Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine.

abstract：:Oltipraz (4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione) (OPZ) is recognized as a potent chemoprotective agent against chemical-induced carcinogenesis in several animal models and is thought to act mainly by inducing phase II conjugating together with inhibiting phase I detoxication enzymes. The present study was und...

journal_title：Carcinogenesis

authors： Antras-Ferry J,Mahéo K,Chevanne M,Dubos MP,Morel F,Guillouzo A,Cillard P,Cillard J

更新日期：1997-11-01 00:00:00

abstract：:The faecal concentration of substances responding to the chemical test for N-nitroso compounds (apparent total N-nitroso compounds, ATNC) was investigated in human subjects consuming their normal free-choice diet. Concentrations ranged from 40 to 590 micrograms (N-NO)/kg faeces. To ascertain the likely relative contri...

journal_title：Carcinogenesis

authors： Rowland IR,Granli T,Bøckman OC,Key PE,Massey RC

更新日期：1991-08-01 00:00:00

abstract：:To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...

journal_title：Carcinogenesis

authors： Bost KL,Garrett LR,Cuchens MA

更新日期：1986-08-01 00:00:00

abstract：:Recent studies indicate that cytochrome P450 (P450) 3A4 plays important roles in the activation of procarcinogens such as aflatoxin B1 and sterigmatocystin, as well as in the oxidation of a number of structurally diverse chemicals and endogenous compounds. Since P450 3A5 has been reported to be present at significant ...

journal_title：Carcinogenesis

authors： Yamazaki H,Inui Y,Wrighton SA,Guengerich FP,Shimada T

更新日期：1995-09-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth factor (TGF)-beta1-mediated epithelial-to-mesenchymal transition (EMT...

journal_title：Carcinogenesis

authors： Natsuizaka M,Ohashi S,Wong GS,Ahmadi A,Kalman RA,Budo D,Klein-Szanto AJ,Herlyn M,Diehl JA,Nakagawa H

更新日期：2010-08-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00

abstract：:The carcinogenic heterocyclic amine 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline (MeIQx) is widely distributed in cooked foods. The nuclease P1 method increased the sensitivity of the standard 32P-postlabeling analysis about 1000-fold for detection of MeIQx-DNA adducts. The recovery of MeIQx-DNA adducts by the nucle...

journal_title：Carcinogenesis

authors： Ochiai M,Nagaoka H,Wakabayashi K,Tanaka Y,Kim SB,Tada A,Nukaya H,Sugimura T,Nagao M

更新日期：1993-10-01 00:00:00

abstract：:The carcinogenic effects of in utero exposure to 3-methylcholanthrene (MC) have been demonstrated in the tumor-resistant C57BL/6 (B6) and DBA (D2) strains of mice. In this study, we determined the effects of in utero exposure to MC in BALB/c mice, a strain which demonstrates greater susceptibility to lung tumor induct...

journal_title：Carcinogenesis

authors： Gressani KM,Leone-Kabler S,O'Sullivan MG,Case LD,Malkinson AM,Miller MS

更新日期：1999-11-01 00:00:00

abstract：:Despite their individual key roles in promoting head and neck squamous cell carcinoma (HNSCC) progression and treatment resistance, little is known about the impact of intratumoral hypoxia on the activity of the epidermal growth factor receptor (EGFR) signaling pathway in this cancer type. Here, we show that in highly...

journal_title：Carcinogenesis

authors： Wang X,Schneider A

更新日期：2010-07-01 00:00:00

abstract：:On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwen...

journal_title：Carcinogenesis

authors： Girardi B,Principi M,Pricci M,Giorgio F,Iannone A,Losurdo G,Ierardi E,Di Leo A,Barone M

更新日期：2018-10-08 00:00:00

abstract：:Caucasian renal transplant recipients from Queensland, Australia have the highest non-melanoma skin cancer (NMSC) risk worldwide. Although ultraviolet light (UVR) exposure is critical, genetic factors also appear important. We and others have shown that polymorphism in the glutathione S-transferases (GST) is associate...

journal_title：Carcinogenesis

authors： Fryer AA,Ramsay HM,Lovatt TJ,Jones PW,Hawley CM,Nicol DL,Strange RC,Harden PN

更新日期：2005-01-01 00:00:00

abstract：:Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....

journal_title：Carcinogenesis

authors： Lockhart ML,Rosenberg BH

更新日期：1983-01-01 00:00:00

abstract：:Covalent binding of [7-3H]styrene (S) to DNA in vivo was measured and evaluated in a quantitative manner in order to investigate whether DNA adduct formation could form a mechanistic basis for tumor induction in a carcinogenicity bioassay. [7-3H]S was administered by inhalation in a closed chamber to male and female C...

journal_title：Carcinogenesis

authors： Cantoreggi S,Lutz WK

更新日期：1993-03-01 00:00:00

abstract：:A growing number of studies indicate a link between oxidative stress and cancer. We previously developed a rat model of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Here, we performed a genome-wide analysis to study characteristics of genomic alteration and identify putative genes involved ...

journal_title：Carcinogenesis

authors： Zhong Y,Onuki J,Yamasaki T,Ogawa O,Akatsuka S,Toyokuni S

更新日期：2009-01-01 00:00:00

abstract：:In order to understand the possible role of reactive intermediates in the formation of tissue-specific DNA damage by chromium(VI), electron paramagnetic resonance spectroscopy was used to study the in vivo formation of chromium(V) in the liver and red blood cells of 14 day chick embryos following treatment with chromi...

journal_title：Carcinogenesis

authors： Liebross RH,Wetterhahn KE

更新日期：1992-11-01 00:00:00

abstract：:We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first positi...

journal_title：Carcinogenesis

authors： Kamiya H,Murata-Kamiya N,Koizume S,Inoue H,Nishimura S,Ohtsuka E

更新日期：1995-04-01 00:00:00

abstract：:To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...

journal_title：Carcinogenesis

authors： Schaaper RM,Koffel-Schwartz N,Fuchs RP

更新日期：1990-07-01 00:00:00

abstract：:The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...

journal_title：Carcinogenesis

authors： Wiestler OD,Schmerold I,Fringes B,Volk B,Kleihues P

更新日期：1985-09-01 00:00:00

abstract：:X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) are mainly involved in base excision repair (BER) and nucleotide excision repair (NER) of DNA repair pathways, respectively. Polymorphisms of DNA repair gene XRCC1 and XPD has recently been identified, and there is a growing body ...

journal_title：Carcinogenesis

authors： Chen S,Tang D,Xue K,Xu L,Ma G,Hsu Y,Cho SS

更新日期：2002-08-01 00:00:00

abstract：:The repair of u.v.-induced damage in human and rodent cells was investigated at the level of DNA loops attached to the nuclear matrix. After 2 h post-u.v. incubation, DNase I digestion studies revealed a 3- to 4-fold enrichment of repair-labeled DNA at the nuclear matrix in four xeroderma pigmentosum cell strains belo...

journal_title：Carcinogenesis

authors： Mullenders LH,van Kesteren AC,Bussmann CJ,van Zeeland AA,Natarajan AT

更新日期：1986-06-01 00:00:00

abstract：:Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases....

journal_title：Carcinogenesis

authors： Tebbi A,Levillayer F,Jouvion G,Fiette L,Soubigou G,Varet H,Boudjadja N,Cairo S,Hashimoto K,Suzuki AM,Carninci P,Carissimo A,di Bernardo D,Wei Y

更新日期：2016-01-01 00:00:00

abstract：:4-Hydroxyphenylretinamide (4-HPR) is a synthetic retinoid with minimal toxicity and favorable pharmacokinetics during long-term administration to patients in clinical trials. Since 4-HPR binds poorly to the retinoic acid receptors, the issue of whether 4-HPR exerts its biological actions via classical retinoid recepto...

journal_title：Carcinogenesis

authors： Giandomenico V,Andreola F,Rodriguez de la Concepcion ML,Collins SJ,De Luca LM

更新日期：1999-06-01 00:00:00

abstract：:Treatment of human skin fibroblasts in early S-phase with (+-)7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE-I) results in more extensive modification of early replicating DNA than parental DNA. We have investigated the effects of benzamide (BZ) and 3-aminobenzamide (3-ABZ), i...

journal_title：Carcinogenesis

authors： Kurian P,Kumari HL,Milo GE

更新日期：1992-03-01 00:00:00

abstract：:Previous studies have shown that 1- and 3-nitrobenzo[a]pyrene (NBaP) were mutagenic in the Salmonella reversion assay without exogenous activation and that 1-, 3- and 6-NBaP were mutagenic in the presence of hepatocytes or liver homogenate (S9). In the present study, 1-, 3- and 6-NBaP were tested for mutagenicity in C...

journal_title：Carcinogenesis

authors： Hass BS,Heflich RH,Schol HM,Chou MW,Fu PP,Casciano DA

更新日期：1986-04-01 00:00:00

abstract：:We investigated possible mechanisms associated with promotion of hepatocarcinogenesis by the synthetic estrogens mestranol (M) and ethinyl estradiol (EE). Our first objective was to determine whether chronic EE treatment was associated with hepatotoxicity accompanied by regenerative hyperplasia. Female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Yager JD,Roebuck BD,Paluszcyk TL,Memoli VA

更新日期：1986-12-01 00:00:00

abstract：:CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be...

journal_title：Carcinogenesis

authors： Cheng M,Yang L,Yang R,Yang X,Deng J,Yu B,Huang D,Zhang S,Wang H,Qiu F,Zhou Y,Lu J

更新日期：2013-10-01 00:00:00

abstract：:Two solid-phase extraction methods were developed for the determination of mutagenic heterocyclic aromatic amines in heated meat products. The copper phthalocyanine (CPC) tandem extraction was performed on coupled cartridges of diatomaceous earth and CPC-derivatized Sephasorb HP, followed by further clean-up on Sephas...

journal_title：Carcinogenesis

authors： Gross GA

更新日期：1990-09-01 00:00:00

abstract：:Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...

journal_title：Carcinogenesis

authors： Smith CA,Xu YZ,Swann PF

更新日期：1990-05-01 00:00:00