Abstract:
:The effect of transplantation of Yoshida sarcoma cells into rats on the concentrations of both the acute-phase proteins (APPs) in the serum and their mRNAs in the liver has been investigated. In rats that responded to transplantation by forming solid tumors, the serum APP levels increased with tumor size. Some of the APP was found to be infiltrated in the area of the tumor cells. Concentrations of the APP mRNAs in the liver were enhanced to an extent comparable to that observed for the encoded proteins, indicating that hepatocytes were the major site of their synthesis. In rats in which no formation of solid tumors occurred, the serum APP concentrations expressed a tendency to decrease below the control values. An inverse relationship between the rates of APP synthesis and the capability of rats to prevent proliferation of transplanted ascites tumor cells in the solid tumor form was discussed.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Sevaljević L,Savovski K,Sekularac Sdoi
10.1093/carcin/12.9.1601subject
Has Abstractpub_date
1991-09-01 00:00:00pages
1601-6issue
9eissn
0143-3334issn
1460-2180journal_volume
12pub_type
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