Abstract:
:This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA-/-, XPA(+/-) and XPA(+/+) mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total of 68 surviving XPA mice treated with B[a]P were examined at month 16. The pulmonary adenoma incidence in XPA(-/-) mice was significantly higher than that in XPA(+/+) mice (71 versus 35%). Similarly, tumor multiplicity was elevated and, in addition, only XPA(-/-) mice had lung carcinomas. These results provide the first evidence that a deficiency in the NER gene XPA leads to enhanced tumorigenesis in the lung after exposure to B[a]P.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Ide F,Iida N,Nakatsuru Y,Oda H,Tanaka K,Ishikawa Tkeywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
1263-5issue
6eissn
0143-3334issn
1460-2180journal_volume
21pub_type
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