Abstract:
:The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibited pulmonary adenoma formation and the occurrence of forestomach tumors. In an additional experiment, D-limonene given p.o. 1 h prior to NNK administered i.p. again showed pronounced inhibition of pulmonary adenoma formation. This study provides additional data demonstrating that non-nutrient constituents of the diet can inhibit carcinogen-induced neoplasia when administered at a short time interval prior to carcinogen challenge.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Wattenberg LW,Coccia JBdoi
10.1093/carcin/12.1.115subject
Has Abstractpub_date
1991-01-01 00:00:00pages
115-7issue
1eissn
0143-3334issn
1460-2180journal_volume
12pub_type
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