Inhibition of [125I]epidermal growth factor binding to murine fibroblasts and keratinocytes by irradiation with UV-B light. Evidence for a protein kinase C-independent mechanism.

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...

journal_title：Carcinogenesis

authors： Vredeveld LC,Rowland BD,Douma S,Bernards R,Peeper DS

更新日期：2010-02-01 00:00:00

abstract：:Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...

journal_title：Carcinogenesis

authors： Gupta RC,Dighe NR

更新日期：1984-03-01 00:00:00

abstract：:Lung tumors were induced in A/J mice by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the related compounds acetoxymethylmethylnitrosamine (AMMN) and 4-acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNKOAc). NNK both methylates and pyridyloxobutylates DNA while AMMN and...

journal_title：Carcinogenesis

authors： Ronai ZA,Gradia S,Peterson LA,Hecht SS

更新日期：1993-11-01 00:00:00

abstract：:The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate H...

journal_title：Carcinogenesis

authors： Ragin C,Liu JC,Jones G,Shoyele O,Sowunmi B,Kennett R,Groen HJ,Gibbs D,Blackman E,Esan M,Brandwein MS,Devarajan K,Bussu F,Chernock R,Chien CY,Cohen MA,Samir EM,Mikio S,D'Souza G,Funchain P,Eng C,Gollin SM,Hong

更新日期：2017-02-01 00:00:00

abstract：:A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...

journal_title：Carcinogenesis

authors： Ito N,Tsuda H,Tatematsu M,Inoue T,Tagawa Y,Aoki T,Uwagawa S,Kagawa M,Ogiso T,Masui T

更新日期：1988-03-01 00:00:00

abstract：:Evidence from live cell bioassays shows that the flat mucosa from patients with colon cancer exhibits resistance to bile salt-induced apoptosis. Three independent cell lines derived from the colonic epithelial cell line HCT-116 were selected for resistance to bile salt-induced apoptosis. These cell lines were develope...

journal_title：Carcinogenesis

authors： Crowley-Weber CL,Payne CM,Gleason-Guzman M,Watts GS,Futscher B,Waltmire CN,Crowley C,Dvorakova K,Bernstein C,Craven M,Garewal H,Bernstein H

更新日期：2002-12-01 00:00:00

abstract：:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...

journal_title：Carcinogenesis

authors： Stitzel KA,Horn PA,Ezra MF

更新日期：1990-12-01 00:00:00

abstract：:An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weekly injections of N-nitroso-bis(2-hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiation of the acinar c...

journal_title：Carcinogenesis

authors： Flaks B,Moore MA,Flaks A

更新日期：1982-01-01 00:00:00

abstract：:Benzidine diimine (BZDI), a reactive intermediate in the metabolic peroxidation of the carcinogen benzidine, has been reported to bind covalently to cellular proteins and nucleic acids. We have examined the nature of this interaction with DNA and have identified a major carcinogen-nucleoside adduct. BZDI (20-50 microM...

journal_title：Carcinogenesis

authors： Yamazoe Y,Roth RW,Kadlubar FF

更新日期：1986-01-01 00:00:00

abstract：:The hepatitis B virus X protein (HBx) has pleiotropic biological effects, which underlies its potential role in cell transformation. However, its involvement in hepatic fibrosis remains unclear. In this study, we wanted to clarify, in vivo, the role of HBx protein in the development of liver fibrosis. Mice transgenic ...

journal_title：Carcinogenesis

authors： Ahodantin J,Lekbaby B,Bou Nader M,Soussan P,Kremsdorf D

更新日期：2020-05-14 00:00:00

abstract：:Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...

journal_title：Carcinogenesis

authors： Miyamoto S,Yasui Y,Tanaka T,Ohigashi H,Murakami A

更新日期：2008-05-01 00:00:00

abstract：:Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes were studied in 69 full-time chimney sweeps and 35 controls, all male subjects. The sweeps had a higher (22%) but statistically non-significant ...

journal_title：Carcinogenesis

authors： Ichiba M,Hagmar L,Rannug A,Högstedt B,Alexandrie AK,Carstensen U,Hemminki K

更新日期：1994-07-01 00:00:00

abstract：:To indicate how readily nitrosamines (NAms) diffuse into the esophagus, we measured diffusion rate (flux) through rat esophagus of dialkyl-NAms using side-by-side diffusion apparatuses. Mucosal and serosal flux at 37 degrees C of two NAms, each at 50 microM, was followed for 90 min by gas chromatography-thermal energy...

journal_title：Carcinogenesis

authors： Haorah J,Miller DW,Brand R,Smyrk TC,Wang X,Chen SC,Mirvish SS

更新日期：1999-05-01 00:00:00

abstract：:DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...

journal_title：Carcinogenesis

authors： Kaufmann WK,Briley LP

更新日期：1990-01-01 00:00:00

abstract：:Two solid-phase extraction methods were developed for the determination of mutagenic heterocyclic aromatic amines in heated meat products. The copper phthalocyanine (CPC) tandem extraction was performed on coupled cartridges of diatomaceous earth and CPC-derivatized Sephasorb HP, followed by further clean-up on Sephas...

journal_title：Carcinogenesis

authors： Gross GA

更新日期：1990-09-01 00:00:00

abstract：:ROS1-fusion genes, resulting from chromosomal rearrangement, have been reported in 1-2% of human non-small cell lung cancer cases. More than 10 distinct ROS1-fusion genes, including break-point variants, have been identified to date. In this study, to investigate the in vivo oncogenic activities of one of the most fre...

journal_title：Carcinogenesis

authors： Inoue M,Toki H,Matsui J,Togashi Y,Dobashi A,Fukumura R,Gondo Y,Minowa O,Tanaka N,Mori S,Takeuchi K,Noda T

更新日期：2016-05-01 00:00:00

abstract：:High intake of red meat, but not of white meat, is associated with an increased risk of colon cancer. However, red meat does not promote cancer in rodents. Haemin, added to low-calcium diets, increases colonic proliferation, and haemoglobin, added to high-fat diets, increases the colon tumour incidence in rats, an eff...

journal_title：Carcinogenesis

authors： Pierre F,Taché S,Petit CR,Van der Meer R,Corpet DE

更新日期：2003-10-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...

journal_title：Carcinogenesis

authors： Clemons NJ,Shannon NB,Abeyratne LR,Walker CE,Saadi A,O'Donovan ML,Lao-Sirieix PP,Fitzgerald RC

更新日期：2010-09-01 00:00:00

abstract：:Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis. Despite significant advances in the current multimodality therapy including surgery, postoperative radiotherapy (RT) and temozolomide (TMZ)-based concomitant and adjuvant chemotherapy (CT), tumor recurrence is nearly universal with...

journal_title：Carcinogenesis

authors： Vengoji R,Ponnusamy MP,Rachagani S,Mahapatra S,Batra SK,Shonka N,Macha MA

更新日期：2019-03-12 00:00:00

abstract：:Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucl...

journal_title：Carcinogenesis

authors： Chen AA,Marsit CJ,Christensen BC,Houseman EA,McClean MD,Smith JF,Bryan JT,Posner MR,Nelson HH,Kelsey KT

更新日期：2009-06-01 00:00:00

abstract：:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...

journal_title：Carcinogenesis

authors： Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

更新日期：1988-03-01 00:00:00

abstract：:raf oncogenes have been implicated in hepatic carcinogenesis. We studied the effects of the v-raf of murine retrovirus 3611-MSV on the growth and differentiation of a simian virus 40 (SV40)-immortalized rat liver cell line (ALB-8) which maintained many of characteristics of differentiated hepatocytes. Cells were co-tr...

journal_title：Carcinogenesis

authors： Fang XJ,Keating A,Flowers M,Liew CC,Gupta H,Mills GB,Sherman M

更新日期：1993-04-01 00:00:00

abstract：:Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...

journal_title：Carcinogenesis

authors： Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

更新日期：1990-06-01 00:00:00

abstract：:There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP add...

journal_title：Carcinogenesis

authors： Swinnen LJ,Fisher SG,Erickson LC

更新日期：1989-08-01 00:00:00

abstract：:The urinary excretion of dimethylnitrosamine (DMN) was studied in male Sprague-Dawley rats. Animals were given DMN (3, 5, 10, 20, 30 and 50 mg/kg body weight, i.p.) or [3H]DMN (0.1, 1 and 3 mg; 8.7, 1.5 and 0.28 mCi/kg body weight, respectively, i.p.) diluted with sterile 0.9% NaCl. Urine was collected for 24 h after ...

journal_title：Carcinogenesis

authors： Kraft PL,Skipper PL,Charnley G,Tannenbaum SR

更新日期：1981-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...

journal_title：Carcinogenesis

authors： Song IS,Kim SU,Oh NS,Kim J,Yu DY,Huang SM,Kim JM,Lee DS,Kim NS

更新日期：2009-07-01 00:00:00

abstract：:Tea polyphenolic constituents induce apoptosis in cancer cells but not in normal cells. To study the mechanism of this selective effect, we used the ornithine decarboxylase (ODC)/Ras double transgenic mouse model that develops spontaneous skin tumors due to over-expression of ODC and a v-Ha-ras transgene. Administrati...

journal_title：Carcinogenesis

authors： Paul B,Hayes CS,Kim A,Athar M,Gilmour SK

更新日期：2005-01-01 00:00:00

abstract：:Exposure to diesel exhaust (DE) is known to cause lung tumors in rats. To clarify the mutagenicity of DE, we estimated mutant frequency (MF) and determined the mutation spectra in rat lung after exposure to DE using lambda/lacI transgenic rats (Big Blue system). Male Big Blue rats (6 weeks old) were exposed for 4 week...

journal_title：Carcinogenesis

authors： Sato H,Sone H,Sagai M,Suzuki KT,Aoki Y

更新日期：2000-04-01 00:00:00