DNA polymerase action on an oligonucleotide containing a site-specifically located N-(deoxyguanosin-8-yl)-1-aminopyrene.

abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

journal_title：Carcinogenesis

authors： Stadtländer CT,Waterbor JW

更新日期：1999-12-01 00:00:00

abstract：:A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...

journal_title：Carcinogenesis

authors： Wirthner R,Wrann S,Balamurugan K,Wenger RH,Stiehl DP

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:This commentary was written to stimulate thoughts on, and consideration of, enzyme expression data in target organs when investigating possible associations between polymorphisms in carcinogen activation enzymes, lifestyle/dietary factors and cancer risk. The lung and breast are taken as examples. There is overwhelmin...

journal_title：Carcinogenesis

authors： Williams JA

更新日期：2001-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and the aryl hy...

journal_title：Carcinogenesis

authors： Smerdová L,Šmerdová J,Kabátková M,Kohoutek J,Blažek D,Machala M,Vondráček J

更新日期：2014-11-01 00:00:00

abstract：:Recent genome-wide association studies have identified 15 single nucleotide polymorphisms (SNPs) associated with non-Hodgkin lymphoma (NHL) and its subtypes. Because the incidence and subtype portion of NHL between the Chinese population and Caucasian populations are substantially different, we assessed the associatio...

journal_title：Carcinogenesis

authors： Qiao Y,Zhou Y,Wu C,Zhai K,Han X,Chen J,Tian X,Chang J,Lu Z,Zhang B,Yu D,Yao J,Shi Y,Tan W,Lin D

更新日期：2013-07-01 00:00:00

abstract：:To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...

journal_title：Carcinogenesis

authors： Beuten J,Gelfond JA,Piwkham D,Pollock BH,Winick NJ,Collier AB 3rd,Tomlinson GE

更新日期：2011-09-01 00:00:00

abstract：:Woodchuck (Marmota monax) hepatic cells, which were immortalized by the simian virus 40 large T antigen (SV40 Tag) produced nitric oxide (NO; measured as nitrite) in vitro from L-arginine (L-Arg) after lipopolysaccharide (LPS) treatment. NO synthesis was related to L-Arg and LPS concentration and plateaued at 1.0 mM L...

journal_title：Carcinogenesis

authors： Liu RH,Jacob JR,Hotchkiss JH,Tennant BC

更新日期：1993-08-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:Plant chlorophylls and carotenoids are highly colored, conjugated polyenes that play central roles in photosynthesis. Other porphyrins (tetrapyrroles), such as cytochromes, which are structurally related to chlorophyll, participate in redox reactions in many living systems. An unexpected new property of tetrapyrroles,...

journal_title：Carcinogenesis

authors： Fahey JW,Stephenson KK,Dinkova-Kostova AT,Egner PA,Kensler TW,Talalay P

更新日期：2005-07-01 00:00:00

abstract：:Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...

journal_title：Carcinogenesis

authors： Cho YY,Lee MH,Lee CJ,Yao K,Lee HS,Bode AM,Dong Z

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS:Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfec...

journal_title：Carcinogenesis

authors： Liu X,Wang L,Zhang S,Lin J,Zhang S,Feitelson MA,Gao H,Zhu M

更新日期：2008-06-01 00:00:00

abstract：:In this case-control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In individual single nucleotide polymorphis...

journal_title：Carcinogenesis

authors： Pan J,Lin J,Izzo JG,Liu Y,Xing J,Huang M,Ajani JA,Wu X

更新日期：2009-05-01 00:00:00

abstract：:Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...

journal_title：Carcinogenesis

authors： Yang H,Fang J,Jia X,Han C,Chen X,Yang CS,Li N

更新日期：2011-03-01 00:00:00

abstract：:Both trans-4-acetylaminostilbene (AAS) and 2-acetylaminofluorene (AAF) exert tumor-initiating activity in rat liver when administered in the initiation phase of an initiation-promotion experiment. The effects are more than additive when the compounds are sequentially combined in the initiation phase of such an experim...

journal_title：Carcinogenesis

authors： Ruthsatz M,Neumann HG

更新日期：1988-02-01 00:00:00

abstract：:The effect of transplantation of Yoshida sarcoma cells into rats on the concentrations of both the acute-phase proteins (APPs) in the serum and their mRNAs in the liver has been investigated. In rats that responded to transplantation by forming solid tumors, the serum APP levels increased with tumor size. Some of the ...

journal_title：Carcinogenesis

authors： Sevaljević L,Savovski K,Sekularac S

更新日期：1991-09-01 00:00:00

abstract：:Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...

journal_title：Carcinogenesis

authors： Ling MT,Kwok WK,Fung MK,Xianghong W,Wong YC

更新日期：2006-02-01 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...

journal_title：Carcinogenesis

authors： Flaks A,Flaks B

更新日期：1983-01-01 00:00:00

abstract：:Radioactive methylnitrosourea, epichlorohydrin, styrene oxide, and N-acetoxy-2-acetylaminofluorene were reacted with 14 different polyamino acids in vitro, to determine the relative reactivity of the functional groups in amino acids. All the carcinogens reacted preferentially with polycysteine and much less with polyh...

journal_title：Carcinogenesis

authors： Hemminki K

更新日期：1983-01-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to produce two transcripts, and the splicing pattern may be modulated by a G to A single nucleotide polymorphism within the sp...

journal_title：Carcinogenesis

authors： Wang L,Habuchi T,Takahashi T,Mitsumori K,Kamoto T,Kakehi Y,Kakinuma H,Sato K,Nakamura A,Ogawa O,Kato T

更新日期：2002-02-01 00:00:00

abstract：:The modifying effects of oltipraz on induction of glandular stomach carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in a total of 120 male 6-week-old Wistar rats, divided into six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in their drinking water for 10 weeks as an ...

journal_title：Carcinogenesis

authors： Nishikawa A,Tanakamura Z,Furukawa F,Lee IS,Kasahara K,Ikezaki S,Takahashi M

更新日期：1998-02-01 00:00:00

abstract：:Several purified polychlorinated biphenyl (PCB) congeners with differing toxicity/tumor promotional activities in rat liver in vivo were tested for their effects on gap-junctional intercellular communication (GJIC) in cell strains and lines derived from human liver and skin. This in vitro assay is being developed to d...

journal_title：Carcinogenesis

authors： Swierenga SH,Yamasaki H,Piccoli C,Robertson L,Bourgon L,Marceau N,Fitzgerald DJ

更新日期：1990-06-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining ...

journal_title：Carcinogenesis

authors： Zhu J,Zhang S,Gu L,Di W

更新日期：2012-12-01 00:00:00

abstract：:Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...

journal_title：Carcinogenesis

authors： Wild L,Funes JM,Boshoff C,Flanagan JM

更新日期：2010-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number of diseases, including cancer. Most ROS are created in the cell through normal cellular metabolism. They can be produced by environmental insults such as ultraviolet light and toxic chemicals, as well as by the inflammatory proc...

journal_title：Carcinogenesis

authors： Stoner GD,Wang LS,Casto BC

更新日期：2008-09-01 00:00:00

abstract：:In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...

journal_title：Carcinogenesis

authors： Del Carratore R,Morichetti E,Cecchini E,Bronzetti G,Gallo E,Galeotti CL

更新日期：1992-11-01 00:00:00