesis

authors： Yuspa SH,Ben T,Hennings H

更新日期：1983-11-01 00:00:00

abstract：:Cancer is a genetic disease in which the interplay between alterations in protein-coding genes and non-coding RNAs (ncRNAs) plays a fundamental role. In recent years, the full coding component of the human genome was sequenced in various cancers, whereas such attempts related to ncRNAs are still fragmentary. We screen...

journal_title：Carcinogenesis

authors： Wojcik SE,Rossi S,Shimizu M,Nicoloso MS,Cimmino A,Alder H,Herlea V,Rassenti LZ,Rai KR,Kipps TJ,Keating MJ,Croce CM,Calin GA

更新日期：2010-02-01 00:00:00

abstract：:Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aroma...

journal_title：Carcinogenesis

authors： Hix C,Oglesby L,MacNair P,Sieg M,Langenbach R

更新日期：1983-11-01 00:00:00

abstract：:A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigen...

journal_title：Carcinogenesis

authors： Yamamoto S,Aizu E,Jiang H,Nakadate T,Kiyoto I,Wang JC,Kato R

更新日期：1991-02-01 00:00:00

abstract：:Specific repair endonucleases were used to quantify oxidative modifications in mitochondrial DNA (mtDNA) from rat liver and from porcine liver and kidney by means of a relaxation assay. In rat liver mitochondria the number of modifications sensitive to formamidopyrimidine--DNA glycosylase (FPG protein), which include ...

journal_title：Carcinogenesis

authors： Hegler J,Bittner D,Boiteux S,Epe B

更新日期：1993-11-01 00:00:00

abstract：:This study analyzes the mechanism by which the tumor promoter 12-0-tetradecanoyl-phorbol 13-acetate (TPA) inhibits binding of epidermal growth factor (EGF) to its membrane receptors in HeLa cells. Kinetic studies indicate that inhibition of EGF binding occurs within a few minutes after exposure of cells to TPA; delaye...

journal_title：Carcinogenesis

authors： Lee LS,Weinstein IB

更新日期：1980-08-01 00:00:00

abstract：:A three-dimensional molecular template has been generated for substrates of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6). This template defines the stereochemical requirements for CYP2D6 substrates in terms of the volume occupied and positions of key atoms. The modelling was based on the X-ray crystallogr...

journal_title：Carcinogenesis

authors： Islam SA,Wolf CR,Lennard MS,Sternberg MJ

更新日期：1991-12-01 00:00:00

abstract：:The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...

journal_title：Carcinogenesis

authors： Bratton MR,Frigo DE,Vigh-Conrad KA,Fan D,Wadsworth S,McLachlan JA,Burow ME

更新日期：2009-01-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) was administered i.p. to male Wistar rats 17 h after partial hepatectomy. Hepatocytes were analyzed for the presence of micronuclei 7 h, 1, 2, 3 and 4 days after injection. N-OH-AAF treatment resulted in a high frequency of micronucleated hepatocytes at days 3 and 4 (19.5% an...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Mulder GJ,Meerman JH

更新日期：1989-04-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:Phenobarbital (PB) is a potent tumor promoter in rodent liver. In this study we investigated whether PB selectively promotes a population of initiated cells with reduced levels of transforming growth factor-beta (TGF beta) receptors types I, II and III. Liver tumors were induced in male Fischer F344 rats by diethylnit...

journal_title：Carcinogenesis

authors： Mansbach JM,Mills JJ,Boyer IJ,De Souza AT,Hankins GR,Jirtle RL

更新日期：1996-01-01 00:00:00

abstract：:The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...

journal_title：Carcinogenesis

authors： Jungert K,Buck A,Buchholz M,Wagner M,Adler G,Gress TM,Ellenrieder V

更新日期：2006-12-01 00:00:00

abstract：:3,3-[3H]Dimethyl-1-phenyltriazene, 1-(4-chlorophenyl)-3,3-[3H]dimethyltriazene and 3,3-[3H]dimethyl-1-(2,4,6-trichlorophenyl)-triazene methylate initiator tRNA in vitro only after pre-incubation with microsomal enzymes and NADPH. The finding confirms that procarcinogenic dialkyl aryltriazenes must be enzymatically con...

journal_title：Carcinogenesis

authors： Hradec J,Kolar GF

更新日期：1985-07-01 00:00:00

abstract：:In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg p...

journal_title：Carcinogenesis

authors： Zhao J,Lahiri-Chatterjee M,Sharma Y,Agarwal R

更新日期：2000-04-01 00:00:00

abstract：:In order to explore a possibility that the custom of drinking green tea infusion is efficacious for reducing the carcinogenic risk of environmental exposure to pentachlorophenol (PCP), we examined the effects in a hepato- and cholangiocarcinogenesis model in mice exposed to diethylnitrosamine (DEN). In the first exper...

journal_title：Carcinogenesis

authors： Umemura T,Kai S,Hasegawa R,Kanki K,Kitamura Y,Nishikawa A,Hirose M

更新日期：2003-06-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:In this study, our goal was to identify genes whose expression in liver is altered in female F-344 rats during mitosuppression induced by 42 days of ethinyl estradiol (EE) treatment (Yager et al., Carcinogenesis, 15, 2117-2123, 1994). Northern analysis demonstrated that the mRNA levels for transforming growth factor-b...

journal_title：Carcinogenesis

authors： Chen J,Schwartz DA,Young TA,Norris JS,Yager JD

更新日期：1996-12-01 00:00:00

abstract：:Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets...

journal_title：Carcinogenesis

authors： Ding JL,Hee PL,Lam TJ

更新日期：1989-03-01 00:00:00

abstract：:We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first positi...

journal_title：Carcinogenesis

authors： Kamiya H,Murata-Kamiya N,Koizume S,Inoue H,Nishimura S,Ohtsuka E

更新日期：1995-04-01 00:00:00

abstract：:Yeasts were isolated from 12 cases of oral precancerous lesions (leukoplakia and erythroleukoplakia) by sampling the lesion as well as normal mucosa of each patient, yielding 21 strains of Candida albicans belonging to 15 biotypes, two strains of C. tropicalis, one strain of C. parapsilosis and two strains of Torulops...

journal_title：Carcinogenesis

authors： Krogh P,Hald B,Holmstrup P

更新日期：1987-10-01 00:00:00

abstract：:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...

journal_title：Carcinogenesis

authors： Stitzel KA,Horn PA,Ezra MF

更新日期：1990-12-01 00:00:00

abstract：:p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53. In this study, we investigated the role and mechanism of PUMA induction in response to serum starvation in p53-deficient cancer cells. Following serum ...

journal_title：Carcinogenesis

authors： Ming L,Sakaida T,Yue W,Jha A,Zhang L,Yu J

更新日期：2008-10-01 00:00:00

abstract：:The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I (AAI) and aristolochic acid II (AAII), was investigated. Under anaerobic conditions the major metabolites were the corresponding aristolactams for both AAI and AAII. In contrast under aerob...

journal_title：Carcinogenesis

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical dialkylnitrosamines with 2-5 carbon atoms per side chai...

journal_title：Carcinogenesis

authors： Richter E,Richter-Cooberg U,Feng X,Schulze J,Wiessler M

更新日期：1986-07-01 00:00:00

abstract：:As renal cell carcinomas are characterized by the disappearance of the transcription factor LFB1, which is known to be primarily involved in gene regulation in the liver, we have measured the presence of LFB1 in rat hepatocellular carcinomas induced by diethylnitrosamine. The level of LFB1 binding activity in adenoid-...

journal_title：Carcinogenesis

authors： Stumpf H,Senkel S,Rabes HM,Ryffel GU

更新日期：1995-01-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a mutagen found in cooked meat, has been shown to induce mammary gland tumors in rats. Our laboratory recently observed that a high fat diet enhances the incidence and severity of PhIP-induced mammary gland cancer in rats. In the current study, reverse transcript...

journal_title：Carcinogenesis

authors： Davis CD,Snyderwine EG

更新日期：1995-12-01 00:00:00

abstract：:Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...

journal_title：Carcinogenesis

authors： de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

更新日期：2005-11-01 00:00:00

abstract：:The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...

journal_title：Carcinogenesis

authors： Cooper CS,Pal K,Hewer A,Grover PL,Sims P

更新日期：1982-01-01 00:00:00