Diet, GSTM1 and GSTT1 and head and neck cancer.

abstract：:The epidermal growth factor receptor (EGFR) pathway has recently been appreciated as a central mediator of tumorigenesis and an important drug target; however, the influence of genetic variation in this pathway on bladder cancer is not understood. Pathway activation leads to cell proliferation, angiogenesis and is ant...

journal_title：Carcinogenesis

authors： Mason RA,Morlock EV,Karagas MR,Kelsey KT,Marsit CJ,Schned AR,Andrew AS

更新日期：2009-07-01 00:00:00

abstract：:Ouabain resistance (ouar) and 6-thioguanine resistance (6-TGr) mutation frequencies were measured in Chinese hamster ovary cells after treatment with N-ethyl-N-nitrosourea (ENU) for varying periods of time. Maximal mutation frequency at the Na+/K+ ATPase gene locus (ouar mutations) was attained within 5 min of exposur...

journal_title：Carcinogenesis

authors： Dogliotti E,Vitelli A,Terlizzese M,Di Muccio A,Calcagnile A,Saffiotti U,Bignami M

更新日期：1987-01-01 00:00:00

abstract：:The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...

journal_title：Carcinogenesis

authors： Lin M,Stewart DJ,Spitz MR,Hildebrandt MA,Lu C,Lin J,Gu J,Huang M,Lippman SM,Wu X

更新日期：2011-07-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...

journal_title：Carcinogenesis

authors： Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

更新日期：2010-09-01 00:00:00

abstract：:Common polymorphisms in genes encoding phase I and phase II enzymes are considered to modify lung cancer risk due to changes in enzyme activity. Candidates include genetic variants of glutathione S-transferases (GSTM1, GSTT1 and GSTP1) and myeloperoxidase (MPO). We performed a large case-control study of these candida...

journal_title：Carcinogenesis

authors： Larsen JE,Colosimo ML,Yang IA,Bowman R,Zimmerman PV,Fong KM

更新日期：2006-03-01 00:00:00

abstract：:Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and induces tumors in the nasal tissues of experimental animals. Propylene oxide, like related alkylating agents, forms several different adducts with DNA bases, but predominantly at the 7-position o...

journal_title：Carcinogenesis

authors： Plna K,Nilsson R,Koskinen M,Segerbäck D

更新日期：1999-10-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...

journal_title：Carcinogenesis

authors： Zhang Y,Roth JA,Yu H,Ye Y,Xie K,Zhao H,Chang DW,Huang M,Li H,Qu J,Wu X

更新日期：2019-07-04 00:00:00

abstract：:The aim of this study has been to define cytotoxic mechanisms that may cause clonal expansion in the liver of pre-carcinogenic cells. An in vitro model, which has been described previously, was used. Hepatocytes were isolated from carcinogen-treated rats and a high proportion of the cells were gamma-glutamyltranspepti...

journal_title：Carcinogenesis

authors： Stenius U,Rubin K,Gullberg D,Högberg J

更新日期：1990-01-01 00:00:00

abstract：:A remodeling of calcium homeostasis has been identified as a characterizing feature of some cancers. Possible consequences of this include alterations in many pivotal physiological responses including apoptosis, proliferation and gene transcription. An alteration in calcium homeostasis can occur via changes in the exp...

journal_title：Carcinogenesis

authors： Aung CS,Ye W,Plowman G,Peters AA,Monteith GR,Roberts-Thomson SJ

更新日期：2009-11-01 00:00:00

abstract：:Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from...

journal_title：Carcinogenesis

authors： Iorns E,Martens-de Kemp SR,Lord CJ,Ashworth A

更新日期：2009-10-01 00:00:00

abstract：:Apoptosis, a form of programmed cell death, plays a fundamental role in the maintenance of tissues and organ systems by providing a controlled cell deletion to balanced cell proliferation. The last decade has witnessed an exponential increase in the number of studies investigating how different components of the diet ...

journal_title：Carcinogenesis

authors： Khan N,Afaq F,Mukhtar H

更新日期：2007-02-01 00:00:00

abstract：:The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, ...

journal_title：Carcinogenesis

authors： van Ravenzwaay B,Tennekes H,Stöhr M,Kunz W

更新日期：1987-02-01 00:00:00

abstract：:Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...

journal_title：Carcinogenesis

authors： Lee JJ,Natsuizaka M,Ohashi S,Wong GS,Takaoka M,Michaylira CZ,Budo D,Tobias JW,Kanai M,Shirakawa Y,Naomoto Y,Klein-Szanto AJ,Haase VH,Nakagawa H

更新日期：2010-03-01 00:00:00

abstract：:The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...

journal_title：Carcinogenesis

authors： Knasmüller S,Huber WW,Kienzl H,Schulte-Hermann R

更新日期：1992-09-01 00:00:00

abstract：:Using whole blood from 15 twin pairs discordant for breast cancer and high-resolution (450K) DNA methylation analysis, we identified 403 differentially methylated CpG sites including known and novel potential breast cancer genes. Confirming the results in an independent validation cohort of 21 twin pairs determined th...

journal_title：Carcinogenesis

authors： Heyn H,Carmona FJ,Gomez A,Ferreira HJ,Bell JT,Sayols S,Ward K,Stefansson OA,Moran S,Sandoval J,Eyfjord JE,Spector TD,Esteller M

更新日期：2013-01-01 00:00:00

abstract：:The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...

journal_title：Carcinogenesis

authors： Homma Y,Kondo Y,Kaneko M,Kitamura T,Nyou WT,Yanagisawa M,Yamamoto Y,Kakizoe T

更新日期：2004-06-01 00:00:00

abstract：:Thymidine kinase (TK), the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 15 specimens of normal mucosa, 14 polyps and 14 carcinomas in human colon. The average TK activities in colon polyps and carcinomas were about 1.6 and 2.9 times that in normal colon mucosa, respectively. The colon TK...

journal_title：Carcinogenesis

authors： Sakamoto S,Sagara T,Iwama T,Kawasaki T,Okamoto R

更新日期：1985-06-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:The effect of co-administration of diethylnitrosamine (DEN) and Clophen A 50, a commercial mixture of polychlorinated biphenyls (PCB), on pre-neoplastic enzyme-altered islands in livers of female Sprague-Dawley rats was studied. The islands were identified by the loss of adenosine-5'-triphosphatase (ATPase), emergence...

journal_title：Carcinogenesis

authors： Deml E,Oesterle D

更新日期：1986-10-01 00:00:00

abstract：:DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...

journal_title：Carcinogenesis

authors： Imai K,Yamamoto H

更新日期：2008-04-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...

journal_title：Carcinogenesis

authors： Wang K,Tu Y,Wan JB,Chen M,He C

更新日期：2020-07-10 00:00:00

abstract：:Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old. Biochemical parameters were measured d...

journal_title：Carcinogenesis

authors： Hietanen E,Bartsch H,Ahotupa M,Béréziat JC,Bussacchini-Griot V,Cabral JR,Camus AM,Laitinen M,Wild H

更新日期：1991-04-01 00:00:00

abstract：:The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...

journal_title：Carcinogenesis

authors： Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

更新日期：2005-10-01 00:00:00

abstract：:Examination of p53 mutation spectra may provide clues to molecular mechanisms involved in different histologic types of gastric cancer. A total of 105 gastric cancer cases classified according to the Laurén's system were selected from a high-risk area around Florence, Italy. Exons 5-8 of the p53 gene were examined for...

journal_title：Carcinogenesis

authors： Shiao YH,Palli D,Buzard GS,Caporaso NE,Amorosi A,Saieva C,Fraumeni JF Jr,Anderson LM,Rice JM

更新日期：1998-12-01 00:00:00

abstract：:An increased neuroendocrine (NE) cell population in prostate cancer is associated with more aggressive disease and recurrence after androgen-deprivation therapy, although the mechanism responsible is unknown. In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence ...

journal_title：Carcinogenesis

authors： Cortés MA,Cariaga-Martinez AE,Lobo MV,Martín Orozco RM,Motiño O,Rodríguez-Ubreva FJ,Angulo J,López-Ruiz P,Colás B

更新日期：2012-06-01 00:00:00

abstract：:The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both...

journal_title：Carcinogenesis

authors： Gill JH,James NH,Roberts RA,Dive C

更新日期：1998-02-01 00:00:00

abstract：:Heat treatment of foods containing reducing sugars and amino acids during cooking or sterilization triggers a sequence of non-enzymatic reactions collectively known as the Maillard reaction. 5-Hydroxymethylfurfural (HMF), one of the major intermediate products in the Maillard reaction, has been found to possess cytoto...

journal_title：Carcinogenesis

authors： Surh YJ,Liem A,Miller JA,Tannenbaum SR

更新日期：1994-10-01 00:00:00

abstract：:Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...

journal_title：Carcinogenesis

authors： Zhang S,Lu J,Zhao X,Wu W,Wang H,Lu J,Wu Q,Chen X,Fan W,Chen H,Wang F,Hu Z,Jin L,Wei Q,Shen H,Huang W,Lu D

更新日期：2010-07-01 00:00:00

abstract：:The accumulation of O6-methylguanine (O6-meG) in the DNA of blood leukocytes of 21 Hodgkin's lymphoma patients (followed for up to 12 cycles of treatment) treated in the context of MOPP combination chemotherapy with 150 mg procarbazine daily for 10 days was examined and compared to that observed in rats treated with d...

journal_title：Carcinogenesis

authors： Souliotis VL,Valavanis C,Boussiotis VA,Pangalis GA,Kyrtopoulos SA

更新日期：1994-08-01 00:00:00