Abstract:
:Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors has been extensively studied and it is well known that they are aberrantly produced by cancer cells, macrophages and other phagocytic cells. Genetic polymorphisms are known in several cytokine genes, which result in altered expression. In the present association study, we investigated the association of 14 functional polymorphisms in 11 cytokines genes with BCC risk in 529 BCC cases and 532 healthy controls. We have also tested the possible interactions between the genetic variants and three known risk factors for BCC: skin complexion, sun effect and skin response to sun exposure. We did not observe any statistically significant association between SNPs and BCC risk. However, we found that, in a subgroup of subjects more prone to skin burns, carriers of at least one copy of the G allele of rs1800629 (TNF) had an increased risk of BCC [odds ratio (OR) = 2.40, 95% confidence interval (CI) 1.38-4.16, P = 0.0005]. Moreover, in subjects less prone to sunburns, we observed that carriers of the C allele of rs1143627 (IL1B) showed a decreased risk (OR = 0.53, 95% CI 0.34-0.82, P = 0.0019). In conclusion, we found that two polymorphisms in inflammatory genes interacting with environmental risk factors could modulate BCC risk.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Rizzato C,Canzian F,Rudnai P,Gurzau E,Stein A,Koppova K,Hemminki K,Kumar R,Campa Ddoi
10.1093/carcin/bgr197subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1849-54issue
12eissn
0143-3334issn
1460-2180pii
bgr197journal_volume
32pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Colonic epithelial cell migration is required for normal differentiated cell function. This migratory phenotype is dependent upon wild-type adenomatous polyposis coli (Apc) expression. Non-tumorigenic murine colon epithelial cell lines with distinct Apc genotypes, i.e. young adult mouse colon (YAMC; Apc(+/+)) and immo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.6.1065
更新日期:2002-06-01 00:00:00
abstract::The role of aflatoxin B1 (AFB1) in the induction of rearrangements affecting minisatellite sequences was studied in an in vitro yeast model. The Saccharomyces cerevisiae strain used expresses human cytochrome P450 1A2 and NADPH-cytochrome P450 oxidoreductase and has previously been used to study genetic recombination ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.9.1673
更新日期:1998-09-01 00:00:00
abstract::Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking. The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/23.12.1969
更新日期:2002-12-01 00:00:00
abstract::Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.5.765
更新日期:1985-05-01 00:00:00
abstract::Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.5.811
更新日期:1990-05-01 00:00:00
abstract::Monoterpenes have been shown to both prevent and treat mammary cancer in animal models and are currently in clinical testing in advanced cancer patients. In this study, we investigated a biochemical modulation associated with the antitumor activity of monoterpenes, the inhibition of protein isoprenylation in monoterpe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.5.827
更新日期:1998-05-01 00:00:00
abstract::The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn213
更新日期:2009-01-01 00:00:00
abstract::Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr283
更新日期:2012-02-01 00:00:00
abstract::DNA polymerase beta (polbeta) is a major contributor to mammalian DNA damage repair through its gap-filling DNA synthesis and 5'-deoxyribose phosphate lyase activities. In this way, polbeta plays pivotal roles in the repair of oxidative DNA damage, replication, embryonic survival, neuronal development, meiosis, apopto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl239
更新日期:2007-06-01 00:00:00
abstract::Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/15.9.1785
更新日期:1994-09-01 00:00:00
abstract::The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monoxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated. Various combinations of these enzymes were functionally expressed in COS-1 cell...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.10.1713
更新日期:1992-10-01 00:00:00
abstract::Vinyl carbamate epoxide (VCO) was found to possess strong electrophilic, mutagenic and carcinogenic activities. It reacted with water at 37 degrees C and pH 7.4 (phosphate buffer) to form glycolaldehyde and several related reducing compounds; none of these products were mutagenic for Salmonella typhimurium TA1535. Und...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.3.441
更新日期:1993-03-01 00:00:00
abstract::One of the most widely studied ultimate carcinogens, 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I), is fairly stable in organic solvents but hydrolyses rapidly in the presence of water. Routine use of BPDE-I stock solutions involves multiple cycles of warming to room temperature and return to f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.11.2133
更新日期:1988-11-01 00:00:00
abstract::The formation of thioether conjugates is an important pathway for inactivation of certain carcinogens. This study assessed the mechanism by which the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT) forms a glutathione conjugate (ANFT-SG). Peroxidatic metabolism of ANFT, in the presence of glutathione, r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.11.2087
更新日期:1992-11-01 00:00:00
abstract::Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with various biological phenomena. However, the role of glycolysis induce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx034
更新日期:2017-06-01 00:00:00
abstract::[14C]Benzo[a]pyrene (BP) was administered to male germfree rats. Urinary metabolites, constituting 9% of the administered radioactivity, were fractionated by lipophilic ion exchange chromatography. More than 80% of the urinary metabolites were conjugated, while neutral metabolites constituted 13-18%. The latter group ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.4.681
更新日期:1994-04-01 00:00:00
abstract::The in vivo formation of specific 7,12-dimethylbenz[a]-anthracene (DMBA)-DNA adducts in the mammary gland of the female Sprague-Dawley rat was studied in response to dietary butylated hydroxytoluene (BHT). Dietary BHT concentrations of 0.4 and 0.8% significantly inhibited total DMBA-DNA binding by 41.5 and 35.6% respe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.10.1967
更新日期:1991-10-01 00:00:00
abstract::The HBL100 cell line, established in vitro from milk of an apparently healthy woman, expresses SV40 large T antigen defective in some of its functions. Here we demonstrate that the HBL100 genomic DNA possesses transforming activity in NIH3T3 cells and that this activity is associated with the viral information. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.653
更新日期:1988-04-01 00:00:00
abstract::Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu238
更新日期:2015-02-01 00:00:00
abstract::E mu-pim-1 transgenic mice, which overexpress the pim-1 oncogene in lymphoid tissues, have shown increased susceptibility to induction of T cell lymphomas by N-ethyl-N-nitrosourea, a direct-acting chemical carcinogen (Nature, 340, 61-63, 1989). We sought to further evaluate E mu-pim-1 transgenic mice as a potential te...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.2.285
更新日期:1995-02-01 00:00:00
abstract::Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa044
更新日期:2020-08-12 00:00:00
abstract::Although Epstein-Barr virus (EBV) infection is widely distributed, certain EBV-driven malignancies are geographically restricted. EBV-associated Burkitt's lymphoma (eBL) is endemic in children living in sub-Saharan Africa. This population is heavily exposed to food contaminated with the mycotoxin aflatoxin B1 (AFB1). ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgv142
更新日期:2015-11-01 00:00:00
abstract::Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.8.737
更新日期:1981-01-01 00:00:00
abstract::The aim of this study was to investigate selected proteomic markers of the metabolic phenotype of breast carcinomas as prognostic markers of cancer progression. For this purpose, a series of 101 breast carcinomas and 13 uninvolved breast samples were examined for quantitative differences in protein expression of mitoc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi188
更新日期:2005-12-01 00:00:00
abstract::We have examined both the initial nuclease sensitivity and subsequent nucleosome rearrangement of newly repaired regions of chromatin in human diploid fibroblasts treated with methyl methanesulfonate (MMS) and methylnitrosourea (MNU). We initially examined the effect of these two alkylating agents on DNA replicative s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.2.245
更新日期:1984-02-01 00:00:00
abstract::An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalysed Fenton-like reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Glutathione S-transferase (GST) is a family of enzymes that play an important role in detoxi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.5.897
更新日期:1998-05-01 00:00:00
abstract::Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.773
更新日期:1991-05-01 00:00:00
abstract::Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm148
更新日期:2007-11-01 00:00:00
abstract::In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3H]AFB1-DNA binding). [3H]AFB1 was activated by both purified PHS and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1915
更新日期:1990-11-01 00:00:00
abstract::Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh195
更新日期:2004-10-01 00:00:00