The role of the Peyer's patch in carcinogenesis. II. 3-Methylcholanthrene-induced lymphoid malignancies in rat Peyer's patches.

abstract：:2-methoxyestradiol (2-MeOE(2)) is an endogenous metabolite of 17beta-estradiol and a proposed inhibitor of tumor growth and angiogenesis. However, 2-MeOE(2) is also an inhibitor of microtubule assembly and other microtubule inhibitors, e.g. colcemid and diethylstilbestrol, induce aneuploidy and cell transformation in ...

journal_title：Carcinogenesis

authors： Tsutsui T,Tamura Y,Hagiwara M,Miyachi T,Hikiba H,Kubo C,Barrett JC

更新日期：2000-04-01 00:00:00

abstract：:DL-N-acetyl-N'-nitrosotryptophan (I) and its methyl ester (II), readily formed under mild conditions by the reaction of nitrite with N-acetyltryptophan or its methyl ester, are model compounds for the study of the nitrosation of alpha-amino acid side chains, considered relevant to possible role of nitrosation of pepti...

journal_title：Carcinogenesis

authors： Venitt S,Crofton-Sleigh C,Ooi SL,Bonnett R

更新日期：1980-06-01 00:00:00

abstract：:A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] ...

journal_title：Carcinogenesis

authors： Kim HS,Kacew S,Lee BM

更新日期：1999-08-01 00:00:00

abstract：:The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...

journal_title：Carcinogenesis

authors： Lin M,Stewart DJ,Spitz MR,Hildebrandt MA,Lu C,Lin J,Gu J,Huang M,Lippman SM,Wu X

更新日期：2011-07-01 00:00:00

abstract：:Targeting tumor-initiating, drug-resistant populations of cancer stem cells (CSC) with phytochemicals is a novel paradigm for cancer prevention and treatment. We herein employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of ext...

journal_title：Carcinogenesis

authors： Corominas-Faja B,Cuyàs E,Lozano-Sánchez J,Cufí S,Verdura S,Fernández-Arroyo S,Borrás-Linares I,Martin-Castillo B,Martin ÁG,Lupu R,Nonell-Canals A,Sanchez-Martinez M,Micol V,Joven J,Segura-Carretero A,Menendez JA

更新日期：2018-04-05 00:00:00

abstract：:Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...

journal_title：Carcinogenesis

authors： Hacker HJ,Steinberg P,Bannasch P

更新日期：1998-01-01 00:00:00

abstract：:Thymidine kinase (TK), the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 15 specimens of normal mucosa, 14 polyps and 14 carcinomas in human colon. The average TK activities in colon polyps and carcinomas were about 1.6 and 2.9 times that in normal colon mucosa, respectively. The colon TK...

journal_title：Carcinogenesis

authors： Sakamoto S,Sagara T,Iwama T,Kawasaki T,Okamoto R

更新日期：1985-06-01 00:00:00

abstract：:The PEA3/E1AF/ETV4 gene encodes an Ets-related transcription factor that is expressed in the epithelial cells of the mammary gland. Previous reports have shown that PEA3 can up-regulate promoter activities of many genes associated with tumorigenesis. A significant fraction of those encode matrix metalloproteinases (MM...

journal_title：Carcinogenesis

authors： Bièche I,Tozlu S,Girault I,Onody P,Driouch K,Vidaud M,Lidereau R

更新日期：2004-03-01 00:00:00

abstract：:On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwen...

journal_title：Carcinogenesis

authors： Girardi B,Principi M,Pricci M,Giorgio F,Iannone A,Losurdo G,Ierardi E,Di Leo A,Barone M

更新日期：2018-10-08 00:00:00

abstract：:Teflon tubing used in the isolated, ventilated and perfused lung apparatus (IVPL) was found to yield artifactually high values for nitrosamine formation after it had been exposed to nitrite. In contrast to an earlier report, we found that submilligram levels of nitrite do not react to form significant quantities of ni...

journal_title：Carcinogenesis

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-05-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.0...

journal_title：Carcinogenesis

authors： Narisawa T,Fukaura Y,Terada K,Umezawa A,Tanida N,Yazawa K,Ishikawa C

更新日期：1994-09-01 00:00:00

abstract：:E mu-pim-1 transgenic mice, which overexpress the pim-1 oncogene in lymphoid tissues, have shown increased susceptibility to induction of T cell lymphomas by N-ethyl-N-nitrosourea, a direct-acting chemical carcinogen (Nature, 340, 61-63, 1989). We sought to further evaluate E mu-pim-1 transgenic mice as a potential te...

journal_title：Carcinogenesis

authors： Storer RD,Cartwright ME,Cook WO,Soper KA,Nichols WW

更新日期：1995-02-01 00:00:00

abstract：:To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. His...

journal_title：Carcinogenesis

authors： Mitsumori K,Onodera H,Shimo T,Yasuhara K,Takagi H,Koujitani T,Hirose M,Maruyama C,Wakana S

更新日期：2000-05-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had...

journal_title：Carcinogenesis

authors： Williams GM,Numoto S

更新日期：1984-12-01 00:00:00

abstract：:4,4'-Methylene-bis(2-chloroaniline) (MOCA) can produce tumors in rodents and dogs and an increased incidence of bladder tumors has been reported in exposed workers. It is therefore of interest to identify the human cytochrome P450 (P450) enzymes involved in MOCA N-oxidation, the primary reaction involved in the format...

journal_title：Carcinogenesis

authors： Yun CH,Shimada T,Guengerich FP

更新日期：1992-02-01 00:00:00

abstract：:The dose and time dependence of the cellular phenotype in preneoplastic and neoplastic liver lesions was evaluated quantitatively in groups of male Sprague-Dawley rats exposed for 7 weeks to 0, 12 and 24 mg/kg body wt of N-nitrosomorpholine (NNM) and studied at different time points up to 80 weeks after withdrawal of ...

journal_title：Carcinogenesis

authors： Weber E,Bannasch P

更新日期：1994-06-01 00:00:00

abstract：:The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis of the frequency of sister chromatid exchanges (SCEs) induced by DEB in whol...

journal_title：Carcinogenesis

authors： Norppa H,Hirvonen A,Järventaus H,Uusküla M,Tasa G,Ojajärvi A,Sorsa M

更新日期：1995-06-01 00:00:00

abstract：:Research on radiation carcinogenesis during the past 2 decades has focused on cellular and molecular mechanisms for the effects of radiation in mammalian cells. This paper will review several of these areas of research, as they may relate specifically to the induction of cancer by ionizing radiation. Knowledge of the ...

journal_title：Carcinogenesis

authors： Little JB

更新日期：2000-03-01 00:00:00

abstract：:Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the amino group of 5'-amino-5'-deoxythymidine have been kinetically studied in a PBS. The pseudo-first-order rate constant...

journal_title：Carcinogenesis

authors： Yano K

更新日期：1992-04-01 00:00:00

abstract：:A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...

journal_title：Carcinogenesis

authors： Brenner AV,Butler MA,Wang SS,Ruder AM,Rothman N,Schulte PA,Chanock SJ,Fine HA,Linet MS,Inskip PD

更新日期：2007-12-01 00:00:00

abstract：:The relationship between urinary metabolites and DNA damage in the urinary bladder epithelium of male and female rats was tested by alkaline elution assay after an intravesical injection of OPP or its urinary metabolites. 2-Phenyl-1,4-benzoquinone (PBQ) revealed a weak DNA-damaging activity in both sexes at 0.05-0.1%....

journal_title：Carcinogenesis

authors： Morimoto K,Sato M,Fukuoka M,Hasegawa R,Takahashi T,Tsuchiya T,Tanaka A,Takahashi A,Hayashi Y

更新日期：1989-10-01 00:00:00

abstract：:Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...

journal_title：Carcinogenesis

authors： Loprinzi CL,Verma AK

更新日期：1985-11-01 00:00:00

abstract：:The P53 tumor suppressor pathway plays an important role in cancer development. The auto-regulatory feedback mechanism of the P53 and MDM2 expression is critical in keeping proper tumor suppressor function of this pathway. This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 p...

journal_title：Carcinogenesis

authors： Yang M,Guo Y,Zhang X,Miao X,Tan W,Sun T,Zhao D,Yu D,Liu J,Lin D

更新日期：2007-09-01 00:00:00

abstract：:The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...

journal_title：Carcinogenesis

authors： Zeng T,Mitch WA

更新日期：2016-06-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:Tobacco-specific nitrosamines are a group of carcinogens that are present in tobacco and tobacco smoke. They are formed from nicotine and related tobacco alkaloids. Two of the nicotine-derived nitrosamines, NNK and NNN, are strong carcinogens in laboratory animals. They can induce tumors both locally and systemically....

journal_title：Carcinogenesis

authors： Hecht SS,Hoffmann D

更新日期：1988-06-01 00:00:00

abstract：:This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total o...

journal_title：Carcinogenesis

authors： Ide F,Iida N,Nakatsuru Y,Oda H,Tanaka K,Ishikawa T

更新日期：2000-06-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00