Abstract:
:The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly among white males, over the past few decades in the USA. However, the etiology of EA and the striking male predominance is not fully explained by known risk factors. To identify susceptible genes for EA risk, we conducted a pathway-based candidate gene association study on 335 Caucasian EA cases and 319 Caucasian controls. A total of 1330 single-nucleotide polymorphisms (SNPs) selected from 354 genes were analyzed using an Illumina GoldenGate assay. The genotyped common SNPs include missense and exonic SNPs, SNPs within untranslated regions and 2 kb 5' of the gene, and tagSNPs for genes with little functional information available. Logistic regression adjusted for potential confounders was used to assess the genetic effect of each SNP on EA risk. We also tested gene-gender interactions using the likelihood ratio tests. We found that the genetic variants in the apoptosis pathway were significantly associated with EA risk after correcting for multiple comparisons. SNPs of rs3127075 in Caspase-7 (CASP7) and rs4661636 in Caspase-9 (CASP9) genes that play a critical role in apoptosis were found to be associated with an increased risk of EA. A protective effect of SNP rs572483 in the progesterone receptor (PGR) gene was observed among women carrying the variant G allele [adjusted odds ratio (OR) = 0.19; 95% confidence interval (CI) = 0.08-0.46] but was not observed among men (adjusted OR = 1.38; 95% CI = 0.95-2.00). In conclusion, this study suggests that the genetic variants of CASP7 and CASP9 in the apoptosis pathway may be important predictive markers for EA susceptibility and that PGR in the sex hormone signaling pathway may be associated with the gender differences in EA risk.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DCdoi
10.1093/carcin/bgq092subject
Has Abstractpub_date
2010-07-01 00:00:00pages
1259-63issue
7eissn
0143-3334issn
1460-2180pii
bgq092journal_volume
31pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::O6-Methylguanine-DNA methyltransferase (O6-MT) has been described as a DNA repair enzyme that reverses alkylation damage at the O6 position of guanine in DNA. We demonstrate that the concentration of this protein decreases immediately prior to DNA synthesis in cultured chick hepatocytes. If intracellular levels are ex...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.1.33
更新日期:1992-01-01 00:00:00
abstract::We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.7.1285
更新日期:1992-07-01 00:00:00
abstract::Occupational exposure to hydrocarbon solvents has been found to be associated with an increased risk of exocrine pancreatic cancer (EPC), the human tumor with the highest prevalence of K-ras mutations. Ras genes are critical DNA targets for chemical carcinogens. We analysed the relationship between past occupational e...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.1.101
更新日期:2002-01-01 00:00:00
abstract::The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding derivatives through the formation of an N-hydroxy intermediate. In this study, the subsequent activation of N-hydroxy-DMABP through acid catalysis or enzymatic esterification was examined. [Rin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.2.251
更新日期:1985-02-01 00:00:00
abstract::The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.11.889
更新日期:1980-01-01 00:00:00
abstract::Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of colon cancer. Curcumin, a dietary phytochemical, shows promising effects in suppressing colitis-associated colon cancer in azoxymethane-dextran sulfate sodium (AOM-DSS) m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy043
更新日期:2018-05-03 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi013
更新日期:2005-04-01 00:00:00
abstract::Previous epidemiological and laboratory studies have indicated an association between the ingestion of opium pyrolysates, dietary deficiencies and the high incidence of oesophageal cancer in subjects in north-east Iran. Pyrolysates of opium, and particularly of morphine, a major opium alkaloid, were both shown to cont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1423
更新日期:1987-10-01 00:00:00
abstract::An increased neuroendocrine (NE) cell population in prostate cancer is associated with more aggressive disease and recurrence after androgen-deprivation therapy, although the mechanism responsible is unknown. In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs139
更新日期:2012-06-01 00:00:00
abstract::A 25mer oligonucleotide containing a single N-(deoxyguanosin-8-yl-)-1-aminopyrene (dGAP), the major DNA adduct formed by reductively activated 1-nitropyrene, was synthesized. The adduct was located at nucleotide 21 from the 3' end. DNA synthesis on this template by human DNA polymerases alpha and beta, HIV reverse tra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.4.811
更新日期:1995-04-01 00:00:00
abstract::Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi019
更新日期:2005-04-01 00:00:00
abstract::Reflux of gastroduodenal contents and consequent inflammatory responses are associated with the development of Barrett's oesophagus (BO) and the promotion of oesophageal adenocarcinoma (OAC). Deregulation of inflammatory processes is a hallmark of oesophageal cancer. In this study, we aimed to investigate (i) the tran...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq036
更新日期:2010-05-01 00:00:00
abstract::Azido-IQ (2-azido-3-methylimidazo[4,5-f]quinoline), a novel analog of the food mutagen and carcinogen IQ (2-amino-3-methylimidazo[4,5-f]quinoline) was synthesized and characterized. Both thermolysis and photolysis of this azide yield a short-lived nitrene which can react as an electrophile either directly or via proto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.5.869
更新日期:1988-05-01 00:00:00
abstract::The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J. et al., 1998, Carcinogenesis, 19, 925-931). The peroxisome prolifera...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.9.1521
更新日期:1998-09-01 00:00:00
abstract::The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria. Omeprazole-treated rats gavaged with nitrosation-proficient bacteria were treated with nitrosamines and/or precursors and comp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.3.435
更新日期:1991-03-01 00:00:00
abstract::Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa050
更新日期:2020-10-15 00:00:00
abstract::Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down-regulation is a hallmark of malignant transformation. In the present report, we showed that the miR-128-3p, which is up-regulated in lung cancer tissues, has Drosha and Dicer, two key enzymes of mi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgx134
更新日期:2018-02-09 00:00:00
abstract::Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were gen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn258
更新日期:2009-01-01 00:00:00
abstract::We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high level...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn252
更新日期:2009-01-01 00:00:00
abstract::Occupational exposure to styrene was studied in nine workers of a hand lamination plant in Bohemia. Personal dosimeters were used to monitor the styrene workplace exposure, and the levels of styrene in blood and mandelic acid in urine were measured. Blood samples were taken at four occasions during a 7 month period to...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.7.1473
更新日期:1995-07-01 00:00:00
abstract::1,3-Butadiene (BD), a widely used monomer in the production of synthetic rubber and other resins, is one of the 189 hazardous air pollutants identified in the 1990 Clean Air Act Amendments. BD induces tumors at multiple organ sites in B6C3F1 mice and Sprague-Dawley rats; mice are much more susceptible to the carcinoge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.7.1143
更新日期:1992-07-01 00:00:00
abstract::Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr283
更新日期:2012-02-01 00:00:00
abstract::A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.317
更新日期:1991-02-01 00:00:00
abstract::The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.8.1403
更新日期:1992-08-01 00:00:00
abstract::Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various peroxisome proliferators on neoplasia as well as on selected biochemical parameters was studied. After treatment with diethylnitrosamine (DEN), the animals were subsequently subjected to a ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1899
更新日期:1990-11-01 00:00:00
abstract::Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.2.209
更新日期:1995-02-01 00:00:00
abstract::Consumption of fruits and vegetables has been associated with a decrease in cancer incidence and cardiovascular disease, presumably caused by antioxidants. We designed a human intervention study to assess antioxidative and possible anti-genotoxic properties of fruit-borne antioxidants. We hypothesized that individuals...
journal_title:Carcinogenesis
pub_type: 杂志文章,随机对照试验
doi:10.1093/carcin/bgm145
更新日期:2007-08-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz123
更新日期:2020-06-17 00:00:00
abstract::Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi081
更新日期:2005-08-01 00:00:00
abstract::The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg014
更新日期:2003-04-01 00:00:00