Abstract:
:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obtained from 55 lung cancer patients to test whether any specific tumor-associated microbial features in lung microenvironment can be identified. Compared with non-malignant adjacent tissues, the tumor samples showed significantly lower community richness (α diversity), but no significant difference in overall microbiome dissimilarity (β diversity). Strong intrasubject correlations were observed between tumor sample and its paired non-malignant adjacent tissues. In addition, correlation network analysis found more significant taxa-taxa correlations (adjusted q-value < 0.05) in tumor microenvironment than non-malignant adjacent tissues. At taxa level, we found Propionibacterium genus were significantly reduced in tumor tissues compared with non-malignant adjacent tissues. In summary, the microbiota in tumor tissues showed the lower richness, higher taxa-taxa interaction, and reduction of potential pro-inflammatory microbial genera compared with non-malignant tissues, suggesting the potential link between the tumor microbiota and the altered tumor microenvironment for the further investigation.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu Ldoi
10.1093/carcin/bgaa044subject
Has Abstractpub_date
2020-08-12 00:00:00pages
1094-1103issue
8eissn
0143-3334issn
1460-2180pii
5870846journal_volume
41pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Arsenic is an established human carcinogen. Deficiencies in available animal models have inhibited a detailed analysis of the mechanism of arsenic induced cancer. This study sought to determine the role of a methyl-deficient diet in combination with sodium arsenite on the genomic methylation status and Ha-ras methylat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.5.777
更新日期:2002-05-01 00:00:00
abstract::Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq197
更新日期:2010-12-01 00:00:00
abstract::This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::Arsenicals are epidemiologically significant chemicals in relation to induction of urinary bladder cancer in man. In the present study, we investigated the dose-dependent promotion potential of dimethylarsinic acid (DMA), a major metabolite of inorganic arsenicals in mammals, for rat urinary bladder carcinogenesis. In...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.11.2435
更新日期:1996-11-01 00:00:00
abstract::There is some epidemiological support for a protective influence of omega-3 fatty acids against prostate cancer. We wanted to explore whether omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can affect androgen receptor function in prostate cancer cells. Our study ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/22.8.1201
更新日期:2001-08-01 00:00:00
abstract::We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi193
更新日期:2005-12-01 00:00:00
abstract::A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.577
更新日期:1983-01-01 00:00:00
abstract::Phosphoinositide-specific phospholipase Cgamma (PLCgamma) is a key regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain of certain activated receptors and catalyses the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] forming IP3 and diacylglycerol (DAG) in resp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.1.177
更新日期:1998-01-01 00:00:00
abstract::Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10(-5)) the association between 30 genomic regions and PDAC OS. With the aim...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw080
更新日期:2016-10-01 00:00:00
abstract::Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.2.283
更新日期:1992-02-01 00:00:00
abstract::To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp310
更新日期:2010-04-01 00:00:00
abstract::We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.7.1285
更新日期:1992-07-01 00:00:00
abstract::Calpains are cysteine proteases comprising members ubiquitously expressed in human tissues and other tissue-specific isoforms. Alterations of calpain 3 (p94), the muscle-specific isoform that contains three peculiar sequences (NS, IS1 and IS2), are strictly associated to the limb-girdle muscular dystrophy type 2A, in ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp098
更新日期:2009-06-01 00:00:00
abstract::1,3-Dimethyl-3-phenyl-1-nitrosourea (DMPNU) shows no spontaneous decomposition in aqueous buffered solution (pH 7.0) at 37 degrees C over a measuring period of 10 days, but it is directly genotoxic in all assays applied. This compound induces base substitutions in Salmonella typhimurium (especially in the plasmid harb...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.409
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare. METHODS:We studied the molecular pathology of 54 pancreatic adenocarcinomas from Egyptian patients ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm138
更新日期:2007-08-01 00:00:00
abstract::Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr197
更新日期:2011-12-01 00:00:00
abstract::Extensive tumorigenicity studies in rodents revealed that dibenzo[a,l]pyrene (DB[a,l]P) is the most potent carcinogen among all polycyclic aromatic hydrocarbons (PAHs) tested so far. The structure of the genotoxic metabolite(s) responsible for this exceptional carcinogenicity is unknown. The fjord-region syn- and anti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.11.2507
更新日期:1994-11-01 00:00:00
abstract::In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.3.465
更新日期:1994-03-01 00:00:00
abstract::Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq037
更新日期:2010-05-01 00:00:00
abstract::Lipid peroxidation aldehydes of the 4-hydroxy-alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated aldehyde, acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. In com...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.12.1755
更新日期:1985-12-01 00:00:00
abstract::An antibody (anti-EH) specific for microsomal epoxide hydrolase (mEH) from rhesus monkey liver has been used to test the immunochemical relationship between human liver mEH and the serum EH levels in human patients with hepatocellular carcinoma (HCC). Immunoblots of separated rhesus monkey and human liver microsomal p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.343
更新日期:1989-02-01 00:00:00
abstract::We have studied the influence of genetic polymorphisms in the xenobiotic-metabolizing genes GSTM1, GSTP1, GSTT1, EPHX1, NAT1 and NAT2 and the folate-metabolizing genes MTR and MTHFR on the frequencies of cells with chromosomal aberrations (CAs) in peripheral lymphocytes of Norwegian men. Log-linear Poisson regression ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq246
更新日期:2011-03-01 00:00:00
abstract::Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addres...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgv037
更新日期:2015-06-01 00:00:00
abstract::Azido-IQ (2-azido-3-methylimidazo[4,5-f]quinoline), a novel analog of the food mutagen and carcinogen IQ (2-amino-3-methylimidazo[4,5-f]quinoline) was synthesized and characterized. Both thermolysis and photolysis of this azide yield a short-lived nitrene which can react as an electrophile either directly or via proto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.5.869
更新日期:1988-05-01 00:00:00
abstract::Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing brea...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi302
更新日期:2006-04-01 00:00:00
abstract::The human guanylate-binding protein 1 (GBP-1) is among the proteins the most highly induced by interferon-γ (IFN-γ) in every cell type investigated as yet. In vivo, GBP-1 expression is associated with the presence of inflammation and has been observed in autoimmune diseases, inflammatory bowel diseases (IBD) and cance...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs310
更新日期:2013-01-01 00:00:00
abstract::We report evidence that the mutagen and carcinogen 3-amino-1-methyl-5H pyrido[4,3b]indole (Trp P-2) is a substrate for co-oxidation by prostaglandin H synthase (PHS) in ram seminal vesicle (RSV) microsomes. Trp P-2 serves as a reducing cofactor for the hydroperoxidase activity of PHS as shown by the concentration-depe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.8.1397
更新日期:1986-08-01 00:00:00
abstract::Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.4.585
更新日期:2000-04-01 00:00:00
abstract::Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp296
更新日期:2010-02-01 00:00:00
abstract::Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy034
更新日期:2018-05-28 00:00:00