Expression of the glutathione S-transferase placental form in human lung carcinomas.


:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly differentiated adenocarcinomas were, however, negatively stained (0/5 cases), while moderately and well differentiated adenocarcinomas were found to stain with GST-pi at rates of 69% (9/13 cases) and 71% (5/7 cases), respectively. Six cases of small cell carcinomas examined were all negative. The results indicate that GST-pi may be a useful marker for non-small cell type lung cancer, especially squamous cell carcinoma which is in agreement with findings for rat lung neoplastic lesions reported previously.






Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y




Has Abstract


1988-12-01 00:00:00












  • Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice.

    abstract::1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...


    pub_type: 杂志文章


    authors: Csanády GA,Guengerich FP,Bond JA

    更新日期:1992-07-01 00:00:00

  • miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF.

    abstract::Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a and miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2, have been implicated in cell cycle, apoptosis and proliferation. In this study, we investigated the possible role ...


    pub_type: 杂志文章


    authors: Sun CY,She XM,Qin Y,Chu ZB,Chen L,Ai LS,Zhang L,Hu Y

    更新日期:2013-02-01 00:00:00

  • Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells.

    abstract::The development of human breast cancer is a complex multi-step process that depends on various exogenous and endogenous factors that modulate the transformation of normal human breast epithelial cells into neoplastic ones. Using a spontaneously-immortalized human breast epithelial (MCF-10F) cell line, we have shown pr...


    pub_type: 杂志文章


    authors: Roy D,Calaf G,Hei TK

    更新日期:2001-10-01 00:00:00

  • Marmoset CYP1A2: primary structure and constitutive expression in livers.

    abstract::Complementary DNA of marmoset CYP1A2 was isolated by means of screening the cDNA library and reverse-transcriptase polymerase chain reaction. The deduced amino acid sequence of marmoset CYP1A2 consisted of 516 residues and showed 88.2 and 90.0% identities to corresponding forms in human and cynomolgus monkey, respecti...


    pub_type: 杂志文章


    authors: Sakuma T,Igarashi T,Hieda M,Ohgiya S,Isogai M,Ninomiya S,Nagata R,Nemoto N,Kamataki T

    更新日期:1997-10-01 00:00:00

  • Low-carbohydrate diets and the risk of pancreatic cancer: a large prospective cohort study.

    abstract::Low-carbohydrate diets have become a popular approach for weight loss in recent years. However, whether low-carbohydrate diets are associated with the risk of pancreatic cancer remains to be elucidated. Hence, we examined the association of low-carbohydrate diets with the risk of pancreatic cancer in a US population. ...


    pub_type: 杂志文章


    authors: Zhong GC,Li QJ,Yang PF,Wang YB,Hao FB,Wang K,Hu JJ,Wu JJ

    更新日期:2021-01-22 00:00:00

  • Dose-related differences in DNA adduct levels in rodent tissues following skin application of complex mixtures from air pollution sources.

    abstract::Dose-related differences in the binding of DNA reactive intermediates for three environmentally important complex mixture particulate extracts and a well-studied carcinogen, benzo[a]pyrene (BaP), were examined in female C-57 mice following multiple topical treatments ranging from 1 to 120 mg/mouse. Particulate extract...


    pub_type: 杂志文章


    authors: Gallagher JE,Jackson MA,George MH,Lewtas J

    更新日期:1990-01-01 00:00:00

  • Catalysis of nitrosation in vitro and in vivo in rats by catechin and resorcinol and inhibition by chlorogenic acid.

    abstract::Measurements were made of the effects of phenolic compounds, some of which are present in the human diet, on the nitrosation of proline by nitrite to give N-nitrosoproline (NPRO). In vitro, resorcinol, catechin, p-nitrosophenol and phenol were catalysts and chlorogenic acid an inhibitor; guaiacol showed a marginal cat...


    pub_type: 杂志文章


    authors: Pignatelli B,Bereziat JC,Descotes G,Bartsch H

    更新日期:1982-01-01 00:00:00

  • Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens.

    abstract::Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytos...


    pub_type: 杂志文章


    authors: Rice JC,Ozcelik H,Maxeiner P,Andrulis I,Futscher BW

    更新日期:2000-09-01 00:00:00

  • Skin carcinogenesis and promoter binding characteristics in different mouse strains.

    abstract::The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...


    pub_type: 杂志文章


    authors: Wheldrake JF,Marshall J,Ramli J,Murray AW

    更新日期:1982-01-01 00:00:00

  • Candida albicans as a promoter of oral mucosal neoplasia.

    abstract::A model of oral mucosal carcinogenesis using the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was combined with a model of oral mucosal candidosis to examine the ability of Candida albicans to promote the development of neoplasia in suitably initiated epithelium. Sprague-Dawley rats were initiated by the a...


    pub_type: 杂志文章


    authors: O'Grady JF,Reade PC

    更新日期:1992-05-01 00:00:00

  • Restoration of preferential and strand specific gene repair in group 2 Chinese hamster ovary mutants (UV5) by the XPD (ERCC2) gene.

    abstract::It has recently been reported that the XPD (ERCC2) gene is an integral component of the basal transcription factor TFIIH. We have studied the direct role of this repair gene on the fine structure of DNA repair in hamster cells. The gene and strand specific DNA repair of UV induced pyrimidine dimers was determined in w...


    pub_type: 杂志文章


    authors: Cullinane C,Weber CA,Dianov G,Bohr VA

    更新日期:1997-04-01 00:00:00

  • Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.

    abstract::Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...


    pub_type: 杂志文章


    authors: Loprinzi CL,Verma AK

    更新日期:1985-11-01 00:00:00

  • Partial persistency of 2-aminofluorene and N-acetyl-2-aminofluorene in rat liver DNA.

    abstract::Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...


    pub_type: 杂志文章


    authors: Visser A,Westra JG

    更新日期:1981-01-01 00:00:00

  • Human melanomas of fibroblast and epithelial morphology differ widely in their ability to synthesize retinyl esters.

    abstract::Reduced retinyl ester synthesis has been associated with several forms of cancer; we therefore proposed studying melanoma development from the perspective of this biochemical pathway. Cultures of human melanoma cells with fibroblastoid morphology showed negligible retinyl ester synthesis; in sharp contrast, those with...


    pub_type: 杂志文章


    authors: Simmons DP,Andreola F,De Luca LM

    更新日期:2002-11-01 00:00:00

  • Cell cross-talk mediates PPARalpha null hepatocyte proliferation after peroxisome proliferator exposure.

    abstract::Peroxisome proliferator activated receptor(alpha) (PPARalpha) mediates the liver's responses to peroxisome proliferator compounds. These responses include induction of specific hepatic enzymes, peroxisome proliferation and hepatocyte proliferation. PPARalpha null mice, which lack receptor in all cells of the body, do ...


    pub_type: 杂志文章


    authors: Weglarz TC,Sandgren EP

    更新日期:2004-01-01 00:00:00

  • Induction of DNA repair synthesis in human monocytes/B-lymphocytes compared with T-lymphocytes after exposure to N-acetoxy-N-acetylaminofluorene and dimethylsulfate in vitro.

    abstract::We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...


    pub_type: 杂志文章


    authors: Knudsen LE,Ryder LP,Wassermann K

    更新日期:1992-07-01 00:00:00

  • Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains.

    abstract::The aim of the present study was to investigate the impact of four different lactobacillus (LB) strains, namely Lactobacillus bulgaricus 291, Streptococcus thermophilus F4, S.thermophilus V3 and Bifidobacterium longum BB536, which are used for the production of yogurt, on the DNA-damaging effects of heterocyclic aroma...


    pub_type: 杂志文章


    authors: Zsivkovits M,Fekadu K,Sontag G,Nabinger U,Huber WW,Kundi M,Chakraborty A,Foissy H,Knasmüller S

    更新日期:2003-12-01 00:00:00

  • Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis.

    abstract::The role of urinary pH and Na+ concentration on the bladder carcinogenesis of o-phenylphenol (OPP) was examined in male F344 rats. The rats were given powdered diet containing 2% sodium o-phenylphenate (OPP-Na, group 1), 1.25% OPP plus 0.64% NaHCO3 (group 2), 1.25% OPP plus 0.32% NaHCO3 (group 3), 1.25% OPP plus 0.16%...


    pub_type: 杂志文章


    authors: Fukushima S,Inoue T,Uwagawa S,Shibata MA,Ito N

    更新日期:1989-09-01 00:00:00

  • Induction of free radicals and tumors in the kidneys of Wistar rats by ferric ethylenediamine-N,N'-diacetate.

    abstract::An iron chelate, ferric ethylenediamine-N,N'-diacetate [Fe(III)-EDDA], was found to produce hydroxyl radicals with hydrogen peroxide, as determined by both a deoxyribose degradation test and electron spin resonance. Hydroxyl radical production was inhibited not only by adding hydroxyl radical scavengers and catalase, ...


    pub_type: 杂志文章


    authors: Liu M,Okada S

    更新日期:1994-12-01 00:00:00

  • Bovine bladder and liver cell and homogenate-mediated mutagenesis of Salmonella typhimurium with aromatic amines.

    abstract::Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aroma...


    pub_type: 杂志文章


    authors: Hix C,Oglesby L,MacNair P,Sieg M,Langenbach R

    更新日期:1983-11-01 00:00:00

  • Solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine.

    abstract::Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...


    pub_type: 杂志文章


    authors: Smith CA,Xu YZ,Swann PF

    更新日期:1990-05-01 00:00:00

  • Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.

    abstract::The cyclooxygenase-2 (COX-2) inhibitor celecoxib and the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO) were each previously shown to prevent skin tumor development when administered throughout the course of UV irradiation. This raised the question of whether maintenance or continued growth of ...


    pub_type: 杂志文章


    authors: Fischer SM,Conti CJ,Viner J,Aldaz CM,Lubet RA

    更新日期:2003-05-01 00:00:00

  • Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat.

    abstract::The Tsc-2 tumor suppressor gene encodes the protein tuberin, a multi-functional protein with sequence homology to the GTPase activating protein (GAP) for Rap1. Mutations in the Tsc-2 gene are associated with the development of renal tumors. The Eker rat (Tsc-2(EK/+)) bears a mutation in one allele of the Tsc-2 gene, w...


    pub_type: 杂志文章


    authors: Habib SL,Phan MN,Patel SK,Li D,Monks TJ,Lau SS

    更新日期:2003-03-01 00:00:00

  • DNA adduct formation by allyl glycidyl ether.

    abstract::Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...


    pub_type: 杂志文章


    authors: Plna K,Segerbäck D,Schweda EK

    更新日期:1996-07-01 00:00:00

  • Age-dependent odontogenic lesions in rats after a single i.p. injection of N-nitroso-N-methylurea.

    abstract::The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/-...


    pub_type: 杂志文章


    authors: Smulow JB,Konstantinidis A,Sonnenschein C

    更新日期:1983-09-01 00:00:00

  • Effect of chemical carcinogens on cholesterol biosynthetic pathways in the skin of mice.

    abstract::The metabolism of zymosterol and mevalonic acid was studied in vitro using the skin homogenates of 3-methylcholanthrene (3MC), diazacholesterol-treated and untreated mice. In normal mouse skin only lathosterol was a major metabolite and the other metabolites, cholesta-5,7,24-trien-3 beta-ol, desmosterol, cholesterol a...


    pub_type: 杂志文章


    authors: Tanimoto Y,Fukao K,Yoshiga K,Takada K,Ohyama Y,Okuda K

    更新日期:1990-09-01 00:00:00

  • Benzoyl peroxide promotes the formation of melanotic tumors in the skin of 7,12-dimethylbenz[a]anthracene-initiated Syrian golden hamsters.

    abstract::A two-stage carcinogenesis experiment was performed in Syrian golden hamsters using a single intragastric initiation with 10 mg/kg body weight of 7,12-dimethylbenz[a]anthracene (DMBA) and repetitive topical promotion on the back skin with two different doses (80 and 160 mg, respectively) of benzoyl peroxide in 1 ml ac...


    pub_type: 杂志文章


    authors: Schweizer J,Loehrke H,Edler L,Goerttler K

    更新日期:1987-03-01 00:00:00

  • Transplacental genotoxicity of diethylstilbestrol.

    abstract::Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day...


    pub_type: 杂志文章


    authors: Gladek A,Liehr JG

    更新日期:1991-05-01 00:00:00

  • Dose-response studies of MeIQx in rat liver and liver DNA at low doses.

    abstract::2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...


    pub_type: 杂志文章


    authors: Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

    更新日期:1995-02-01 00:00:00

  • Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates.

    abstract::Macrophages and their immortalized cell lines can be activated to form nitrite and nitrate via oxidation of arginine and this is accompanied by the formation of N-nitroso compounds. The mechanism of nitrosamine formation has been investigated through the use of compounds which are known either to inhibit or enhance ac...


    pub_type: 杂志文章


    authors: Kosaka H,Wishnok JS,Miwa M,Leaf CD,Tannenbaum SR

    更新日期:1989-03-01 00:00:00