Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.

abstract：:Several studies have indicated a correlation between the presence of inflammation and the development of cancer. The aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-diol), to an ultimate carcin...

journal_title：Carcinogenesis

authors： Petruska JM,Mosebrook DR,Jakab GJ,Trush MA

更新日期：1992-07-01 00:00:00

abstract：:Results of previous serologic studies on the association of human papillomavirus (HPV) with esophageal squamous cell carcinoma (ESCC) have been inconsistent. From 2007 to 2010, the authors collected blood samples and relevant demographic data from 1435 patients with ESCC and 2071 age- and sex-matched normal controls f...

journal_title：Carcinogenesis

authors： He Z,Xu Z,Hang D,Guo F,Abliz A,Weiss NS,Xi L,Liu F,Ning T,Pan Y,Guo C,Liang Y,Lu C,Zhang L,Cai H,Ke Y

更新日期：2014-04-01 00:00:00

abstract：:Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...

journal_title：Carcinogenesis

authors： Ding DP,Chen ZL,Zhao XH,Wang JW,Sun J,Wang Z,Tan FW,Tan XG,Li BZ,Zhou F,Shao K,Li N,Qiu B,He J

更新日期：2011-07-01 00:00:00

abstract：:The effects of in vivo exposure to DDT on hepatic gap junctional intercellular communication (GJIC) and connexin gene/protein expression in Sprague-Dawley rats were examined by in vivo/in vitro dye-transfer assay, immunohistochemical staining, and by Western and Northern blot analyses. In the dose-response study, thre...

journal_title：Carcinogenesis

authors： Tateno C,Ito S,Tanaka M,Oyamada M,Yoshitake A

更新日期：1994-03-01 00:00:00

abstract：:Oxidative DNA damage may be implicated in ageing, carcinogenesis and other degenerative diseases. Oxidative DNA damage can be assessed in humans in vivo from the urinary excretion of the DNA-repair product 8-hydroxydeoxyguanosine (8OHdG). We investigated factors influencing the excretion of 8OHdG in 24 h urine from 83...

journal_title：Carcinogenesis

authors： Loft S,Vistisen K,Ewertz M,Tjønneland A,Overvad K,Poulsen HE

更新日期：1992-12-01 00:00:00

abstract：:Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...

journal_title：Carcinogenesis

authors： Hacker HJ,Steinberg P,Bannasch P

更新日期：1998-01-01 00:00:00

abstract：:Previous metabolism and DNA-binding studies indicated that 5,6-dimethylchrysene (5,6-diMeC) is metabolically activated in mouse skin through formation of its 1,2-dihydrodiol (5,6-diMeC-1,2-diol) and bay region diol-epoxide (anti-5,6-diMeC-1,2-diol-3,4-epoxide). These metabolites were tested as tumor initiators on mous...

journal_title：Carcinogenesis

authors： Amin S,Desai D,Hecht SS

更新日期：1993-10-01 00:00:00

abstract：:Not all carcinogens are mutagens, and many mutagens are not carcinogens. Among related chemicals, small changes of structure can markedly influence carcinogenic potency. Many tumours are genetically unstable, but some, especially 'benign' types, rarely exhibit 'progression' or show other evidence of genetic instabilit...

journal_title：Carcinogenesis

authors： Bignold LP

更新日期：2004-03-01 00:00:00

abstract：:The inbred DRH rats are highly resistant to the induction of hepatocellular carcinoma (HCC) by feeding of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). Previously, we found that two quantitative trait loci (QTLs), Drh1 and Drh2, significantly reduced the number, size and area of glutathione S-transferase-placental ...

journal_title：Carcinogenesis

authors： Yan Y,Zeng ZZ,Higashi S,Denda A,Konishi Y,Onishi S,Ueno H,Higashi K,Hiai H

更新日期：2002-01-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...

journal_title：Carcinogenesis

authors： Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

更新日期：2014-08-01 00:00:00

abstract：:Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G2 phase. The reproducibility of this response suggested that it could pro...

journal_title：Carcinogenesis

authors： Takai S,Price FM,Sanford KK,Tarone RE,Parshad R

更新日期：1990-08-01 00:00:00

abstract：:Oltipraz (4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione) (OPZ) is recognized as a potent chemoprotective agent against chemical-induced carcinogenesis in several animal models and is thought to act mainly by inducing phase II conjugating together with inhibiting phase I detoxication enzymes. The present study was und...

journal_title：Carcinogenesis

authors： Antras-Ferry J,Mahéo K,Chevanne M,Dubos MP,Morel F,Guillouzo A,Cillard P,Cillard J

更新日期：1997-11-01 00:00:00

abstract：:The oxidative metabolites of estrogen have been proposed to play an important role in the development of some human cancers. The two major pathways of estrogen metabolism, to the carcinogenic 4-hydroxyestradiol (4-OHE2) and to the non-carcinogenic 2-hydroxyestradiol (2-OHE2), are mediated by cytochromes P450 CYP1B1 an...

journal_title：Carcinogenesis

authors： Husbeck B,Powis G

更新日期：2002-10-01 00:00:00

abstract：:5,9-Dimethyldibenzo[c,g]carbazole (DMDBC), a potent mouse hepatocarcinogen, has been shown to induce a non-linear increase in mutant frequency in the liver of the transgenic MutaMouse. To gain insight into the mechanisms underlying the mutagenicity of DMDBC in vivo, DNA damage formation and removal were monitored in m...

journal_title：Carcinogenesis

authors： Renault D,Brault D,Lossouarn Y,Périn-Roussel O,Taras-Valéro D,Périn F,Thybaud V

更新日期：2000-02-01 00:00:00

abstract：:We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first positi...

journal_title：Carcinogenesis

authors： Kamiya H,Murata-Kamiya N,Koizume S,Inoue H,Nishimura S,Ohtsuka E

更新日期：1995-04-01 00:00:00

abstract：:Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...

journal_title：Carcinogenesis

authors： Wild L,Funes JM,Boshoff C,Flanagan JM

更新日期：2010-10-01 00:00:00

abstract：:Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...

journal_title：Carcinogenesis

authors： Ishikawa TO,Oshima M,Herschman HR

更新日期：2011-03-01 00:00:00

abstract：:Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...

journal_title：Carcinogenesis

authors： Dragsted LO,Frandsen H,Reistad R,Alexander J,Larsen JC

更新日期：1995-11-01 00:00:00

abstract：:A pilot study was conducted to determine whether any relationship exists between micronucleated cell rates of female uterine cervical epithelium and current smoking status. Cervical uterine cells obtained from 118 pre-menopausal females, seen between September 1994 and June 1995 at the Occupational Medecine Interprofe...

journal_title：Carcinogenesis

authors： Lehucher-Michel MP,Favre-Eloff G,Devictor B,Duffaud F,Botta A

更新日期：1997-04-01 00:00:00

abstract：:Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...

journal_title：Carcinogenesis

authors： Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

更新日期：1991-07-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:Information suggests that the cyclooxygenase (COX) metabolites, the prostanoids, play a role in gall bladder physiology and disease. Non-steroidal anti-inflammatory drugs which inhibit COX enzymes have been shown in vivo and in vitro to alter the growth patterns of intestinal epithelial cells, and specific COX-2 inhib...

journal_title：Carcinogenesis

authors： Grossman EM,Longo WE,Panesar N,Mazuski JE,Kaminski DL

更新日期：2000-07-01 00:00:00

abstract：:In order to investigate the modulatory effect of the immune response induced by recurrent carcinogen exposure, anti-2-acetylaminofluorene (anti-2-AAF) IgG were elicited in Swiss mice before subsequent carcinogen administration. The immunization schedule consisted of three weekly i.p. injections of 2-acetylaminofluoren...

journal_title：Carcinogenesis

authors： Verdina A,Zito R,Cortese G,Leopardi P,Marcon F,Zijno A,Crebelli R

更新日期：1996-08-01 00:00:00

abstract：:Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...

journal_title：Carcinogenesis

authors： Kim BY,Kim KA,Kwon O,Kim SO,Kim MS,Kim BS,Oh WK,Kim GD,Jung M,Ahn JS

更新日期：2005-08-01 00:00:00

abstract：:Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...

journal_title：Carcinogenesis

authors： Yang R,Frank B,Hemminki K,Bartram CR,Wappenschmidt B,Sutter C,Kiechle M,Bugert P,Schmutzler RK,Arnold N,Weber BH,Niederacher D,Meindl A,Burwinkel B

更新日期：2008-02-01 00:00:00

abstract：:Despite their individual key roles in promoting head and neck squamous cell carcinoma (HNSCC) progression and treatment resistance, little is known about the impact of intratumoral hypoxia on the activity of the epidermal growth factor receptor (EGFR) signaling pathway in this cancer type. Here, we show that in highly...

journal_title：Carcinogenesis

authors： Wang X,Schneider A

更新日期：2010-07-01 00:00:00

abstract：:Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos an...

journal_title：Carcinogenesis

authors： Ledda-Columbano GM,Pibiri M,Molotzu F,Cossu C,Sanna L,Simbula G,Perra A,Columbano A

更新日期：2004-11-01 00:00:00

abstract：:Teleocidin, a new tumor promoter, increased incorporation of radioactive inorganic phosphate (32Pi) into phospholipids in HeLa cells. This effect was detected within 1 h on incubation of the cells in medium containing teleocidin. The half-maximum effective dose of teleocidin was approximately 10 ng/ml. The main effect...

journal_title：Carcinogenesis

authors： Nishino H,Fujiki H,Terada M,Sato S

更新日期：1983-01-01 00:00:00

abstract：:Woodchuck hepatocytes were immortalized with the simian virus 40 T antigen (SV40 T-ag) oncogene and utilized in an oncogenic transformation assay. Transfection of these cell lines with an activated C-Ha-ras oncogene (EJ6.6) resulted in the transformation of cells to a phenotype characterized by anchorage-independent g...

journal_title：Carcinogenesis

authors： Jacob JR,Tennant BC

更新日期：1996-04-01 00:00:00