Abstract:
:As renal cell carcinomas are characterized by the disappearance of the transcription factor LFB1, which is known to be primarily involved in gene regulation in the liver, we have measured the presence of LFB1 in rat hepatocellular carcinomas induced by diethylnitrosamine. The level of LFB1 binding activity in adenoid-cystic as well as trabecular tumours shows some variation and may either be lower or higher than in the non-tumorous tissue. The amount of LFB1 binding activity correlates with the binding activity of HNF4, a transcription factor reported to stimulate LFB1 expression. As the levels of LFB1 and HNF4 binding activity differ extensively in various hepatocellular carcinomas, it is unlikely that these transcription factors play a general role in hepatocarcinogenesis. This is in contrast to renal carcinogenesis where a dramatic loss of LFB1 is a consistent feature.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Stumpf H,Senkel S,Rabes HM,Ryffel GUdoi
10.1093/carcin/16.1.143subject
Has Abstractpub_date
1995-01-01 00:00:00pages
143-5issue
1eissn
0143-3334issn
1460-2180journal_volume
16pub_type
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