Transformation of immortalized woodchuck hepatic cell lines with the c-Ha-ras proto-oncogene.

abstract：:The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...

journal_title：Carcinogenesis

authors： Lin M,Stewart DJ,Spitz MR,Hildebrandt MA,Lu C,Lin J,Gu J,Huang M,Lippman SM,Wu X

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...

journal_title：Carcinogenesis

authors： Truong T,Sauter W,McKay JD,Hosgood HD 3rd,Gallagher C,Amos CI,Spitz M,Muscat J,Lazarus P,Illig T,Wichmann HE,Bickeböller H,Risch A,Dienemann H,Zhang ZF,Naeim BP,Yang P,Zienolddiny S,Haugen A,Le Marchand L,Hong YC

更新日期：2010-04-01 00:00:00

abstract：:A culture method to grow two morphologically distinguishable normal human breast epithelial cell types derived from reduction mammoplasty has been developed. Type I cells were characterized by a more variable cell shape, smooth cell colony boundaries, the expression of epithelial membrane antigen (EMA) and keratin 18 ...

journal_title：Carcinogenesis

authors： Kao CY,Nomata K,Oakley CS,Welsch CW,Chang CC

更新日期：1995-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCL...

journal_title：Carcinogenesis

authors： Liu P,Morrison C,Wang L,Xiong D,Vedell P,Cui P,Hua X,Ding F,Lu Y,James M,Ebben JD,Xu H,Adjei AA,Head K,Andrae JW,Tschannen MR,Jacob H,Pan J,Zhang Q,Van den Bergh F,Xiao H,Lo KC,Patel J,Richmond T,Watt MA,

更新日期：2012-07-01 00:00:00

abstract：:Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...

journal_title：Carcinogenesis

authors： James SJ,Miller BJ,Basnakian AG,Pogribny IP,Pogribna M,Muskhelishvili L

更新日期：1997-02-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:Co-exposure to cadmium, cobalt, lead and other heavy metals occurs in many occupational settings, such as pigment and batteries production, galvanization and recycling of electric tools. However, little is known about interactions between several heavy metals. In the present study we determined DNA single strand break...

journal_title：Carcinogenesis

authors： Hengstler JG,Bolm-Audorff U,Faldum A,Janssen K,Reifenrath M,Götte W,Jung D,Mayer-Popken O,Fuchs J,Gebhard S,Bienfait HG,Schlink K,Dietrich C,Faust D,Epe B,Oesch F

更新日期：2003-01-01 00:00:00

abstract：:Nitrosamine-induced hepatocarcinogenesis has been used to investigate the regulation and expression of different drug-metabolizing enzymes in preneoplastic and neoplastic lesions in the female Wistar rat. The enzymes investigated were two phenobarbital-inducible cytochrome P-450 (cyt. P-450) isoenzymes (PB1 and PB2, m...

journal_title：Carcinogenesis

authors： Buchmann A,Kuhlmann W,Schwarz M,Kunz W,Wolf CR,Moll E,Friedberg T,Oesch F

更新日期：1985-04-01 00:00:00

abstract：:The glutathione transferases (GST) belonging to class pi are primarily responsible for the intracellular detoxification of the highly mutagenic and carcinogenic compound (+)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). The aim of the present investigation was to study the n...

journal_title：Carcinogenesis

authors： Swedmark S,Romert L,Morgenstern R,Jenssen D

更新日期：1992-10-01 00:00:00

abstract：:The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...

journal_title：Carcinogenesis

authors： Chen KS,Shepel LA,Haag JD,Heil GM,Gould MN

更新日期：1996-08-01 00:00:00

abstract：:A two-stage carcinogenesis experiment was performed in Syrian golden hamsters using a single intragastric initiation with 10 mg/kg body weight of 7,12-dimethylbenz[a]anthracene (DMBA) and repetitive topical promotion on the back skin with two different doses (80 and 160 mg, respectively) of benzoyl peroxide in 1 ml ac...

journal_title：Carcinogenesis

authors： Schweizer J,Loehrke H,Edler L,Goerttler K

更新日期：1987-03-01 00:00:00

abstract：:Four monoclonal antibodies, PhIP-1, -2, -3 and -4, have been produced that bind to PhIP (2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine), a mutagenic aromatic amine produced in meat by cooking. The immunogen was an analog of PhIP conjugated to a carrier protein through the 2-amino group of PhIP, leaving the pyridine...

journal_title：Carcinogenesis

authors： Vanderlaan M,Watkins BE,Hwang M,Knize MG,Felton JS

更新日期：1989-12-01 00:00:00

abstract：:The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The ...

journal_title：Carcinogenesis

authors： Yu Z,Mahadevan B,Löhr CV,Fischer KA,Louderback MA,Krueger SK,Pereira CB,Albershardt DJ,Baird WM,Bailey GS,Williams DE

更新日期：2006-10-01 00:00:00

abstract：:Dose-related differences in the binding of DNA reactive intermediates for three environmentally important complex mixture particulate extracts and a well-studied carcinogen, benzo[a]pyrene (BaP), were examined in female C-57 mice following multiple topical treatments ranging from 1 to 120 mg/mouse. Particulate extract...

journal_title：Carcinogenesis

authors： Gallagher JE,Jackson MA,George MH,Lewtas J

更新日期：1990-01-01 00:00:00

abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

journal_title：Carcinogenesis

authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

更新日期：1985-10-01 00:00:00

abstract：:A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...

journal_title：Carcinogenesis

authors： Brenner AV,Butler MA,Wang SS,Ruder AM,Rothman N,Schulte PA,Chanock SJ,Fine HA,Linet MS,Inskip PD

更新日期：2007-12-01 00:00:00

abstract：:The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective recept...

journal_title：Carcinogenesis

authors： Wagner K,Hemminki K,Grzybowska E,Klaes R,Burwinkel B,Bugert P,Schmutzler RK,Wappenschmidt B,Butkiewicz D,Pamula J,Pekala W,Försti A

更新日期：2006-09-01 00:00:00

abstract：:Both Snell dwarf mice (dw/dw) and their phenotypically normal heterozygotes (dw/+) were dosed with methylclofenapate (MCP) at daily intervals by gavage (25 mg/kg). Animals were killed at 12, 24, 36 and 72 h after the initial dose and the parameters of ploidy, nuclearity and DNA synthesis were measured in hepatocytes i...

journal_title：Carcinogenesis

authors： Styles JA,Kelly MD,Pritchard NR,Foster JR

更新日期：1990-03-01 00:00:00

abstract：:Barrett's esophagus (BE) and esophageal adenocarcinoma (ADC) is associated with reflux of duodenal contents. Cyclooxygenase (COX)-2 is over-expressed in BE and ADC, and supposedly contributes to esophageal carcinogenesis. The aim of this study is to investigate what effect a COX-2 inhibitor has on esophageal adenocarc...

journal_title：Carcinogenesis

authors： Oyama K,Fujimura T,Ninomiya I,Miyashita T,Kinami S,Fushida S,Ohta T,Koichi M

更新日期：2005-03-01 00:00:00

abstract：:The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-GAP. RNA from a total o...

journal_title：Carcinogenesis

authors： Müller O,Kress S,Schwarz M

更新日期：1992-10-01 00:00:00

abstract：:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...

journal_title：Carcinogenesis

authors： Tanaka T,Mori H,Williams GM

更新日期：1987-09-01 00:00:00

abstract：:Hepatocarcinogenesis was initiated in rats with a single dose of either of two chemical mutagens--benzo[a]pyrene diolepoxide I and methyl(acetoxymethyl)nitrosamine--administered 15 h after partial hepatectomy. The development of hepatocellular foci and neoplasms was then promoted with dietary phenobarbital given for 4...

journal_title：Carcinogenesis

authors： Kaufmann WK,Zhang Y,Kaufman DG

更新日期：1992-08-01 00:00:00

abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

journal_title：Carcinogenesis

authors： Randerath E,Zhou GD,Randerath K

更新日期：1996-12-01 00:00:00

abstract：:5-Aminolevulinic acid (ALA), a heme precursor accumulated in chemical and inborn porphyrias, may behave as an endogenous pro-oxidant. In chronically treated rats (40 mg ALA/kg body wt every 2 days for 15 days) the steady-state level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA (94.5 +/- 23.3 residues/10(6) dG)...

journal_title：Carcinogenesis

authors： Fraga CG,Onuki J,Lucesoli F,Bechara EJ,Di Mascio P

更新日期：1994-10-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...

journal_title：Carcinogenesis

authors： Petrilli FL,De Renzi GP,De Flora S

更新日期：1980-01-01 00:00:00

abstract：:We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...

journal_title：Carcinogenesis

authors： Yabu K,Warty VS,Gorelik E,Shinozuka H

更新日期：1991-01-01 00:00:00

abstract：:To explore the potential role for estrogen in lung cancer susceptibility, candidate single-nucleotide polymorphism (SNPs) in tobacco and estrogen metabolism genes were evaluated. Population-based cases (n = 504) included women aged 18-74, diagnosed with NSCLC in metropolitan Detroit between November 2001 and October 2...

journal_title：Carcinogenesis

authors： Cote ML,Yoo W,Wenzlaff AS,Prysak GM,Santer SK,Claeys GB,Van Dyke AL,Land SJ,Schwartz AG

更新日期：2009-04-01 00:00:00

abstract：:Treatment of pregnant mice with 3-methylcholanthrene (MC) causes lung and liver tumors in the offspring, the incidences of which are greatly influenced by the Ah locus regulated induction phenotype for aryl hydrocarbon hydroxylase activity (AHH) in both the mother and fetuses. In order to examine the biochemical and m...

journal_title：Carcinogenesis

authors： Miller MS,Jones AB,Chauhan DP,Anderson LM

更新日期：1990-11-01 00:00:00