Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.

abstract：:An important issue in current oncological research is prevention as well as early detection of cancer. This includes also the difficulty to predict the progression of early or pre-cancerous lesions to invasive cancer. In this context, the characterization and categorization of pre-neoplastic lesions of squamous cell c...

journal_title：Carcinogenesis

authors： Wittenborn J,Weikert L,Hangarter B,Stickeler E,Maurer J

更新日期：2020-12-31 00:00:00

abstract：:Reactive intermediates (ultimate mutagens/carcinogens) generated by alkylating agents are unstable and difficult to characterize by chemical means. We have used a genetic system to distinguish the in vivo interactions of eight carcinogenic methylating agents and five ethylating agents by the patterns of induced mutati...

journal_title：Carcinogenesis

authors： Elespuru RK,Stupar LL,Gordon JA

更新日期：1991-07-01 00:00:00

abstract：:Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...

journal_title：Carcinogenesis

authors： Basten GP,Bao Y,Williamson G

更新日期：2002-08-01 00:00:00

abstract：:The role of rat O6-alkylguanine-DNA alkyltransferase (AGT) in modulating mutagenesis by O6-substituted guanines in the rat H-ras gene was examined. Rat4 cells were transfected with vectors carrying O6-methyl-, O6-ethyl- or O6-benzylguanine residues in place of the normal guanines at either the first, second, or both t...

journal_title：Carcinogenesis

authors： Bishop RE,Dunn LL,Pauly GT,Dolan ME,Moschel RC

更新日期：1993-04-01 00:00:00

abstract：:Exogenous chemical carcinogenesis is an extremely complex multifactorial process during which gene-environment interactions involving chronic exposure to exogenous chemical carcinogens (ECCs) and polymorphisms of cancer susceptibility genes add further complexity. We describe the properties and molecular mechanisms of...

journal_title：Carcinogenesis

authors： Irigaray P,Belpomme D

更新日期：2010-02-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:Epidemiologic studies have suggested that aromatic amines (and nitroaromatic hydrocarbons) may be carcinogenic for human pancreas. Pancreatic tissues from 29 organ donors (13 smokers, 16 non-smokers) were examined for their ability to metabolize aromatic amines and other carcinogens. Microsomes showed no activity for ...

journal_title：Carcinogenesis

authors： Anderson KE,Hammons GJ,Kadlubar FF,Potter JD,Kaderlik KR,Ilett KF,Minchin RF,Teitel CH,Chou HC,Martin MV,Guengerich FP,Barone GW,Lang NP,Peterson LA

更新日期：1997-05-01 00:00:00

abstract：:Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficientl...

journal_title：Carcinogenesis

authors： Sasaki R,Narisawa-Saito M,Yugawa T,Fujita M,Tashiro H,Katabuchi H,Kiyono T

更新日期：2009-03-01 00:00:00

abstract：:Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...

journal_title：Carcinogenesis

authors： Popova NV,Teti KA,Wu KQ,Morris RJ

更新日期：2003-03-01 00:00:00

abstract：:Prostate cancer (PCa) is the second cause of cancer deaths in men in the USA. When the cancer recurs, early stages can be controlled with hormone ablation therapy to delay the rate of cancer progression but, over time, the cancer overcomes its hormone dependence, becomes highly aggressive and metastasizes. Clinical tr...

journal_title：Carcinogenesis

authors： Wang L,Li W,Lin M,Garcia M,Mulholland D,Lilly M,Martins-Green M

更新日期：2014-10-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas. To further clarify the effect of MGMT gene expression on cellular chemosensitivity to 1-(4-amino-2-methyl-5-pyrimidinyl)-3-(2-chloroethyl)-3-nitrosou...

journal_title：Carcinogenesis

authors： Yang J,Chen JM,Zhang YP

更新日期：1995-09-01 00:00:00

abstract：:Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present wo...

journal_title：Carcinogenesis

authors： Banerjee S,Panda CK,Das S

更新日期：2006-08-01 00:00:00

abstract：:This report shows that generation of hydrogen peroxide (H2O2) by human polymorphonuclear leukocytes (PMNs) activated with tumor promoters of varying potency as first and second stage promoters correlates well with activities of these promoters in vivo. Those tested were 12-O-tetradecanoylphorbol-13-acetate (TPA), a co...

journal_title：Carcinogenesis

authors： Frenkel K,Chrzan K

更新日期：1987-03-01 00:00:00

abstract：:Catechol (1,2-dihydroxybenzene) is a major phenolic compound present in the co-carcinogenic fraction of cigarette tar. It has been shown to be a potent co-carcinogen with benzo[a]pyrene (BaP) in mouse skin. In this study we have examined the co-carcinogenic and co-initiating activities of catechol with racemic and ena...

journal_title：Carcinogenesis

authors： Melikian AA,Jordan KG,Braley J,Rigotty J,Meschter CL,Hecht SS,Hoffmann D

更新日期：1989-10-01 00:00:00

abstract：:Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...

journal_title：Carcinogenesis

authors： Baird WM,Zennie TM,Ferin M,Chae YH,Hatchell J,Cassady JM

更新日期：1988-04-01 00:00:00

abstract：:Mevastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis. Butyrate, a short-chain fatty acid, reduces proliferation and induces differentiation of human colon cancer cells. The aim of our study was to determine the effect of mevastatin, ...

journal_title：Carcinogenesis

authors： Wächtershäuser A,Akoglu B,Stein J

更新日期：2001-07-01 00:00:00

abstract：:Inactivation of the adenomatous polyposis coli (Apc) gene by loss of the wild-type Apc allele (LOH) is a prerequisite for the development of intestinal adenomas in Msh2 proficient Min (Apc+/-Msh2+/+) mice. In contrast, adenomas from Msh2 deficient Min (Apc+/-Msh2-/-) mice are not usually associated with LOH. Given the...

journal_title：Carcinogenesis

authors： Sohn KJ,Choi M,Song J,Chan S,Medline A,Gallinger S,Kim YI

更新日期：2003-02-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:We employed cDNA microarray analysis to identify, in mammary adenocarcinomas induced by 7,12-dimethylbenz[a] anthracene (DMBA) in the rat, target genes as potential biomarkers for cancer chemoprevention by 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Confirmation of selected genes was conducted by reverse transcr...

journal_title：Carcinogenesis

authors： El-Bayoumy K,Narayanan BA,Desai DH,Narayanan NK,Pittman B,Amin SG,Schwartz J,Nixon DW

更新日期：2003-09-01 00:00:00

abstract：:Non-classical class Ib (class Ib) genes are found in all jawed vertebrates, including the amphibian Xenopus, which possesses at least 20 distinct Xenopus non-classical class Ib genes (XNCs). As an immune evasion strategy, tumors often downregulate surface expression of classical major histocompatibility complex class ...

journal_title：Carcinogenesis

authors： Haynes-Gilmore N,Banach M,Edholm ES,Lord E,Robert J

更新日期：2014-08-01 00:00:00

abstract：:Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. We have used human hepatoma HepG2 cells to examine the regulation of TrxRs by isothiocyanate ...

journal_title：Carcinogenesis

authors： Zhang J,Svehlíková V,Bao Y,Howie AF,Beckett GJ,Williamson G

更新日期：2003-03-01 00:00:00

abstract：:Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...

journal_title：Carcinogenesis

authors： Bye H,Prescott NJ,Matejcic M,Rose E,Lewis CM,Parker MI,Mathew CG

更新日期：2011-12-01 00:00:00

abstract：:The expression of proteinase-activated receptor (PAR)(2) in human hepatocellular carcinoma (HCC) was established by reverse transcription-polymerase chain reaction, confocal immunofluorescence and electron microscopy in permanent cell lines, primary HCC cell cultures and HCC tumor tissue. Stimulation of HCC cells with...

journal_title：Carcinogenesis

authors： Kaufmann R,Oettel C,Horn A,Halbhuber KJ,Eitner A,Krieg R,Katenkamp K,Henklein P,Westermann M,Böhmer FD,Ramachandran R,Saifeddine M,Hollenberg MD,Settmacher U

更新日期：2009-09-01 00:00:00

abstract：:We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of messenger RNA (mRNA) stability, as observed for tumor growth factors (TGFs). Our ...

journal_title：Carcinogenesis

authors： Danilin S,Sourbier C,Thomas L,Rothhut S,Lindner V,Helwig JJ,Jacqmin D,Lang H,Massfelder T

更新日期：2009-03-01 00:00:00

abstract：:When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...

journal_title：Carcinogenesis

authors： Guo X,Ruiz A,Rando RR,Bok D,Gudas LJ

更新日期：2000-11-01 00:00:00

abstract：:Malondialdehyde (MDA), a product of lipid peroxidation, causes mutations in bacterial and mammalian cells and cancer in rats. MDA reacts with deoxynucleosides in vitro and the monomeric adduct of MDA with deoxyguanosine (M1G-dR) is the major adduct. M1G-dR has been detected in rat and human liver. Random mutagenesis s...

journal_title：Carcinogenesis

authors： Chaudhary AK,Reddy GR,Blair IA,Marnett LJ

更新日期：1996-05-01 00:00:00

abstract：:Mutations of the tumor suppressor gene p53 have been found in hepatocellular carcinomas (HCCs) from many countries where HCC is common, but p53 mutations detected by direct sequencing in HCCs from the United States (where HCC is uncommon) have been reported only rarely. p53 Exons 1 to 11 were analyzed by polymerase ch...

journal_title：Carcinogenesis

authors： Kazachkov Y,Khaoustov V,Yoffe B,Solomon H,Klintmalm GB,Tabor E

更新日期：1996-10-01 00:00:00

abstract：:Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...

journal_title：Carcinogenesis

authors： Goodall CM,Lijinsky W

更新日期：1984-04-01 00:00:00

abstract：:In order to develop more efficient in vitro systems for the study of pro-mutagenic or pro-carcinogenic chemicals, we have produced transgenic C3H/10T1/2 cell lines expressing human cytochrome P450 (CYP) 2A6. A retroviral vector containing the cDNA was packaged in psi-2 cells, and used to infect C3H/10T1/2 cells. From ...

journal_title：Carcinogenesis

authors： Tiano HF,Hosokawa M,Chulada PC,Smith PB,Wang RL,Gonzalez FJ,Crespi CL,Langenbach R

更新日期：1993-07-01 00:00:00