The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).

abstract：:The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...

journal_title：Carcinogenesis

authors： Leng S,Stidley CA,Bernauer AM,Picchi MA,Sheng X,Frasco MA,Van Den Berg D,Gilliland FD,Crowell RE,Belinsky SA

更新日期：2008-07-01 00:00:00

abstract：:Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...

journal_title：Carcinogenesis

authors： Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

更新日期：2015-10-01 00:00:00

abstract：:TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues, although its oncogenic significance and molecular mechanisms are unknown. Previously, we have shown that TMPRSS4 promotes invasion, migration and metastasis of human tu...

journal_title：Carcinogenesis

authors： Kim S,Kang HY,Nam EH,Choi MS,Zhao XF,Hong CS,Lee JW,Lee JH,Park YK

更新日期：2010-04-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00

abstract：:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated to the ultimate mutagenic metabolite by CYP P450-mediated N-hydroxylation followed by phase II esterification. Incubation of N-hydroxy-PhIP (N-OH-PhI...

journal_title：Carcinogenesis

authors： Frandsen H,Alexander J

更新日期：2000-06-01 00:00:00

abstract：:Eight different forms of cytochrome P-450 have been isolated from the liver microsomes of male Sprague-Dawley rats and compared with previously characterized forms on the basis of chromatographic behavior, absorption maximum of the carbon monooxide complex, apparent molecular weight upon SDS-disc gel electrophoresis, ...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW

更新日期：1985-01-01 00:00:00

abstract：:Multiple myeloma (MM) cells accumulate in the bone marrow (BM) where their interactions impede disease therapy. We have shown that microvesicles (MVs) derived from BM mesenchymal stem cells (MSCs) of MM patients promote the malignant traits via modulation of translation initiation (TI), whereas MVs from normal donors ...

journal_title：Carcinogenesis

authors： Dabbah M,Jarchowsky-Dolberg O,Attar-Schneider O,Tartakover Matalon S,Pasmanik-Chor M,Drucker L,Lishner M

更新日期：2020-03-13 00:00:00

abstract：:Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases, relatively low and new methods, more specific and sensitive than classical cytogenetics, are probably needed to assess if c...

journal_title：Carcinogenesis

authors： Surrallés J,Autio K,Nylund L,Järventaus H,Norppa H,Veidebaum T,Sorsa M,Peltonen K

更新日期：1997-04-01 00:00:00

abstract：:The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...

journal_title：Carcinogenesis

authors： Weaver D,Amos A,Tierney B,Bresnick E

更新日期：1980-06-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwen...

journal_title：Carcinogenesis

authors： Girardi B,Principi M,Pricci M,Giorgio F,Iannone A,Losurdo G,Ierardi E,Di Leo A,Barone M

更新日期：2018-10-08 00:00:00

abstract：:Autoradiography has been used to study the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), 4-O-methyl TPA, and phorbol on metabolic cooperation between human diploid fibroblasts. When the donors, hypoxanthine-guanine phosphoribosyl transferase+ (HGPRT+) cells, and recipients, HGPRT- cells, were plated together i...

journal_title：Carcinogenesis

authors： Mosser DD,Bols NC

更新日期：1982-01-01 00:00:00

abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

journal_title：Carcinogenesis

authors： Hanigan MH,Winkler ML,Drinkwater NR

更新日期：1990-04-01 00:00:00

abstract：:Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...

journal_title：Carcinogenesis

authors： Wang TT,Hudson TS,Wang TC,Remsberg CM,Davies NM,Takahashi Y,Kim YS,Seifried H,Vinyard BT,Perkins SN,Hursting SD

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...

journal_title：Carcinogenesis

authors： Truong T,Sauter W,McKay JD,Hosgood HD 3rd,Gallagher C,Amos CI,Spitz M,Muscat J,Lazarus P,Illig T,Wichmann HE,Bickeböller H,Risch A,Dienemann H,Zhang ZF,Naeim BP,Yang P,Zienolddiny S,Haugen A,Le Marchand L,Hong YC

更新日期：2010-04-01 00:00:00

abstract：:Changes in lipid metabolism were monitored in rat hepatocyte nodules at certain time points over 9 months. Tissue obtained from partially hepatectomized rats, collected over a period of 7 days, were included as a control for normal hepatocyte cell proliferation. Two important features regarding the lipid profiles of h...

journal_title：Carcinogenesis

authors： Abel S,Smuts CM,de Villiers C,Gelderblom WC

更新日期：2001-05-01 00:00:00

abstract：:The three-dimensional structure of the product of the reaction of a diol epoxide of the carcinogen 5-methylchrysene with methanol has been determined by an X-ray diffraction analysis. The diol epoxide used to obtain this compound contains a stereochemically hindered bay region because of the location of the 5-methyl g...

journal_title：Carcinogenesis

authors： Afshar CE,Carrell CJ,Carrell HL,Harvey RG,Kiselyov AS,Amin S,Glusker JP

更新日期：1996-11-01 00:00:00

abstract：:Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...

journal_title：Carcinogenesis

authors： Maji S,Shriwas O,Samal SK,Priyadarshini M,Rath R,Panda S,Das Majumdar SK,Muduly DK,Dash R

更新日期：2019-03-12 00:00:00

abstract：:Botryodiplodin induces DNA-protein cross-links (DPC) in mammalian cells in culture. Removal of the mycotoxin followed by incubation of cells in fresh medium leads to the gradual disappearance of DPC. The present experiments attempted to determine to what extent the repair mechanism acts through a system involving tran...

journal_title：Carcinogenesis

authors： Moulé Y,Darracq N

更新日期：1984-10-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) was administered i.p. to male Wistar rats 17 h after partial hepatectomy. Hepatocytes were analyzed for the presence of micronuclei 7 h, 1, 2, 3 and 4 days after injection. N-OH-AAF treatment resulted in a high frequency of micronucleated hepatocytes at days 3 and 4 (19.5% an...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Mulder GJ,Meerman JH

更新日期：1989-04-01 00:00:00

abstract：:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...

journal_title：Carcinogenesis

authors： Birch JM,Marsden HB,Swindell R

更新日期：1982-01-01 00:00:00

abstract：:To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...

journal_title：Carcinogenesis

authors： Tang H,Dong X,Day RS,Hassan MM,Li D

更新日期：2010-04-01 00:00:00

abstract：:Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO). In the present study the activity of these three enzymes was estimated from ratios of the metabolites formed from dietary caffeine and excreted into the urine collected as spot samples. In the u...

journal_title：Carcinogenesis

authors： Vistisen K,Poulsen HE,Loft S

更新日期：1992-09-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...

journal_title：Carcinogenesis

authors： Calabrese C,Rizzello F,Gionchetti P,Calafiore A,Pagano N,De Fazio L,Valerii MC,Cavazza E,Strillacci A,Comelli MC,Poggioli G,Campieri M,Spisni E

更新日期：2016-06-01 00:00:00

abstract：:Alk(en)yl trisulfides (R-SSS-R') are organosulfur compounds produced by crushed garlic and other Allium vegetables. We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. Nine alk(en)yl trisulfides including dimethyl trisulfide, diethyl trisul...

journal_title：Carcinogenesis

authors： Hosono T,Hosono-Fukao T,Inada K,Tanaka R,Yamada H,Iitsuka Y,Seki T,Hasegawa I,Ariga T

更新日期：2008-07-01 00:00:00

abstract：:3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...

journal_title：Carcinogenesis

authors： Tretyakova N,Lin Y,Sangaiah R,Upton PB,Swenberg JA

更新日期：1997-01-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:Polymorphisms in 3' untranslated region (UTR) of cancer-related genes might affect regulation by microRNA (miRNA) and contribute to carcinogenesis. In this study, we screened several single nucleotide polymorphisms (SNPs) in 3'UTR of cancer-related genes and investigated their effects on the risk of esophageal squamou...

journal_title：Carcinogenesis

authors： Wang K,Li J,Guo H,Xu X,Xiong G,Guan X,Liu B,Li J,Chen X,Yang K,Bai Y

更新日期：2012-11-01 00:00:00