Abstract:
:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2-diol-3,4-epoxide). The most mutagenic compound was anti-5-MeC-1,2-diol-3,4-epoxide, followed by syn-5-MeC-1,2-diol-3,4-epoxide. At the same doses, neither of the 6-MeC-1,2-diol-3,4-epoxides was mutagenic. These results demonstrate the enhancing effect on mutagenicity of a methyl group in the same bay region as the epoxide ring of a diol epoxide.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Amin S,Huie K,Hecht SS,Harvey RGdoi
10.1093/carcin/7.12.2067subject
Has Abstractpub_date
1986-12-01 00:00:00pages
2067-70issue
12eissn
0143-3334issn
1460-2180journal_volume
7pub_type
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