Abstract:
:The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analysis of the children's case records and their mothers' obstetric records showed an association between germ cell tumours and congenital malformations, particularly of the central nervous system, in the children themselves and in their stillborn sibs. An association between infections in pregnancy and early onset of tumours in the offspring was demonstrated. Other factors such as chronic illness in the mothers and drug-taking during pregnancy may be important, but further work is required to establish any definite associations.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Birch JM,Marsden HB,Swindell Rdoi
10.1093/carcin/3.1.75subject
Has Abstractpub_date
1982-01-01 00:00:00pages
75-80issue
1eissn
0143-3334issn
1460-2180journal_volume
3pub_type
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