Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.

abstract：:An important issue in current oncological research is prevention as well as early detection of cancer. This includes also the difficulty to predict the progression of early or pre-cancerous lesions to invasive cancer. In this context, the characterization and categorization of pre-neoplastic lesions of squamous cell c...

journal_title：Carcinogenesis

authors： Wittenborn J,Weikert L,Hangarter B,Stickeler E,Maurer J

更新日期：2020-12-31 00:00:00

abstract：:The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibite...

journal_title：Carcinogenesis

authors： Wattenberg LW,Coccia JB

更新日期：1991-01-01 00:00:00

abstract：:Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...

journal_title：Carcinogenesis

authors： Ishikawa TO,Oshima M,Herschman HR

更新日期：2011-03-01 00:00:00

abstract：:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats ...

journal_title：Carcinogenesis

authors： Imaida K,Lee MS,Land SJ,Wang CY,King CM

更新日期：1995-12-01 00:00:00

abstract：:The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria. Omeprazole-treated rats gavaged with nitrosation-proficient bacteria were treated with nitrosamines and/or precursors and comp...

journal_title：Carcinogenesis

authors： Calmels S,Béréziat JC,Ohshima H,Bartsch H

更新日期：1991-03-01 00:00:00

abstract：:When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...

journal_title：Carcinogenesis

authors： Guo X,Ruiz A,Rando RR,Bok D,Gudas LJ

更新日期：2000-11-01 00:00:00

abstract：:Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical dialkylnitrosamines with 2-5 carbon atoms per side chai...

journal_title：Carcinogenesis

authors： Richter E,Richter-Cooberg U,Feng X,Schulze J,Wiessler M

更新日期：1986-07-01 00:00:00

abstract：:The effects and mechanisms of action of diepoxybutane (DEB) and mitomycin C (MMC) were investigated on sea urchin embryogenesis, (Sphaerechinus granularis and Paracentrotus lividus). DEB- and MMC-induced toxicity was evaluated by means of selected end-points, including developmental defects, cytogenetic abnormalities ...

journal_title：Carcinogenesis

authors： Korkina LG,Deeva IB,De Biase A,Iaccarino M,Oral R,Warnau M,Pagano G

更新日期：2000-02-01 00:00:00

abstract：:Alterations in the pattern of epidermal cell differentiation and proliferation in mouse skin and benign skin tumors were studied by two-color immunofluorescence using monospecific antibodies. Replicating cells were identified by 5-bromo-deoxyuridine (BrdU) pulse-labeling and differentiating cells by keratins K1 and K1...

journal_title：Carcinogenesis

authors： Huitfeldt HS,Heyden A,Clausen OP,Thrane EV,Roop D,Yuspa SH

更新日期：1991-11-01 00:00:00

abstract：:The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...

journal_title：Carcinogenesis

authors： Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

更新日期：2006-09-01 00:00:00

abstract：:To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...

journal_title：Carcinogenesis

authors： Schaaper RM,Koffel-Schwartz N,Fuchs RP

更新日期：1990-07-01 00:00:00

abstract：:To investigate the mechanistic basis for the biological properties of anthocyanins, two aglycone anthocyanins [delphinidin (DY) and cyanidin (CY)] were used to examine their effects on cell cycle progression and on induction of apoptosis in human cancer cells (uterine carcinoma and colon adenocarcinoma cells) and in n...

journal_title：Carcinogenesis

authors： Lazzè MC,Savio M,Pizzala R,Cazzalini O,Perucca P,Scovassi AI,Stivala LA,Bianchi L

更新日期：2004-08-01 00:00:00

abstract：:The repair kinetics and sensitivity to inhibitors of DNA strand breaks caused by superoxide anion, hydrogen peroxide, benzoyl peroxide and anthralin have been studied and compared with strand breaks caused by well-studied agents such as ionizing radiation and bleomycin. The latter two agents are generally believed to ...

journal_title：Carcinogenesis

authors： Birnboim HC

更新日期：1986-09-01 00:00:00

abstract：:This study was designed to investigate the role of the epidermal growth factor receptor (EGFR) and its ligands in chemically induced mouse bladder cancer. Bladder tumours were induced in C57Bl/6 and B6D2F1 mice by treatment with the carcinogen, N:-butyl-N:-(4-hydroxybutyl) nitrosamine (BBN). The levels of mRNA for EGF...

journal_title：Carcinogenesis

authors： el-Marjou A,Delouvée A,Thiery JP,Radvanyi F

更新日期：2000-12-01 00:00:00

abstract：:Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency ...

journal_title：Carcinogenesis

authors： Rogers AE,Akhtar R,Zeisel SH

更新日期：1990-09-01 00:00:00

abstract：:Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases....

journal_title：Carcinogenesis

authors： Tebbi A,Levillayer F,Jouvion G,Fiette L,Soubigou G,Varet H,Boudjadja N,Cairo S,Hashimoto K,Suzuki AM,Carninci P,Carissimo A,di Bernardo D,Wei Y

更新日期：2016-01-01 00:00:00

abstract：:Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers, and most patients develop chemoresistance after first-line treatments. Despite recent advances, the 5-year relative survival is ~45% for all OC subtypes, and invasive epithelial OC has only a 17% survival rate when diagnosed at a late sta...

journal_title：Carcinogenesis

authors： Chuffa LGA,Reiter RJ,Lupi LA

更新日期：2017-10-01 00:00:00

abstract：:Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...

journal_title：Carcinogenesis

authors： Bak MJ,Furmanski P,Shan NL,Lee HJ,Bao C,Lin Y,Shih WJ,Yang CS,Suh N

更新日期：2018-07-30 00:00:00

abstract：:In this case-control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In individual single nucleotide polymorphis...

journal_title：Carcinogenesis

authors： Pan J,Lin J,Izzo JG,Liu Y,Xing J,Huang M,Ajani JA,Wu X

更新日期：2009-05-01 00:00:00

abstract：:The mutagenicity of N-nitroso-N-benzyl-methylamine (NBzMA), N-benzyl-N-nitrosourea (BzNU) and N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium strains was investigated. BzNU selectively mutated TA100 strain as compared to TA1535, whereas MNU showed an inverse strain response, an effect probably related to the fa...

journal_title：Carcinogenesis

authors： Lin DX,Malaveille C,Park SS,Gelboin HV,Bartsch H

更新日期：1990-09-01 00:00:00

abstract：UNLABELLED:Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) is recognized as oncogenic and simulative role on tumorigenesis by virtue of abnormal expression in cancer including nasopharyngeal carcinoma (NPC). We hypothesized that the copy number variation (CNV)-30450, which duplicates the MAPKAPK2...

journal_title：Carcinogenesis

authors： Yang L,Liu B,Qiu F,Huang B,Li Y,Huang D,Yang R,Yang X,Deng J,Jiang Q,Zhou Y,Lu J

更新日期：2014-01-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats and to determine whether mutations induced in this marker gene can be ...

journal_title：Carcinogenesis

authors： Meng Q,Recio L,Reilly AA,Wong BA,Bauer M,Walker VE

更新日期：1998-06-01 00:00:00

abstract：:Lipid peroxidation aldehydes of the 4-hydroxy-alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated aldehyde, acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. In com...

journal_title：Carcinogenesis

authors： Krokan H,Grafstrom RC,Sundqvist K,Esterbauer H,Harris CC

更新日期：1985-12-01 00:00:00

abstract：:In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure have not been observed in B6C3F1 mice. The recently completed o-nitrotoluene study provided the first cecal tumor response and an opportunity to evaluate the mor...

journal_title：Carcinogenesis

authors： Sills RC,Hong HL,Flake G,Moomaw C,Clayton N,Boorman GA,Dunnick J,Devereux TR

更新日期：2004-04-01 00:00:00

abstract：:We describe studies to determine if susceptibility to pituitary tumours is associated with the putatively high risk GSTM1 null and CYP2D6 EM genotypes. Frequency distributions of these genotypes were similar in cases and controls though the frequency of CYP2D6 PM and GSTM1 B tended to be lower (P = 0.072 and P = 0.095...

journal_title：Carcinogenesis

authors： Perrett CW,Clayton RN,Pistorello M,Boscaro M,Scanarini M,Bates AS,Buckley N,Jones P,Fryer AA,Gilford J

更新日期：1995-07-01 00:00:00

abstract：:The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...

journal_title：Carcinogenesis

authors： Leng S,Stidley CA,Bernauer AM,Picchi MA,Sheng X,Frasco MA,Van Den Berg D,Gilliland FD,Crowell RE,Belinsky SA

更新日期：2008-07-01 00:00:00

abstract：:Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...

journal_title：Carcinogenesis

authors： Thybaud-Lambay V,Decloitre F,Moulé Y,Florentin Y

更新日期：1983-01-01 00:00:00

abstract：:Desmosomes are intercellular junctions that confer strong cell-cell adhesion. Altered expression of desmocollin 3 (DSC3), a member of the desmosomal cadherin family, was found in various cancers; however, its functional involvement in carcinogenesis has not yet been elucidated. Expression/localization of DSC3 was anal...

journal_title：Carcinogenesis

authors： Cui T,Chen Y,Yang L,Knösel T,Huber O,Pacyna-Gengelbach M,Petersen I

更新日期：2012-12-01 00:00:00

abstract：:The role of aflatoxin B1 (AFB1) in the induction of rearrangements affecting minisatellite sequences was studied in an in vitro yeast model. The Saccharomyces cerevisiae strain used expresses human cytochrome P450 1A2 and NADPH-cytochrome P450 oxidoreductase and has previously been used to study genetic recombination ...

journal_title：Carcinogenesis

authors： Kaplanski C,Wild CP,Sengstag C

更新日期：1998-09-01 00:00:00