Arsenite and cadmium promote the development of mammary tumors.

abstract：:Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...

journal_title：Carcinogenesis

authors： Otori K,Yano Y,Takada N,Lee CC,Hayashi S,Otani S,Fukushima S

更新日期：1997-08-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:Dose response studies regarding the cancer initiating potential of fumonisin B1 (FB1) were conducted as a function of time. Feeding studies over 21 days indicated that FB1 induced a feed refusal effect in rats at dietary levels of 250, 500 and 750 mg FB1/kg diet. This effect was overcome after 14 days and the feed int...

journal_title：Carcinogenesis

authors： Gelderblom WC,Cawood ME,Snyman SD,Marasas WF

更新日期：1994-02-01 00:00:00

abstract：:N-Nitrosobutyl(4-hydroxybutyl)amine (BBN) is a selective bladder carcinogen in rats. Its organ specificity may depend on several factors, including metabolic activation, DNA alkylation and repair within the target organ. Metabolic activation of BBN, which is asymmetrical, may result in butylating and 4-hydroxybutylati...

journal_title：Carcinogenesis

authors： Airoldi L,Magagnotti C,Bonfanti M,Chiappetta L,Lolli M,Medana C,De Gregorio G,Fanelli R

更新日期：1994-10-01 00:00:00

abstract：:Cyclooxygenases (COX) catalyse the oxygenation of arachidonic acid to prostaglandin (PG) endoperoxides. Activity of one of the COX isoforms, COX-2, results in production of prostaglandin E(2) (PGE(2)) via the endoperoxide PGH(2). COX-2 has been implicated in the pathogenesis of colorectal cancer. Malondialdehyde (MDA)...

journal_title：Carcinogenesis

authors： Sharma RA,Gescher A,Plastaras JP,Leuratti C,Singh R,Gallacher-Horley B,Offord E,Marnett LJ,Steward WP,Plummer SM

更新日期：2001-09-01 00:00:00

abstract：:Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...

journal_title：Carcinogenesis

authors： Plna K,Segerbäck D,Schweda EK

更新日期：1996-07-01 00:00:00

abstract：:We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency of CYP2D6 PM and GSTM1 B tended to be lower (P = 0.072 and P = 0.095...

journal_title：Carcinogenesis

authors： Perrett CW,Clayton RN,Pistorello M,Boscaro M,Scanarini M,Bates AS,Buckley N,Jones P,Fryer AA,Gilford J

更新日期：1995-07-01 00:00:00

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00

abstract：:Sixty-three male cigarette smokers were entered into a cross-sectional study to determine whether inverse associations existed between polycyclic aromatic hydrocarbon (PAH)-DNA adduct levels and intake/serum levels of vitamin A, vitamin C and vitamin E. Associations between PAH-DNA adducts and intakes of carotene, as ...

journal_title：Carcinogenesis

authors： Grinberg-Funes RA,Singh VN,Perera FP,Bell DA,Young TL,Dickey C,Wang LW,Santella RM

更新日期：1994-11-01 00:00:00

abstract：:There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...

journal_title：Carcinogenesis

authors： Zielinska-Park J,Nakamura J,Swenberg JA,Aitken MD

更新日期：2004-09-01 00:00:00

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...

journal_title：Carcinogenesis

authors： Dong Z,Cmarik JL,Wendel EJ,Colburn NH

更新日期：1994-05-01 00:00:00

abstract：:Tumor induction with chronic feeding of methyl-donor-deficient diets has been well established; however, the biochemical and molecular mechanisms which predipose to tumorigenesis in this model are still not well understood. The purpose of the present investigation was to assess DNA damage and altered nucleotide metabo...

journal_title：Carcinogenesis

authors： James SJ,Yin L

更新日期：1989-07-01 00:00:00

abstract：:The DNA damaging and mutagenic activities of procarbazine, a methylating drug employed in cancer chemotherapy and suspected of causing therapy-related leukaemia, were investigated in the liver and bone marrow of lambda lacZ transgenic mice (MutaMouse). The drug was administered using two different protocols, a 'high-d...

journal_title：Carcinogenesis

authors： Pletsa V,Valavanis C,van Delft JH,Steenwinkel MJ,Kyrtopoulos SA

更新日期：1997-11-01 00:00:00

abstract：:Administration of methylglyoxal at doses of 300-600 mg/kg body weight by gastric tube to male F344 rats induced 100-fold increase in ornithine decarboxylase activity (formation of 682 pmol CO2/30 min/mg protein) within 7 h, 26-fold increase in DNA synthesis (incorporation of 17 800 d.p.m. of [3H]thymidine/microgram DN...

journal_title：Carcinogenesis

authors： Furihata C,Sato Y,Matsushima T,Tatematsu M

更新日期：1985-01-01 00:00:00

abstract：:Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency ...

journal_title：Carcinogenesis

authors： Rogers AE,Akhtar R,Zeisel SH

更新日期：1990-09-01 00:00:00

abstract：:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...

journal_title：Carcinogenesis

authors： Iversen OH

更新日期：1982-01-01 00:00:00

abstract：:Dog urinary bladder is a target organ of carcinogenic arylamines. However, dog hepatic and urothelial cytosols lack acetylation enzymes that are capable of activating N-hydroxy metabolites of arylamines, suggesting that other enzymes may be involved. In the present study, we found that dog liver microsomes were capabl...

journal_title：Carcinogenesis

authors： Sone T,Zukowski K,Land SJ,King CM,Wang CY

更新日期：1991-10-01 00:00:00

abstract：:Carcinogenic tobacco-specific nitrosamines are present in tobacco products and are believed to play a significant role in human cancers associated with tobacco use. Additional amounts of tobacco-specific nitrosamines could be formed endogenously. We tested this hypothesis by treating rats with nicotine and sodium nitr...

journal_title：Carcinogenesis

authors： Carmella SG,Borukhova A,Desai D,Hecht SS

更新日期：1997-03-01 00:00:00

abstract：:The androgen receptor (AR) is involved in the development and progression of prostate cancer. In order to find new compounds that may present novel mechanisms to attenuate the function of AR, we investigated the effect of a natural flavonoid chemical, quercetin, on androgen action in an androgen-responsive LNCaP prost...

journal_title：Carcinogenesis

authors： Xing N,Chen Y,Mitchell SH,Young CY

更新日期：2001-03-01 00:00:00

abstract：:7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) was measured as an indicator of nickel-induced oxidative base damage in the presence of H2O2. Heterochromatic proteins isolated from Chinese hamster liver cells enhanced the formation of 8-oxo-dG induced by NiCl2 and H2O2 in vitro, whereas euchromatic proteins inhibited t...

journal_title：Carcinogenesis

authors： Huang X,Kitahara J,Zhitkovich A,Dowjat K,Costa M

更新日期：1995-08-01 00:00:00

abstract：:Progress in prostate cancer research has been hindered by the lack of well characterized, immortalized, human prostatic epithelial cell lines that express markers of normal prostatic epithelial cells and mimic normal growth and differentiation responses to androgens. The objectives of this study were to: (i) establish...

journal_title：Carcinogenesis

authors： Webber MM,Bello D,Kleinman HK,Wartinger DD,Williams DE,Rhim JS

更新日期：1996-08-01 00:00:00

abstract：:Several studies have indicated a correlation between the presence of inflammation and the development of cancer. The aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-diol), to an ultimate carcin...

journal_title：Carcinogenesis

authors： Petruska JM,Mosebrook DR,Jakab GJ,Trush MA

更新日期：1992-07-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Given our recent observation of the dehydro-epiandrosterone-mediated inhibition of protein isoprenylation and the fact that 99% of the circulating dehydro-epiandrosterone is sulfated, with less than 1...

journal_title：Carcinogenesis

authors： Schulz S,Nyce JW

更新日期：1994-11-01 00:00:00

abstract：:Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...

journal_title：Carcinogenesis

authors： Segerbäck D,Calleman CJ,Schroeder JL,Costa LG,Faustman EM

更新日期：1995-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide. Chronic inflammation appears to enhance the risk of CRC. Emerging evidence has suggested that epigenetic mechanisms play an important role in CRC. Aspirin [acetylsalicylic acid (ASA)] has been shown to prevent CRC; however, the epigenetic mechanisms of...

journal_title：Carcinogenesis

authors： Guo Y,Liu Y,Zhang C,Su ZY,Li W,Huang MT,Kong AN

更新日期：2016-06-01 00:00:00

abstract：:Cultures of isolated human hepatocytes from three different human liver specimens were exposed for 24 h to media containing [3H]benzo[a]pyrene (BP) (0.1, 1.0, 10, 100 microM). The cells and media were harvested and extracted. Subsequent incubations of the aqueous phase with beta-glucuronidase and aryl sulfatase, follo...

journal_title：Carcinogenesis

authors： Monteith DK,Novotny A,Michalopoulos G,Strom SC

更新日期：1987-07-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:Sulfur-containing substances derived from garlic and onion have been shown to prevent experimental carcinogenesis. One of the hypotheses explaining the mechanisms of the chemopreventive activity of these substances is that they activate detoxification systems such as glutathione S-transferase (GST). In this study the ...

journal_title：Carcinogenesis

authors： Hatono S,Jimenez A,Wargovich MJ

更新日期：1996-05-01 00:00:00

abstract：:Phosphorylation of proteins on serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase Pin1 and is a central signaling mechanism in cell proliferation and transformation. Although Pin1 is frequently overexpressed in hepatocellula...

journal_title：Carcinogenesis

authors： Lee NY,Choi HK,Shim JH,Kang KW,Dong Z,Choi HS

更新日期：2009-04-01 00:00:00