Abstract:
:The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Ragin C,Liu JC,Jones G,Shoyele O,Sowunmi B,Kennett R,Groen HJ,Gibbs D,Blackman E,Esan M,Brandwein MS,Devarajan K,Bussu F,Chernock R,Chien CY,Cohen MA,Samir EM,Mikio S,D'Souza G,Funchain P,Eng C,Gollin SM,Hongdoi
10.1093/carcin/bgw203subject
Has Abstractpub_date
2017-02-01 00:00:00pages
218-229issue
2eissn
0143-3334issn
1460-2180pii
bgw203journal_volume
38pub_type
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