Abstract:
:The androgen receptor (AR) is involved in the development and progression of prostate cancer. In order to find new compounds that may present novel mechanisms to attenuate the function of AR, we investigated the effect of a natural flavonoid chemical, quercetin, on androgen action in an androgen-responsive LNCaP prostate cancer cell line. Western blot analysis showed that AR protein expression was inhibited by quercetin in a dose-dependent manner. To demonstrate that the repression effects on AR expression can actually reduce its function, we found that quercetin inhibited the secretion of the prostate-specific, androgen-regulated tumor markers, PSA and hK2. The mRNA levels of androgen-regulated genes such as PSA, NKX3.1 as well as ornithine decarboxylase (ODC) were down-regulated by quercetin. Transient transfections further showed that quercetin inhibited AR-mediated PSA expression at the transcription level. Finally, it was demonstrated that quercetin could repress the expression of the AR gene at the transcription level. Our result suggests that quercetin can attenuate the function of AR by repressing its expression and has the potential to become a chemopreventive and/or chemotherapeutic agent for prostate cancer.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Xing N,Chen Y,Mitchell SH,Young CYdoi
10.1093/carcin/22.3.409keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
409-14issue
3eissn
0143-3334issn
1460-2180journal_volume
22pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn079
更新日期:2008-05-01 00:00:00
abstract::Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to produce two transcripts, and the splicing pattern may be modulated by a G to A single nucleotide polymorphism within the sp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.2.257
更新日期:2002-02-01 00:00:00
abstract::Gangliosides from liver parenchymal and non-parenchymal cells were isolated from Fischer 344 rats that had been fed normal diet or a diet supplemented with 0.03% N-2-acetylaminofluorene (AAF) for 4 weeks. Gangliosides from liver cell fractions were characterized by an induction of both II3NeuAcIV3 alpha GalIV2FucGg4 a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.1.89
更新日期:1990-01-01 00:00:00
abstract::Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr109
更新日期:2011-08-01 00:00:00
abstract::The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.4.623
更新日期:1999-04-01 00:00:00
abstract::The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNA...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs376
更新日期:2013-03-01 00:00:00
abstract::The steroid hormone 1,25-dihydroxyvitamin D(3), [1,25(OH)(2)D(3), calcitriol], the active metabolite of vitamin D, exerts pleiotropic antitumor effects against several malignancies. However, the clinical use of this hormone is limited by hypercalcemia. 25-Hydroxyvitamin D(3), the prohormone of 1,25(OH)(2)D(3), is hydr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh086
更新日期:2004-06-01 00:00:00
abstract::Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.5.1161
更新日期:1995-05-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of short non-coding, single-stranded RNAs, which perform posttranscriptional regulatory functions as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) genes are currently being identified for contributing to cancer risk, prognosis and survival. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu082
更新日期:2014-07-01 00:00:00
abstract::Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm141
更新日期:2007-09-01 00:00:00
abstract::Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr197
更新日期:2011-12-01 00:00:00
abstract::Chronic oral administration of the carcinogenic aminoazo dye N-methyl-4-aminoazobenzene (MAB) to rats is known to result in the induction of liver tumors. In order to assess the role of carcinogen-DNA adduct formation in MAB hepatocarcinogenesis, male rats were fed 0.06% [3'-3H]MAB in the diet for 1, 3 or 5 weeks. Gro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.4.577
更新日期:1987-04-01 00:00:00
abstract::Bacterial formation of carcinogenic N-nitroso compounds may play a role in the etiology of human cancer. Biochemical and immunological studies in denitrifying bacteria (Pseudomonas aeruginosa) strongly support the identification of cytochrome cd(1)-nitrite reductase as the enzyme responsible for the catalysis of nitro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.3.533
更新日期:1996-03-01 00:00:00
abstract::SENCAR mice are unusually sensitive to induction of papillomas and squamous cell carcinomas by initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tumors induced by this protocol were tested for the presence of papillomavirus by immunohistochemistry, Southern...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.2.341
更新日期:1990-02-01 00:00:00
abstract::The localization of benzo[a]pyrene-deoxyguanosine adducts was studied by indirect immunofluorescence in cultured BALB/c epidermal cells exposed to (+/-) 7 alpha, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (the anti-isomer) utilizing an antiserum specific for the major benzo[a]pyrene-de...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.3.345
更新日期:1982-01-01 00:00:00
abstract::The effect of daily parenteral administration of a long-acting analogue of somatostatin (SMS 201-995) on the development of intestinal tumours and the rate of crypt cell proliferation in azoxymethane-treated rats has been studied. SMS 201-995 had no significant effect on the number of colonic tumours induced. In the d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.4.561
更新日期:1987-04-01 00:00:00
abstract::To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr091
更新日期:2011-09-01 00:00:00
abstract::The skin tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the chlorinated insecticide, endosulfan, are two potent inhibitors of gap junctional intercellular communication. In the present study the effects of TPA and endosulfan on cell communication have been investigated in IAR 20 rat liver epithelial ce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.6.1161
更新日期:1994-06-01 00:00:00
abstract::DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl239
更新日期:2007-06-01 00:00:00
abstract::The effect of a deoxycholic acid instillation on colonic epithelium was investigated and compared with the effect of an intervention scheme in which deoxycholic acid (DCA) treated mice received oral supplements of calcium lactate. The morphology of colonic tissue exposed to DCA was markedly affected when compared to t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.9.1205
更新日期:1983-09-01 00:00:00
abstract::Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgv127
更新日期:2015-11-01 00:00:00
abstract::Two of the major bacterial mutagens formed in heated meat products, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or the basic fraction of beef extract induced a low frequency of sister chromatid exchanges in human lymphocyte cultures in the presence of metabolic activation....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.429
更新日期:1989-03-01 00:00:00
abstract::Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.2.229
更新日期:1982-01-01 00:00:00
abstract::Aberrant crypt foci (ACF) are microscopic surface abnormalities that are putative precursors to colorectal cancer (CRC). ACF exhibit similar histological and molecular abnormalities to adenomas and CRC and potentially represent useful biomarkers of cancer risk. Microsatellite instability (MSI) is one molecular abnorma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl209
更新日期:2007-04-01 00:00:00
abstract::Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn126
更新日期:2008-07-01 00:00:00
abstract::Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells. Using two imm...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm185
更新日期:2007-12-01 00:00:00
abstract::Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq080
更新日期:2010-10-01 00:00:00
abstract::Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.11.2785
更新日期:1995-11-01 00:00:00
abstract::Progression of hepatic neoplasia was assessed in medaka (Oryzias latipes) following aqueous exposure to diethylnitrosamine (DEN). Larvae (2 weeks old) were exposed to 350 or 500 p.p.m. DEN for 48 h, while adults (3-6 months old) were exposed to 50 p.p.m. DEN for 5 weeks. Fish were maintained as long as possible to det...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.6.933
更新日期:1999-06-01 00:00:00
abstract::4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.8.1577
更新日期:1999-08-01 00:00:00